Lipids, lipophilic drugs, and oral drug delivery-some emerging concepts

J Pharm Sci. 2000 Aug;89(8):967-78. doi: 10.1002/1520-6017(200008)89:8<967::aid-jps1>3.0.co;2-r.

Abstract

Lipid-based dose forms, which encompass a wide variety of compositional and functional characteristics, can be advantageously utilized for the formulation of lipophilic drugs. There has been a traditional reluctance to develop lipid-based dose forms due to potential problems of chemical and physical instability, and a paucity of knowledge regarding formulation design algorithms and technology transfer issues. However, there is a current resurgence of interest in lipid-based dose forms due to potential commercial and pharmaceutical benefits, and the industry trend towards the discovery/development of increasingly hydrophobic (and potent) new chemical entities. This mini-review describes some emerging formulation and biopharmaceutic strategies that hold promise for better understanding how to design and evaluate lipid-based dose forms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Administration, Oral
  • Animals
  • Chemistry, Pharmaceutical*
  • Drug Delivery Systems*
  • Humans
  • Intestinal Mucosa / metabolism
  • Intestines / cytology
  • Lipids / administration & dosage*
  • Lipoproteins / blood
  • Lymphatic System / metabolism
  • Solubility

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Lipids
  • Lipoproteins