Tandem conjugate reduction-aldol cyclization using Stryker's reagent

Org Lett. 2001 Jun 14;3(12):1901-3. doi: 10.1021/ol015944n.

Abstract

[see reaction]. Conjugate reduction by Stryker's reagent to form copper enolates, followed by intramolecular aldol cyclization, successfully generated five- and six-membered carbocycles in one pot efficiently. This tandem reaction is generally diastereoselective and provides good yields of the beta-hydroxyketones without any dehydration at low temperatures.