Spontaneous rupture of hepatocellular carcinoma and vascular injury

Arch Surg. 2001 Jun;136(6):682-7. doi: 10.1001/archsurg.136.6.682.

Abstract

Hypothesis: Because spontaneous rupture of hepatocellular carcinoma (HCC) is one kind of bleeding complication related to the blood vessels, the possible mechanism of this rupture should occur on the blood vessel itself. Our hypothesis, which has not yet been investigated, is that the vascular integrity of HCC might be damaged during vascular injury.

Design: We examined semiquantitatively the expression of von Willebrand factor, elastin, neutrophil elastase, type IV collagen, and collagenase in 23 specimens of HCC with spontaneous rupture by immunohistochemistry, and compared them with 30 specimens of HCC without rupture.

Results: There was a significant decrease of von Willebrand factor, proliferation of degenerated elastin, abnormal distribution of neutrophil elastase, degradation of type IV collagen, and increase in collagenase production around the blood vessels in ruptured HCC. Since the decreased expression of von Willebrand factor is an indicator of vascular injury and elastase and collagenase are present in inflammatory processes, we postulate that the vascular injury probably exists before spontaneous rupture of HCC occurs. The blood vessel dysfunction resulting from the degeneration of elastin and the degradation of type IV collagen can render the blood vessels stiff and weak, causing them to split easily when the vascular load increases from hypertension or minor mechanical trauma.

Conclusion: Spontaneous rupture of HCC may be related to the vascular dysfunction.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Hepatocellular / blood
  • Carcinoma, Hepatocellular / etiology*
  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / surgery
  • Case-Control Studies
  • Collagen / analysis
  • Collagen / blood
  • Collagenases / analysis
  • Collagenases / blood
  • Elastin / analysis
  • Elastin / blood
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hepatectomy
  • Humans
  • Immunohistochemistry
  • Leukocyte Elastase / analysis
  • Leukocyte Elastase / blood
  • Liver / blood supply*
  • Liver Neoplasms / blood
  • Liver Neoplasms / etiology*
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / surgery
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Partial Thromboplastin Time
  • Prothrombin Time
  • Risk Factors
  • Rupture, Spontaneous
  • Vascular Diseases / complications*
  • von Willebrand Factor / analysis
  • von Willebrand Factor / metabolism

Substances

  • von Willebrand Factor
  • Collagen
  • Elastin
  • Leukocyte Elastase
  • Collagenases