Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy

R G Parry; K M Gillespie; A G Clark; P W Mathieson

doi:10.1046/j.1365-2370.1999.00161.x

Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy

Eur J Immunogenet. 1999 Oct;26(5):321-3. doi: 10.1046/j.1365-2370.1999.00161.x.

Authors

R G Parry¹, K M Gillespie, A G Clark, P W Mathieson

Affiliation

¹ Academic Renal Unit, Southmead Hospital, Bristol, UK.

PMID: 10553496
DOI: 10.1046/j.1365-2370.1999.00161.x

Abstract

Dysregulation of Flt-1, a major receptor for vascular permeability factor (VPF), may provide a mechanism for the development of proteinuria in minimal change nephropathy (MCN). The gene for Flt-1 has a polymorphic dinucleotide repeat. We have demonstrated an 88% predominance of one allele and an 80% rate of homozygosity for this polymorphism with no association with MCN.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Black People / genetics
Dinucleotide Repeats*
Gene Frequency
Genetic Predisposition to Disease
Homozygote
Humans
Nephrosis, Lipoid / genetics*
Polymorphism, Genetic*
Proto-Oncogene Proteins / genetics*
Receptor Protein-Tyrosine Kinases / genetics*
Reference Values
Vascular Endothelial Growth Factor Receptor-1
White People / genetics

Substances

Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases
Vascular Endothelial Growth Factor Receptor-1