Protein Family Models for Protein (Select 492538975) - Protein Family Models

Select item 3947241.

This HMM hits multiple proteins of peptidoglycan (murein) biosynthesis, such as MurC, MurD, MurE, and MurF of Escherichia coli.

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2023-12-12

Family Accession:: NF019850.4
Method:: HMM

Select item 3904302.

cyanophycin synthetase

This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate. [1]. 9218784. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate. ligase from Escherichia coli.. Bertrand JA, Auger G, Fanchon E, Martin L, Blanot D, van. Heijenoort J, Dideberg O;. EMBO J 1997;16:3416-3425. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: ligase activity (GO:0016874)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2024-04-03

Family Accession:: NF014874.4
Method:: HMM

Select item 3889313.

Mur ligase domain-containing protein

This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate. [1]. 9218784. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate. ligase from Escherichia coli.. Bertrand JA, Auger G, Fanchon E, Martin L, Blanot D, van. Heijenoort J, Dideberg O;. EMBO J 1997;16:3416-3425. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2024-04-03

Family Accession:: NF013396.4
Method:: HMM

Select item 3535784.

new record, indexing in progress

Family Accession:

Select item 3489555.

new record, indexing in progress

Family Accession:

Select item 3484916.

new record, indexing in progress

Family Accession:

Select item 3285617.

new record, indexing in progress

Family Accession:

Select item 3171298.

new record, indexing in progress

Family Accession:

Select item 3170839.

new record, indexing in progress

Family Accession:

Select item 14177710.

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ.

Gene:: murF

GO Terms:

Molecular Function:: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766)

Biological Process:: peptidoglycan biosynthetic process (GO:0009252)

Molecular Function:: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity (GO:0047480)

Date:: 2024-02-28

Family Accession:: TIGR01143.1
Method:: HMM

Select item 3547211.

new record, indexing in progress

Family Accession:

Select item 3495812.

new record, indexing in progress

Family Accession:

Select item 940313.

new record, indexing in progress

Family Accession:

Select item 899514.

new record, indexing in progress

Family Accession:

Select item 532215.

new record, indexing in progress

Family Accession:

Select item 471016.

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Family Accession:

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