Abstract
The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimony / chemistry*
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Antiparasitic Agents / chemistry*
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Glutathione / analogs & derivatives*
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Glutathione / chemistry*
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Hydrogen-Ion Concentration
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Oxidation-Reduction
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Spermidine / analogs & derivatives*
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Spermidine / chemistry*
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Structure-Activity Relationship
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Temperature
Substances
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Antiparasitic Agents
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trypanothione
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Antimony
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Glutathione
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Spermidine