Lymphoepithelioma-like carcinoma of the parotid gland in a patient with rheumatoid arthritis

M Y Mok; W H Shek; R W S Wong

Lymphoepithelioma-like carcinoma of the parotid gland in a patient with rheumatoid arthritis

Clin Exp Rheumatol. 2002 Nov-Dec;20(6):848-50.

Authors

M Y Mok¹, W H Shek, R W S Wong

Affiliation

¹ Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.

PMID: 12508780

Abstract

Lymphoepithelioma-like carcinoma (LELC) is an Epstein-Barr virus (EBV) related malignancy. It is not a common condition and is usually found in the head and neck region. We describe the development of LELC involving the parotid gland in a patient with rheumatoid arthritis (RA) who had been receiving long-term azathioprine. A brief review is also made on the clinical presentation and histological features of LELC and the association of RA with EBV related diseases. The latter may be attributed to an increase in risk of malignancy associated with RA or as a result of the long-term immunosuppressive used.

Publication types

Case Reports

MeSH terms

Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / complications*
Arthritis, Rheumatoid / drug therapy
Arthritis, Rheumatoid / pathology
Azathioprine / therapeutic use
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / virology*
Epstein-Barr Virus Infections / complications*
Epstein-Barr Virus Infections / pathology
Female
Herpesvirus 4, Human* / genetics
Herpesvirus 4, Human* / isolation & purification
Humans
Immunocompromised Host
In Situ Hybridization
Middle Aged
Parotid Neoplasms / pathology
Parotid Neoplasms / virology*
RNA-Binding Proteins / analysis
Ribosomal Proteins*

Substances

Antirheumatic Agents
RNA-Binding Proteins
Ribosomal Proteins
RPL22 protein, human
Azathioprine