Inhibition of sulpiride on the cephalic phase of gastric acid and gastrin secretion in duodenal ulcer patients

Scand J Gastroenterol. 1976;11(1):27-31.

Abstract

In 13 patients with duodenal ulceration psychic stimulation with food resulted in a significant rise in gastric acid secretion and in serum gastrin. This rise was abolished when the patients were pre-treated with sulpiride, a non-sedative neuroleptic acting on the hypothalamus. These findings suggest that sulpiride, by virtue of its inhibitory effect on the cephalic phase of acid secretion, may be a useful adjunct in the treatment of duodenal ulcers.

MeSH terms

  • Adolescent
  • Adult
  • Depression, Chemical
  • Duodenal Ulcer / drug therapy*
  • Food
  • Gastric Juice / metabolism*
  • Gastrins / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Stress, Psychological
  • Sulpiride / metabolism*
  • Time Factors

Substances

  • Gastrins
  • Sulpiride