Protein Family Models for Protein (Select 494447367) - Protein Family Models

Select item 3915261.

NAD(P)-binding domain-containing protein

The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold. (from Pfam)

GO Terms:

Molecular Function:: NADP binding (GO:0050661)

Date:: 2023-12-12

Family Accession:: NF015411.4
Method:: HMM

Select item 3891402.

6-phosphogluconate dehydrogenase, C-terminal domain

This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each. (from Pfam)

GO Terms:

Molecular Function:: phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616)

Biological Process:: pentose-phosphate shunt (GO:0006098)

Date:: 2023-12-12

Family Accession:: NF012611.4
Method:: HMM

Select item 3504273.

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Family Accession:

Select item 3469664.

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Family Accession:

Select item 3192225.

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Family Accession:

Select item 3156886.

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Family Accession:

Select item 1436507.

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Family Accession:

Select item 1423068.

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Family Accession:

Select item 1300069.

decarboxylating 6-phosphogluconate dehydrogenase

NADP-dependent decarboxylating 6-phosphogluconate dehydrogenase (6-PGDH) catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH

GO Terms:

Molecular Function:: phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616)

Molecular Function:: NADP binding (GO:0050661)

Date:: 2022-11-10

Family Accession:: 11484385
Method:: Sparcle

Select item 2415410.

phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)

This family resembles the larger family (gnd) of bacterial and eukaryotic NADP+-dependent 6-phosphogluconate dehydrogenase (EC 1.1.1.44), but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. It differs also in being NAD+-dependent, making this family EC 1.1.1.343. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle.

Gene:: gnd

GO Terms:

Biological Process:: pentose-phosphate shunt (GO:0006098)

Molecular Function:: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)

Date:: 2024-02-28

Family Accession:: TIGR00872.1
Method:: HMM

Select item 1911811.

NADP-dependent phosphogluconate dehydrogenase

Date:: 2021-03-12

Family Accession:: NF007161.0
Method:: HMM

Select item 1334412.

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Family Accession:

Select item 1303813.

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Family Accession:

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