Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chi-Ming Che; Raymond Wai-Yin Sun; Wing-Yiu Yu; Chi-Bun Ko; Nianyong Zhu; Hongzhe Sun

doi:10.1039/b303294a

Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chem Commun (Camb). 2003 Jul 21:(14):1718-9. doi: 10.1039/b303294a.

Authors

Chi-Ming Che¹, Raymond Wai-Yin Sun, Wing-Yiu Yu, Chi-Bun Ko, Nianyong Zhu, Hongzhe Sun

Affiliation

¹ Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong. cmche@hku.hk

PMID: 12877519
DOI: 10.1039/b303294a

Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / toxicity*
Apoptosis / drug effects*
Apoptosis / physiology
DNA / chemistry*
Female
Gold Compounds / chemistry
Gold Compounds / toxicity*
Humans
Porphyrins / chemistry
Porphyrins / toxicity*
Protein Binding / drug effects
Protein Binding / physiology
Tumor Cells, Cultured
Uterine Cervical Neoplasms / drug therapy
Uterine Cervical Neoplasms / metabolism

Substances

Antineoplastic Agents
Gold Compounds
Porphyrins
DNA