Chromosomal abnormalities in T-cell large granular lymphocyte leukaemia: report of two cases and review of the literature

Br J Haematol. 2002 Mar;116(3):598-600. doi: 10.1046/j.0007-1048.2001.03315.x.

Abstract

Cytogenetic information on T-cell large granular lymphocyte leukaemia (T-LGL; large granular lymphocytosis) is limited. We report two cases of T-LGL with unusual karyotypic aberrations. The first case showed a novel inv(7)(p15q22) as the sole chromosomal abnormality, while the second case showed an inv(14)(q11q32) with evidence of clonal evolution. The breakpoints 7p14-p15 and 14q11 coincide with the T-cell receptor (TCR)-gamma and TCR-alpha/TCR-delta gene loci respectively. This is the first report describing the possible involvement of T-cell receptor genes in karyotypic aberrations in T-LGL.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 14 / genetics
  • Chromosomes, Human, Pair 7 / genetics
  • Female
  • Humans
  • Karyotyping
  • Leukemia, T-Cell / genetics*
  • Middle Aged
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • Receptors, Antigen, T-Cell, gamma-delta / genetics

Substances

  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta