Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs

Am J Hum Genet. 2001 Jun;68(6):1527-32. doi: 10.1086/320593. Epub 2001 May 14.

Abstract

The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the "revisited" method, which uses the cross-product--rather than the squared difference--in sib trait values, is, in general, less powerful than VC models. In this report, we clarify the relative efficiencies of existing Haseman-Elston methods and show how a new Haseman-Elston method can be constructed to have power equivalent to that of VC models. This method uses as the dependent variable a linear combination of squared sums and squared differences, in which the weights are determined by the overall trait correlation between sibs in a population. We show how this method can be used for both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of such selected samples.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chi-Square Distribution
  • Chromosome Mapping / methods*
  • Chromosome Mapping / statistics & numerical data*
  • Computer Simulation
  • Genetic Linkage / genetics*
  • Genotype
  • Humans
  • Matched-Pair Analysis
  • Nuclear Family
  • Quantitative Trait, Heritable
  • Regression Analysis