Chronic intracerebroventricular infusion of beta-amyloid (1-40) results in a selective loss of neuropeptides in addition to a reduction in choline acetyltransferase activity in the cortical mantle and hippocampus in the rat

Ann N Y Acad Sci. 1999:897:420-2. doi: 10.1111/j.1749-6632.1999.tb07911.x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / pharmacology*
  • Animals
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • Cerebral Ventricles / drug effects
  • Cerebral Ventricles / physiology*
  • Choline O-Acetyltransferase / metabolism*
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • Infusions, Parenteral
  • Male
  • Maze Learning / drug effects*
  • Neuropeptides / metabolism*
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Amyloid beta-Peptides
  • Neuropeptides
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • Choline O-Acetyltransferase