Translocation (12;17)(q13;q23) in de novo acute myeloid leukemia with trilineage myelodysplasia

Cancer Genet Cytogenet. 1999 Oct 15;114(2):159-61. doi: 10.1016/s0165-4608(99)00062-x.

Abstract

12q13 abnormalities have been reported to be associated with a variety of benign and malignant solid tumors. Recently, they have been shown to be a nonrandom karyotypic change in acute myeloid leukemia. We report a case of de novo acute myeloid leukemia with trilineage myelodysplasia showing t(12;17)(q13;q23) as the sole chromosomal abnormality. A review of the literature indicates that 12q13 translocation in acute myeloid leukemia is often associated with concomitant dysmyelopoietic changes. There is also evidence to suggest that 12q13 translocation occurs more frequently in acute myeloid leukemia with a prior history of mutagenic exposure or karyotypic indicators of secondary leukemia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Adult
  • Chromosomes, Human, Pair 12 / genetics*
  • Chromosomes, Human, Pair 17 / genetics*
  • Fatal Outcome
  • Humans
  • Karyotyping
  • Leukemia, Myeloid / genetics*
  • Leukemia, Myeloid / pathology
  • Male
  • Myelodysplastic Syndromes / genetics*
  • Myelodysplastic Syndromes / pathology
  • Translocation, Genetic / genetics*