Successful mismatched sibling cord blood transplant in Hb Bart's disease

Bone Marrow Transplant. 2001 Jul;28(1):105-7. doi: 10.1038/sj.bmt.1703104.

Abstract

A 20-month-old girl with Hb Bart's disease, who had survived neonatal complications, underwent HLA-DR antigen mismatched sibling cord blood transplantation successfully. Immune thrombocytopenia, which occurred around 2.5 months after transplant, responded to intravenous gamma-globulin. The fetal hemoglobin level rose to a peak of 52.3% on day +69 post transplant and declined gradually during the following year. Ten percent of hemoglobin Bart's was detected 2 months after transplant and this reflects the alpha-thalassemia trait of the donor.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Fetal Blood*
  • Graft Survival
  • HLA-DR Antigens
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods*
  • Hemoglobinopathies / blood
  • Hemoglobinopathies / complications
  • Hemoglobinopathies / therapy
  • Hemoglobins, Abnormal*
  • Histocompatibility / immunology*
  • Humans
  • Infant
  • Nuclear Family
  • Purpura, Thrombocytopenic, Idiopathic / drug therapy
  • Purpura, Thrombocytopenic, Idiopathic / etiology
  • Transplantation, Homologous / adverse effects
  • Transplantation, Homologous / immunology
  • Transplantation, Homologous / methods
  • alpha-Thalassemia / blood
  • alpha-Thalassemia / complications
  • alpha-Thalassemia / therapy

Substances

  • HLA-DR Antigens
  • Hemoglobins, Abnormal
  • hemoglobin Bart's