Hydrophobic interaction and hydrogen bonding cooperatively confer a vancomycin hydrogel: a potential candidate for biomaterials

J Am Chem Soc. 2002 Dec 18;124(50):14846-7. doi: 10.1021/ja028539f.

Abstract

Antibiotic hydrogels based on a vancomycin (Van) derivative, formed by self-assembling Van-pyrene (1) in water, using the pi-pi interaction of pyrene moieties and hydrogen bonding of Vans, promise a new way to make novel biomaterials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Calorimetry, Differential Scanning
  • Circular Dichroism
  • Hydrogels / chemistry*
  • Hydrogen Bonding
  • Microscopy, Electron
  • Molecular Conformation
  • Pyrenes / chemistry*
  • Spectrometry, Fluorescence
  • Vancomycin / analogs & derivatives
  • Vancomycin / chemistry*
  • Water / chemistry
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Hydrogels
  • Pyrenes
  • Water
  • Vancomycin
  • pyrene