Reversible renal failure in paroxysmal nocturnal hemoglobinuria

Am J Kidney Dis. 2001 Feb;37(2):E17. doi: 10.1053/ajkd.2001.21361.

Abstract

A Chinese patient with paroxysmal nocturnal hemoglobinuria (PNH) developed acute nonoliguric renal failure with intercurrent urinary tract infection and hemolysis. There was no evidence of renal vein thrombosis. Renal biopsy showed features of acute tubular necrosis (ATN) and hemosiderosis. Magnetic resonance imaging (MRI) showed characteristic features of renal hemosiderosis. The patient was stabilized with temporary hemodialysis and intravenous fluid. The renal function fully recovered 3 weeks later. We review the literature and summarize the clinical features of this disease entity. To our knowledge, this case is the first to report such disorder with thorough investigation including concomitant diagnostic MRI imaging and renal biopsy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / etiology*
  • Creatinine / blood
  • Female
  • Hemoglobinuria, Paroxysmal / complications*
  • Hemoglobinuria, Paroxysmal / diagnosis
  • Humans
  • Kidney / pathology
  • Kidney Tubules / pathology
  • Kidney Tubules / ultrastructure
  • Magnetic Resonance Imaging
  • Middle Aged
  • Necrosis
  • Urinary Tract Infections / etiology

Substances

  • Creatinine