The effect of streptozotocin-diabetes on beta-endorphin level and proopiomelanocortin gene expression in the rat pituitary

Neurosci Lett. 1999 Feb 12;261(1-2):118-20. doi: 10.1016/s0304-3940(98)01008-8.

Abstract

Streptozotocin-induced diabetes for 4 weeks resulted in a decrease in proopiomelanocortin (POMC) mRNA in both the anterior lobe (AL) and the neuro-intermediate lobe (NIL) of the rat pituitary. The beta-endorphin levels decreased in the NIL but not in the AL. It is concluded that the synthesis of POMC in the pituitary is inhibited in diabetic rats and that there is a decrease in beta-endorphin release from the anterior pituitary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose
  • Diabetes Mellitus, Experimental / genetics
  • Diabetes Mellitus, Experimental / metabolism*
  • Gene Expression / physiology
  • Hypoglycemic Agents / pharmacology
  • Insulin / pharmacology
  • Male
  • Pituitary Gland / chemistry
  • Pituitary Gland / physiology*
  • Pro-Opiomelanocortin / genetics*
  • RNA, Messenger / analysis
  • Rats
  • Rats, Sprague-Dawley
  • beta-Endorphin / metabolism*

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • RNA, Messenger
  • beta-Endorphin
  • Pro-Opiomelanocortin