Abstract
Lung function abnormalities that are associated with thalassemia major are variable with etiology that is yet undetermined. Some studies have suggested that pulmonary iron deposition is a probable cause for these lung defects although there has been no antemortem histopathological and radiological evidence for this. We report a case of thalassemia major with biopsy-proven pulmonary iron overload, in which thoracic high-resolution computed tomography revealed a morphological-functional correlation consistent with small airway disease.
Copyright 2002 S. Karger AG, Basel
MeSH terms
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Adult
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Airway Obstruction / etiology*
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Biopsy
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Chelation Therapy
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Combined Modality Therapy
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Deferoxamine / therapeutic use
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Diabetes Mellitus, Type 1 / complications
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Female
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Hemosiderin / analysis
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Humans
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Hypothyroidism / complications
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Insulin / therapeutic use
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Iron Chelating Agents / therapeutic use
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Iron Overload / diagnosis*
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Iron Overload / diagnostic imaging
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Iron Overload / etiology
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Kidney Diseases / complications
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Lung Diseases / diagnosis*
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Lung Diseases / diagnostic imaging
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Lung Diseases / etiology
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Lung Diseases / pathology
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Macrophages / chemistry
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Macrophages / pathology
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Patient Compliance
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Splenectomy
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Tomography, X-Ray Computed
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Transfusion Reaction
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beta-Thalassemia / complications*
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beta-Thalassemia / surgery
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beta-Thalassemia / therapy
Substances
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Insulin
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Iron Chelating Agents
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Hemosiderin
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Deferoxamine