Protein Family Models

This family contains several Chlamydia polymorphic membrane proteins. Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. This domain is found between the beta-helical repeats (Pfam:PF02415) and the C-terminal Pfam:PF03797. This domain is excised subsequent to secretion [2]. First identification of the domain. [1]. 15837807. The Chlamydophila abortus genome sequence reveals an array of. variable proteins that contribute to interspecies variation.. Thomson NR, Yeats C, Bell K, Holden MT, Bentley SD, Livingstone. M, Cerdeno-Tarraga AM, Harris B, Doggett J, Ormond D, Mungall K,. Clarke K, Feltwell T, Hance Z, Sanders M, Quail MA, Price C,. Barrell BG, Parkhill J, Longbottom D;. Genome Res 2005;15:629-640.. [2]. 14756775. From the inside out--processing of the Chlamydial. autotransporter PmpD and its role in bacterial adhesion and. activation of human host cells.. Wehrl W, Brinkmann V, Jungblut PR, Meyer TF, Szczepek AJ;. Mol Microbiol 2004;51:319-334. (from Pfam)

Date:

2024-04-03

This family contains several Chlamydia polymorphic membrane proteins. Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. Common for the Pmps are the tetrapeptide GGA(I/V/L) motif repeated several times in the N-terminal part. The C-terminal half is characterised by conserved tryptophans and a carboxy-terminal phenylalanine. A signal peptide leader sequence is predicted in 20 C. pneumoniae Pmps, which indicates an outer membrane localisation. Pmp10 and Pmp11 contain a signal peptidase II cleavage site suggesting lipid modification. The C. pneumoniae pmp genes represent 17.5% of the chlamydia-specific coding capacity and they are all transcribed during chlamydial growth but the function of Pmps remains unknown [1]. This family shows some similarity to Pfam:PF05594 and hence is likely to also form a beta-helical structure (personal obs:C Yeats). [1]. 11583841. Differential expression of Pmp10 in cell culture infected with. Chlamydia pneumoniae CWL029.. Pedersen AS, Christiansen G, Birkelund S;. FEMS Microbiol Lett 2001;203:153-159. (from Pfam)

Date:

2024-04-03

This HMM represents a repeat region of about 27 residues that appears from twice to over twenty times in Chlamydial polymorphic outer membrane proteins (POMP). Characteristic motifs in the repeat are FXXN and GGAI. Except for a few apparently truncated examples, Chlamydial proteins have this repeat region if and only if they also have the autotransporter beta-domain (PF03797) at the C-terminus, with Phe as the C-terminal residue. This repeat is observed, but is very rare, outside the Chlamydias.

Date:

2021-07-01

protein containing domains POMP_repeat, ChlamPMP_M, and Autotransporter

Date:

2017-03-02