Protein Family Models for Protein (Select 546160123) - Protein Family Models

Select item 3999501.

HAD hydrolase-like protein

Date:: 2023-12-12

Family Accession:: NF024639.4
Method:: HMM

Select item 3993472.

HAD hydrolase-like protein

Date:: 2023-12-12

Family Accession:: NF024811.4
Method:: HMM

Select item 3892223.

HAD family hydrolase

This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2]. [1]. 8702766. Crystal structure of L-2-haloacid dehalogenase from Pseudomonas. sp. YL. An alpha/beta hydrolase structure that is different from. the alpha/beta hydrolase fold.. Hisano T, Hata Y, Fujii T, Liu JQ, Kurihara T, Esaki N, Soda K;. J Biol Chem 1996;271:20322-20330.. [2]. 20485265. A mitochondrial phosphatase required for cardiolipin. biosynthesis: the PGP phosphatase Gep4.. Osman C, Haag M, Wieland FT, Brugger B, Langer T;. EMBO J. 2010;29:1976-1987 (from Pfam)

Date:: 2024-04-03

Family Accession:: NF012905.4
Method:: HMM

Select item 3587834.

new record, indexing in progress

Family Accession:

Select item 3577185.

new record, indexing in progress

Family Accession:

Select item 3469836.

new record, indexing in progress

Family Accession:

Select item 3327417.

new record, indexing in progress

Family Accession:

Select item 3253528.

new record, indexing in progress

Family Accession:

Select item 3159109.

new record, indexing in progress

Family Accession:

Select item 15971810.

new record, indexing in progress

Family Accession:

Select item 15899811.

new record, indexing in progress

Family Accession:

Select item 14159112.

HAD-IA family hydrolase

This HMM represents part of one structural subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The superfamily is defined by the presence of three short catalytic motifs [PMID:7966317]. The subfamilies are defined [PMID:11601995] based on the location and the observed or predicted fold of a so-called "capping domain" [PMID:10956028], or the absence of such a domain. Subfamily I consists of sequences in which the capping domain is found in between the first and second catalytic motifs. Subfamily II consists of sequences in which the capping domain is found between the second and third motifs. Subfamily III sequences have no capping domain in either of these positions.

GO Terms:

Biological Process:: metabolic process (GO:0008152)

Molecular Function:: hydrolase activity (GO:0016787)

Date:: 2021-04-27

Family Accession:: TIGR01549.1
Method:: HMM

Select item 5615213.

new record, indexing in progress

Family Accession:

Select item 5511514.

new record, indexing in progress

Family Accession:

Select item 4793415.

YjjG family noncanonical pyrimidine nucleotidase

This HAD superfamily includes including YjjG from E. coli and YfnB from B. subtilis. YjjG has been shown to act as a house-cleaning enzyme, cleaving nucleotides with non-canonical nucleotide bases. This family is a member of the haloacid dehalogenase (HAD) superfamily of hydrolases which are characterized by three conserved sequence motifs [2]. By virtue of an alpha helical domain in-between the first and second conserved motif, this family is a member of subfamily IA (TIGR01549).

GO Terms:

Molecular Function:: 5'-nucleotidase activity (GO:0008253)

Date:: 2024-02-27

Family Accession:: TIGR02254.1
Method:: HMM

Select item 2785916.

new record, indexing in progress

Family Accession:

Select item 2754017.

new record, indexing in progress

Family Accession:

Select item 1792618.

pyrimidine 5'-nucleotidase

Gene:: yjjG

GO Terms:

Molecular Function:: 5'-nucleotidase activity (GO:0008253)

Date:: 2021-09-22

Family Accession:: NF006976.0
Method:: HMM

Protein Family Models

Protein Family

Send to:

Links from Protein

Items: 18

Send to:

Supplemental Content

Find related data

Recent activity