Abstract
Regulatory factors governing the formation of bone in the glenoid fossa in response to functional appliance therapy have not been identified. Therefore, the purpose of this study was to investigate the temporal pattern of expression of two key chondrogenesis markers-SOX9 and its target gene, type II collagen-in the glenoid fossa by immunostaining in a 35-day-old Sprague Dawley rat model during both natural growth and forward mandibular positioning. The expression of both factors was up-regulated when the mandible was positioned forward, indicating an enhancement of chondrocyte differentiation and chondroid matrix formation. Our results indicate that chondroid bone formation in the glenoid fossa in response to forward mandibular positioning is regulated by molecular markers indicative of endochondral ossification.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Cell Differentiation / drug effects
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Chondrocytes / drug effects
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Chondrogenesis / drug effects
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Collagen Type II / analysis*
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Collagen Type II / genetics
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Extracellular Matrix / drug effects
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Female
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High Mobility Group Proteins / analysis*
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High Mobility Group Proteins / genetics
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Mandible / anatomy & histology*
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Mandible / growth & development
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Models, Animal
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Orthodontic Appliances, Functional*
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Osteogenesis / drug effects
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Random Allocation
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Rats
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Rats, Sprague-Dawley
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SOX9 Transcription Factor
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Temporal Bone / growth & development
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Temporal Bone / metabolism*
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Transcription Factors / analysis*
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Transcription Factors / genetics
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Up-Regulation* / genetics
Substances
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Collagen Type II
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High Mobility Group Proteins
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SOX9 Transcription Factor
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Transcription Factors