Abstract
Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC(50) = 23.4 +/- 1.5 microM). Compounds 2 and 4 showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.42 and 32.3 +/- 2.62 micro, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biphenyl Compounds
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Cell Line / drug effects
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Chemical and Drug Induced Liver Injury / prevention & control*
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Coumarins / administration & dosage
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Coumarins / pharmacology
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Coumarins / therapeutic use
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Flavonoids / administration & dosage
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Flavonoids / pharmacology
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Flavonoids / therapeutic use
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / pharmacology*
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Free Radical Scavengers / therapeutic use
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Humans
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Inhibitory Concentration 50
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Morus*
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Phytotherapy*
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Picrates
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Structures
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Stilbenes / administration & dosage
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Stilbenes / pharmacology
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Stilbenes / therapeutic use
Substances
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Biphenyl Compounds
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Coumarins
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Flavonoids
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Free Radical Scavengers
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Picrates
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Plant Extracts
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Stilbenes
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coumarin
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1,1-diphenyl-2-picrylhydrazyl