Rapamycin blocks the generation of regulatory T cells facilitated by posttransplant infusion of donor T cells through increasing the apoptosis of thymic CD4(+)CD25(+) cells

Transplant Proc. 2002 Aug;34(5):1390-1. doi: 10.1016/s0041-1345(02)03067-1.

Authors

Tung-Yu Tsui¹, C-K Lau, H J Schlitt, S-T Fan

Affiliation

¹ Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road 102, Hong Kong, China.

PMID: 12176409
DOI: 10.1016/s0041-1345(02)03067-1

No abstract available

MeSH terms

Animals
Apoptosis / drug effects
Apoptosis / physiology*
CD4 Antigens / immunology*
Immunosuppression Therapy / methods
Lymphocyte Transfusion*
Male
Rats
Rats, Inbred Lew
Receptors, Interleukin-2 / immunology*
Sirolimus / pharmacology*
T-Lymphocytes / classification
T-Lymphocytes / drug effects
T-Lymphocytes / immunology*
Thymus Gland / immunology

Substances

CD4 Antigens
Receptors, Interleukin-2
Sirolimus