Differences in clinical and laboratory diagnostic characteristics of penicilliosis marneffei in human immunodeficiency virus (HIV)- and non-HIV-infected patients

J Clin Microbiol. 2001 Dec;39(12):4535-40. doi: 10.1128/JCM.39.12.4535-4540.2001.

Abstract

We compared the clinical and laboratory features of human immunodeficiency virus (HIV)- and non-HIV-infected patients with penicilliosis marneffei. HIV-infected patients had a higher incidence of fungemia. A total of 85.7% of the HIV-negative patients had underlying diseases including hematologic malignancies or had received therapy with corticosteroids or cytotoxic agents. By a Penicillium marneffei-specific mannoprotein Mp1p enzyme-linked immunosorbent assay, serum antigen titers were found to be higher in HIV-positive patients, whereas serum antibody levels were found to be higher in HIV-negative patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis*
  • AIDS-Related Opportunistic Infections / microbiology
  • AIDS-Related Opportunistic Infections / physiopathology*
  • Adolescent
  • Adult
  • Aged
  • Antibodies, Fungal / blood
  • Antigens, Fungal / analysis
  • Child
  • Culture Media
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fungemia / diagnosis
  • Fungemia / microbiology
  • Fungemia / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Mycoses / diagnosis*
  • Mycoses / microbiology
  • Mycoses / physiopathology*
  • Penicillium / growth & development
  • Penicillium / isolation & purification*

Substances

  • Antibodies, Fungal
  • Antigens, Fungal
  • Culture Media