Protein Family Models

The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel. [1]. 15111112. The plug domain of a neisserial TonB-dependent transporter. retains structural integrity in the absence of its transmembrane. beta-barrel.. Oke M, Sarra R, Ghirlando R, Farnaud S, Gorringe AR, Evans RW,. Buchanan SK;. FEBS Lett 2004;564:294-300. (from Pfam)

Date:

2024-04-03

This model now only covers the conserved part of the barrel structure. [1]. 9886293. Crystal structure of the outer membrane active transporter FepA. from Escherichia coli.. Buchanan SK, Smith BS, Venkatramani L, Xia D, Esser L, Palnitkar. M, Chakraborty R, van der Helm D, Deisenhofer J;. Nat Struct Biol 1999;6:56-63. (from Pfam)

Date:

2024-04-03