Abstract
We showed heterogeneous disease spectrum among 15 acute lymphoblastic leukemia (ALL) cases with mature B-cell phenotype diagnosed over the past 7 years at our institution. Besides those with typical L3 morphology and 8q24 (c-myc) translocation (n=6), there were cases showing L1 or L2 morphology without 8q24 translocation (n=6), unusually large L3 blasts in hyperdiploid clone (n=2) and blastoid variant of mantle cell lymphoma (n=1). The expression of CD5 and cyclin D1 may need to be routinely determined on ALL cases with mature B-cell phenotype and non-L3 morphology to facilitate timely diagnosis of blastoid MCL and institution of suitable management.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Bone Marrow Examination
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Burkitt Lymphoma / classification
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Burkitt Lymphoma / genetics
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Burkitt Lymphoma / pathology*
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CD5 Antigens / analysis
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Child
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Child, Preschool
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Chromosomes, Human, Pair 14
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Chromosomes, Human, Pair 8
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Cyclin D1 / analysis
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Cytogenetic Analysis
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Female
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Humans
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Immunophenotyping
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Lymphoma, Mantle-Cell / diagnosis
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Lymphoma, Mantle-Cell / pathology
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Male
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Middle Aged
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Phenotype
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / classification*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
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Retrospective Studies
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Translocation, Genetic