dbSNP Short Genetic Variations
Welcome to the Reference SNP (rs) Report
All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.
Reference SNP (rs) Report
This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.
rs1946518
Current Build 156
Released September 21, 2022
- Organism
- Homo sapiens
- Position
-
chr11:112164735 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
- Alleles
- T>G
- Variation Type
- SNV Single Nucleotide Variation
- Frequency
-
T=0.407159 (107771/264690, TOPMED)T=0.408969 (79129/193484, ALFA)T=0.405964 (56770/139840, GnomAD) (+ 20 more)
- Clinical Significance
- Not Reported in ClinVar
- Gene : Consequence
- IL18 : 2KB Upstream Variant
- Publications
- 145 citations
- Genomic View
- See rs on genome
ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.
Release Version: 20230706150541
| Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|
| Total | Global | 193484 | T=0.408969 | G=0.591031 |
| European | Sub | 166236 | T=0.409887 | G=0.590113 |
| African | Sub | 7088 | T=0.3648 | G=0.6352 |
| African Others | Sub | 264 | T=0.390 | G=0.610 |
| African American | Sub | 6824 | T=0.3639 | G=0.6361 |
| Asian | Sub | 736 | T=0.526 | G=0.474 |
| East Asian | Sub | 590 | T=0.515 | G=0.485 |
| Other Asian | Sub | 146 | T=0.568 | G=0.432 |
| Latin American 1 | Sub | 842 | T=0.404 | G=0.596 |
| Latin American 2 | Sub | 6852 | T=0.4742 | G=0.5258 |
| South Asian | Sub | 5048 | T=0.3243 | G=0.6757 |
| Other | Sub | 6682 | T=0.4178 | G=0.5822 |
Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").
Download| Study | Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|---|
| TopMed | Global | Study-wide | 264690 | T=0.407159 | G=0.592841 |
| Allele Frequency Aggregator | Total | Global | 193484 | T=0.408969 | G=0.591031 |
| Allele Frequency Aggregator | European | Sub | 166236 | T=0.409887 | G=0.590113 |
| Allele Frequency Aggregator | African | Sub | 7088 | T=0.3648 | G=0.6352 |
| Allele Frequency Aggregator | Latin American 2 | Sub | 6852 | T=0.4742 | G=0.5258 |
| Allele Frequency Aggregator | Other | Sub | 6682 | T=0.4178 | G=0.5822 |
| Allele Frequency Aggregator | South Asian | Sub | 5048 | T=0.3243 | G=0.6757 |
| Allele Frequency Aggregator | Latin American 1 | Sub | 842 | T=0.404 | G=0.596 |
| Allele Frequency Aggregator | Asian | Sub | 736 | T=0.526 | G=0.474 |
| gnomAD - Genomes | Global | Study-wide | 139840 | T=0.405964 | G=0.594036 |
| gnomAD - Genomes | European | Sub | 75770 | T=0.41217 | G=0.58783 |
| gnomAD - Genomes | African | Sub | 41872 | T=0.35893 | G=0.64107 |
| gnomAD - Genomes | American | Sub | 13620 | T=0.46270 | G=0.53730 |
| gnomAD - Genomes | Ashkenazi Jewish | Sub | 3320 | T=0.5127 | G=0.4873 |
| gnomAD - Genomes | East Asian | Sub | 3108 | T=0.5106 | G=0.4894 |
| gnomAD - Genomes | Other | Sub | 2150 | T=0.4279 | G=0.5721 |
| The PAGE Study | Global | Study-wide | 78698 | T=0.43173 | G=0.56827 |
| The PAGE Study | AfricanAmerican | Sub | 32516 | T=0.36477 | G=0.63523 |
| The PAGE Study | Mexican | Sub | 10806 | T=0.47455 | G=0.52545 |
| The PAGE Study | Asian | Sub | 8318 | T=0.5749 | G=0.4251 |
| The PAGE Study | PuertoRican | Sub | 7918 | T=0.4400 | G=0.5600 |
| The PAGE Study | NativeHawaiian | Sub | 4534 | T=0.4835 | G=0.5165 |
| The PAGE Study | Cuban | Sub | 4230 | T=0.4459 | G=0.5541 |
| The PAGE Study | Dominican | Sub | 3828 | T=0.4258 | G=0.5742 |
| The PAGE Study | CentralAmerican | Sub | 2450 | T=0.4869 | G=0.5131 |
| The PAGE Study | SouthAmerican | Sub | 1982 | T=0.5025 | G=0.4975 |
| The PAGE Study | NativeAmerican | Sub | 1260 | T=0.4365 | G=0.5635 |
| The PAGE Study | SouthAsian | Sub | 856 | T=0.320 | G=0.680 |
| 14KJPN | JAPANESE | Study-wide | 28258 | T=0.58058 | G=0.41942 |
| 8.3KJPN | JAPANESE | Study-wide | 16758 | T=0.58283 | G=0.41717 |
| 1000Genomes_30x | Global | Study-wide | 6404 | T=0.4096 | G=0.5904 |
| 1000Genomes_30x | African | Sub | 1786 | T=0.3628 | G=0.6372 |
| 1000Genomes_30x | Europe | Sub | 1266 | T=0.4218 | G=0.5782 |
| 1000Genomes_30x | South Asian | Sub | 1202 | T=0.2895 | G=0.7105 |
| 1000Genomes_30x | East Asian | Sub | 1170 | T=0.5282 | G=0.4718 |
| 1000Genomes_30x | American | Sub | 980 | T=0.485 | G=0.515 |
| 1000Genomes | Global | Study-wide | 5008 | T=0.4079 | G=0.5921 |
| 1000Genomes | African | Sub | 1322 | T=0.3502 | G=0.6498 |
| 1000Genomes | East Asian | Sub | 1008 | T=0.5268 | G=0.4732 |
| 1000Genomes | Europe | Sub | 1006 | T=0.4235 | G=0.5765 |
| 1000Genomes | South Asian | Sub | 978 | T=0.288 | G=0.712 |
| 1000Genomes | American | Sub | 694 | T=0.491 | G=0.509 |
| Genetic variation in the Estonian population | Estonian | Study-wide | 4480 | T=0.4170 | G=0.5830 |
| The Avon Longitudinal Study of Parents and Children | PARENT AND CHILD COHORT | Study-wide | 3854 | T=0.3952 | G=0.6048 |
| UK 10K study - Twins | TWIN COHORT | Study-wide | 3708 | T=0.3972 | G=0.6028 |
| KOREAN population from KRGDB | KOREAN | Study-wide | 2930 | T=0.5099 | G=0.4901 |
| HGDP-CEPH-db Supplement 1 | Global | Study-wide | 2084 | T=0.4213 | G=0.5787 |
| HGDP-CEPH-db Supplement 1 | Est_Asia | Sub | 470 | T=0.521 | G=0.479 |
| HGDP-CEPH-db Supplement 1 | Central_South_Asia | Sub | 414 | T=0.367 | G=0.633 |
| HGDP-CEPH-db Supplement 1 | Middle_Est | Sub | 350 | T=0.451 | G=0.549 |
| HGDP-CEPH-db Supplement 1 | Europe | Sub | 320 | T=0.400 | G=0.600 |
| HGDP-CEPH-db Supplement 1 | Africa | Sub | 242 | T=0.426 | G=0.574 |
| HGDP-CEPH-db Supplement 1 | America | Sub | 216 | T=0.412 | G=0.588 |
| HGDP-CEPH-db Supplement 1 | Oceania | Sub | 72 | T=0.04 | G=0.96 |
| HapMap | Global | Study-wide | 1874 | T=0.4130 | G=0.5870 |
| HapMap | American | Sub | 764 | T=0.397 | G=0.603 |
| HapMap | African | Sub | 686 | T=0.347 | G=0.653 |
| HapMap | Asian | Sub | 250 | T=0.592 | G=0.408 |
| HapMap | Europe | Sub | 174 | T=0.489 | G=0.511 |
| Korean Genome Project | KOREAN | Study-wide | 1832 | T=0.5158 | G=0.4842 |
| Genome of the Netherlands Release 5 | Genome of the Netherlands | Study-wide | 998 | T=0.410 | G=0.590 |
| CNV burdens in cranial meningiomas | Global | Study-wide | 784 | T=0.482 | G=0.518 |
| CNV burdens in cranial meningiomas | CRM | Sub | 784 | T=0.482 | G=0.518 |
| Northern Sweden | ACPOP | Study-wide | 600 | T=0.490 | G=0.510 |
| SGDP_PRJ | Global | Study-wide | 454 | T=0.289 | G=0.711 |
| Qatari | Global | Study-wide | 216 | T=0.426 | G=0.574 |
| Siberian | Global | Study-wide | 44 | T=0.30 | G=0.70 |
| The Danish reference pan genome | Danish | Study-wide | 40 | T=0.33 | G=0.68 |
| Ancient Sardinia genome-wide 1240k capture data generation and analysis | Global | Study-wide | 8 | T=0.0 | G=1.0 |
Help
Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.
Genomic Placements
| Sequence name | Change |
|---|---|
| GRCh38.p14 chr 11 | NC_000011.10:g.112164735T>G |
| GRCh37.p13 chr 11 | NC_000011.9:g.112035458T>G |
| IL18 RefSeqGene | NG_028143.1:g.4383A>C |
Gene: IL18, interleukin 18
(minus strand)
:
2KB Upstream Variant
| Molecule type | Change | Amino acid[Codon] | SO Term |
|---|---|---|---|
| IL18 transcript variant 2 | NM_001243211.2:c. | N/A | Upstream Transcript Variant |
| IL18 transcript variant 3 | NM_001386420.1:c. | N/A | Upstream Transcript Variant |
| IL18 transcript variant 1 | NM_001562.4:c. | N/A | Upstream Transcript Variant |
| IL18 transcript variant X1 | XM_011542805.2:c. | N/A | Upstream Transcript Variant |
Help
Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.
Not Reported in ClinVar
Help
Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".
| Placement | T= | G |
|---|---|---|
| GRCh38.p14 chr 11 | NC_000011.10:g.112164735= | NC_000011.10:g.112164735T>G |
| GRCh37.p13 chr 11 | NC_000011.9:g.112035458= | NC_000011.9:g.112035458T>G |
| IL18 RefSeqGene | NG_028143.1:g.4383= | NG_028143.1:g.4383A>C |
| TEX12 transcript variant X2 | XM_005271612.1:c.-24-4510= | XM_005271612.1:c.-24-4510T>G |
Help
Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.
151 SubSNP,
23 Frequency
submissions
| No | Submitter | Submission ID | Date (Build) |
|---|---|---|---|
| 1 | TSC-CSHL | ss2839965 | Jan 12, 2001 (92) |
| 2 | SC_JCM | ss4099301 | Nov 05, 2001 (101) |
| 3 | SC_JCM | ss6038070 | Feb 20, 2003 (111) |
| 4 | WI_SSAHASNP | ss6826157 | Feb 20, 2003 (111) |
| 5 | IIPGA-WEISS-MARTINEZ | ss7988381 | Apr 21, 2003 (114) |
| 6 | BCM_SSAHASNP | ss10704141 | Jul 11, 2003 (116) |
| 7 | WI_SSAHASNP | ss12173269 | Jul 11, 2003 (116) |
| 8 | SC_SNP | ss15623300 | Feb 27, 2004 (120) |
| 9 | CSHL-HAPMAP | ss19197155 | Feb 27, 2004 (120) |
| 10 | CSHL-HAPMAP | ss19906852 | Feb 27, 2004 (120) |
| 11 | SSAHASNP | ss20835262 | Apr 05, 2004 (121) |
| 12 | SEQUENOM | ss24785618 | Sep 20, 2004 (123) |
| 13 | KYUGEN | ss28461411 | Sep 20, 2004 (123) |
| 14 | KYUGEN | ss28461413 | Sep 20, 2004 (123) |
| 15 | ABI | ss38791303 | Mar 14, 2006 (126) |
| 16 | SHGC | ss66538707 | Nov 29, 2006 (127) |
| 17 | ILLUMINA | ss66610002 | Nov 29, 2006 (127) |
| 18 | ILLUMINA | ss67209373 | Nov 29, 2006 (127) |
| 19 | ILLUMINA | ss67602308 | Nov 29, 2006 (127) |
| 20 | RSG_JCVI | ss69359730 | May 16, 2007 (127) |
| 21 | RSG_JCVI | ss69361304 | May 16, 2007 (127) |
| 22 | ILLUMINA | ss70687629 | May 23, 2008 (130) |
| 23 | ILLUMINA | ss71252178 | May 16, 2007 (127) |
| 24 | ILLUMINA | ss75436702 | Dec 06, 2007 (129) |
| 25 | ILLUMINA | ss79103084 | Dec 14, 2007 (130) |
| 26 | KRIBB_YJKIM | ss83925496 | Dec 14, 2007 (130) |
| 27 | HGSV | ss85665754 | Dec 14, 2007 (130) |
| 28 | BCMHGSC_JDW | ss88794865 | Mar 24, 2008 (129) |
| 29 | BGI | ss103001219 | Dec 01, 2009 (131) |
| 30 | 1000GENOMES | ss111086297 | Jan 25, 2009 (130) |
| 31 | ILLUMINA-UK | ss119959418 | Dec 01, 2009 (131) |
| 32 | ILLUMINA | ss121861226 | Dec 01, 2009 (131) |
| 33 | ENSEMBL | ss132831895 | Dec 01, 2009 (131) |
| 34 | ENSEMBL | ss137855247 | Dec 01, 2009 (131) |
| 35 | ILLUMINA | ss153790031 | Dec 01, 2009 (131) |
| 36 | GMI | ss156797684 | Dec 01, 2009 (131) |
| 37 | ILLUMINA | ss159342712 | Dec 01, 2009 (131) |
| 38 | ILLUMINA | ss160479980 | Dec 01, 2009 (131) |
| 39 | COMPLETE_GENOMICS | ss168751449 | Jul 04, 2010 (132) |
| 40 | COMPLETE_GENOMICS | ss170895547 | Jul 04, 2010 (132) |
| 41 | ILLUMINA | ss170899652 | Jul 04, 2010 (132) |
| 42 | ILLUMINA | ss173004050 | Jul 04, 2010 (132) |
| 43 | COMPLETE_GENOMICS | ss175279647 | Jul 04, 2010 (132) |
| 44 | BUSHMAN | ss203216353 | Jul 04, 2010 (132) |
| 45 | BCM-HGSC-SUB | ss207890529 | Jul 04, 2010 (132) |
| 46 | 1000GENOMES | ss211197443 | Jul 14, 2010 (132) |
| 47 | 1000GENOMES | ss225464708 | Jul 14, 2010 (132) |
| 48 | 1000GENOMES | ss235721283 | Jul 15, 2010 (132) |
| 49 | 1000GENOMES | ss242318663 | Jul 15, 2010 (132) |
| 50 | ILLUMINA | ss244285817 | Jul 04, 2010 (132) |
| 51 | GMI | ss281173095 | May 04, 2012 (137) |
| 52 | GMI | ss286458614 | Apr 25, 2013 (138) |
| 53 | PJP | ss291140919 | May 09, 2011 (134) |
| 54 | ILLUMINA | ss480354703 | May 04, 2012 (137) |
| 55 | ILLUMINA | ss480366663 | May 04, 2012 (137) |
| 56 | ILLUMINA | ss481135325 | Sep 08, 2015 (146) |
| 57 | ILLUMINA | ss484974942 | May 04, 2012 (137) |
| 58 | ILLUMINA | ss537012847 | Sep 08, 2015 (146) |
| 59 | SSMP | ss658352337 | Apr 25, 2013 (138) |
| 60 | ILLUMINA | ss778473679 | Aug 21, 2014 (142) |
| 61 | ILLUMINA | ss782933768 | Aug 21, 2014 (142) |
| 62 | ILLUMINA | ss783896532 | Aug 21, 2014 (142) |
| 63 | ILLUMINA | ss825433602 | Jul 19, 2016 (147) |
| 64 | ILLUMINA | ss832189247 | Apr 01, 2015 (144) |
| 65 | ILLUMINA | ss832854680 | Aug 21, 2014 (142) |
| 66 | ILLUMINA | ss833445510 | Aug 21, 2014 (142) |
| 67 | ILLUMINA | ss833929486 | Aug 21, 2014 (142) |
| 68 | EVA-GONL | ss988968994 | Aug 21, 2014 (142) |
| 69 | JMKIDD_LAB | ss1078049706 | Aug 21, 2014 (142) |
| 70 | 1000GENOMES | ss1342988647 | Aug 21, 2014 (142) |
| 71 | DDI | ss1426762856 | Apr 01, 2015 (144) |
| 72 | EVA_GENOME_DK | ss1575956651 | Apr 01, 2015 (144) |
| 73 | EVA_DECODE | ss1598634315 | Apr 01, 2015 (144) |
| 74 | EVA_UK10K_ALSPAC | ss1627474399 | Apr 01, 2015 (144) |
| 75 | EVA_UK10K_TWINSUK | ss1670468432 | Apr 01, 2015 (144) |
| 76 | EVA_SVP | ss1713285081 | Apr 01, 2015 (144) |
| 77 | ILLUMINA | ss1751994577 | Sep 08, 2015 (146) |
| 78 | HAMMER_LAB | ss1806999663 | Sep 08, 2015 (146) |
| 79 | WEILL_CORNELL_DGM | ss1932330169 | Feb 12, 2016 (147) |
| 80 | ILLUMINA | ss1959385806 | Feb 12, 2016 (147) |
| 81 | GENOMED | ss1967460011 | Jul 19, 2016 (147) |
| 82 | JJLAB | ss2026909114 | Sep 14, 2016 (149) |
| 83 | ILLUMINA | ss2094791892 | Dec 20, 2016 (150) |
| 84 | ILLUMINA | ss2095026236 | Dec 20, 2016 (150) |
| 85 | USC_VALOUEV | ss2155221658 | Dec 20, 2016 (150) |
| 86 | HUMAN_LONGEVITY | ss2185755631 | Dec 20, 2016 (150) |
| 87 | SYSTEMSBIOZJU | ss2627929053 | Nov 08, 2017 (151) |
| 88 | ILLUMINA | ss2632887962 | Nov 08, 2017 (151) |
| 89 | ILLUMINA | ss2635030423 | Nov 08, 2017 (151) |
| 90 | GRF | ss2699530963 | Nov 08, 2017 (151) |
| 91 | GNOMAD | ss2904527195 | Nov 08, 2017 (151) |
| 92 | SWEGEN | ss3008789787 | Nov 08, 2017 (151) |
| 93 | ILLUMINA | ss3021376411 | Nov 08, 2017 (151) |
| 94 | BIOINF_KMB_FNS_UNIBA | ss3027255002 | Nov 08, 2017 (151) |
| 95 | CSHL | ss3349797649 | Nov 08, 2017 (151) |
| 96 | ILLUMINA | ss3626751069 | Oct 12, 2018 (152) |
| 97 | ILLUMINA | ss3630901922 | Oct 12, 2018 (152) |
| 98 | ILLUMINA | ss3632999530 | Oct 12, 2018 (152) |
| 99 | ILLUMINA | ss3633699491 | Oct 12, 2018 (152) |
| 100 | ILLUMINA | ss3634475510 | Oct 12, 2018 (152) |
| 101 | ILLUMINA | ss3635390775 | Oct 12, 2018 (152) |
| 102 | ILLUMINA | ss3636159824 | Oct 12, 2018 (152) |
| 103 | ILLUMINA | ss3637141677 | Oct 12, 2018 (152) |
| 104 | ILLUMINA | ss3637930705 | Oct 12, 2018 (152) |
| 105 | ILLUMINA | ss3638979038 | Oct 12, 2018 (152) |
| 106 | ILLUMINA | ss3639490768 | Oct 12, 2018 (152) |
| 107 | ILLUMINA | ss3640182846 | Oct 12, 2018 (152) |
| 108 | ILLUMINA | ss3642927156 | Oct 12, 2018 (152) |
| 109 | URBANLAB | ss3649706505 | Oct 12, 2018 (152) |
| 110 | ILLUMINA | ss3651743903 | Oct 12, 2018 (152) |
| 111 | EGCUT_WGS | ss3676116270 | Jul 13, 2019 (153) |
| 112 | EVA_DECODE | ss3692610354 | Jul 13, 2019 (153) |
| 113 | ILLUMINA | ss3725276703 | Jul 13, 2019 (153) |
| 114 | ACPOP | ss3738545264 | Jul 13, 2019 (153) |
| 115 | ILLUMINA | ss3744776286 | Jul 13, 2019 (153) |
| 116 | EVA | ss3749818262 | Jul 13, 2019 (153) |
| 117 | PAGE_CC | ss3771652786 | Jul 13, 2019 (153) |
| 118 | ILLUMINA | ss3772276051 | Jul 13, 2019 (153) |
| 119 | PACBIO | ss3787069230 | Jul 13, 2019 (153) |
| 120 | PACBIO | ss3792193141 | Jul 13, 2019 (153) |
| 121 | PACBIO | ss3797075661 | Jul 13, 2019 (153) |
| 122 | KHV_HUMAN_GENOMES | ss3815149688 | Jul 13, 2019 (153) |
| 123 | EVA | ss3832842049 | Apr 26, 2020 (154) |
| 124 | EVA | ss3839982932 | Apr 26, 2020 (154) |
| 125 | EVA | ss3845464615 | Apr 26, 2020 (154) |
| 126 | HGDP | ss3847431517 | Apr 26, 2020 (154) |
| 127 | SGDP_PRJ | ss3877149752 | Apr 26, 2020 (154) |
| 128 | KRGDB | ss3925606280 | Apr 26, 2020 (154) |
| 129 | KOGIC | ss3970758705 | Apr 26, 2020 (154) |
| 130 | EVA | ss3984657341 | Apr 26, 2021 (155) |
| 131 | EVA | ss3985557217 | Apr 26, 2021 (155) |
| 132 | EVA | ss4017559291 | Apr 26, 2021 (155) |
| 133 | TOPMED | ss4900189585 | Apr 26, 2021 (155) |
| 134 | TOMMO_GENOMICS | ss5203917693 | Apr 26, 2021 (155) |
| 135 | EVA | ss5237501190 | Apr 26, 2021 (155) |
| 136 | 1000G_HIGH_COVERAGE | ss5288923103 | Oct 16, 2022 (156) |
| 137 | EVA | ss5315577100 | Oct 16, 2022 (156) |
| 138 | HUGCELL_USP | ss5483909191 | Oct 16, 2022 (156) |
| 139 | 1000G_HIGH_COVERAGE | ss5585418741 | Oct 16, 2022 (156) |
| 140 | SANFORD_IMAGENETICS | ss5624285625 | Oct 16, 2022 (156) |
| 141 | SANFORD_IMAGENETICS | ss5652084815 | Oct 16, 2022 (156) |
| 142 | TOMMO_GENOMICS | ss5752373410 | Oct 16, 2022 (156) |
| 143 | EVA | ss5799854452 | Oct 16, 2022 (156) |
| 144 | YY_MCH | ss5812781901 | Oct 16, 2022 (156) |
| 145 | EVA | ss5837237180 | Oct 16, 2022 (156) |
| 146 | EVA | ss5847397857 | Oct 16, 2022 (156) |
| 147 | EVA | ss5847648165 | Oct 16, 2022 (156) |
| 148 | EVA | ss5850153350 | Oct 16, 2022 (156) |
| 149 | EVA | ss5921680329 | Oct 16, 2022 (156) |
| 150 | EVA | ss5943413298 | Oct 16, 2022 (156) |
| 151 | EVA | ss5979371853 | Oct 16, 2022 (156) |
| 152 | 1000Genomes | NC_000011.9 - 112035458 | Oct 12, 2018 (152) |
| 153 | 1000Genomes_30x | NC_000011.10 - 112164735 | Oct 16, 2022 (156) |
| 154 | The Avon Longitudinal Study of Parents and Children | NC_000011.9 - 112035458 | Oct 12, 2018 (152) |
| 155 | Genetic variation in the Estonian population | NC_000011.9 - 112035458 | Oct 12, 2018 (152) |
| 156 | The Danish reference pan genome | NC_000011.9 - 112035458 | Apr 26, 2020 (154) |
| 157 | gnomAD - Genomes | NC_000011.10 - 112164735 | Apr 26, 2021 (155) |
| 158 | Genome of the Netherlands Release 5 | NC_000011.9 - 112035458 | Apr 26, 2020 (154) |
| 159 | HGDP-CEPH-db Supplement 1 | NC_000011.8 - 111540668 | Apr 26, 2020 (154) |
| 160 | HapMap | NC_000011.10 - 112164735 | Apr 26, 2020 (154) |
| 161 | KOREAN population from KRGDB | NC_000011.9 - 112035458 | Apr 26, 2020 (154) |
| 162 | Korean Genome Project | NC_000011.10 - 112164735 | Apr 26, 2020 (154) |
| 163 | Northern Sweden | NC_000011.9 - 112035458 | Jul 13, 2019 (153) |
| 164 | The PAGE Study | NC_000011.10 - 112164735 | Jul 13, 2019 (153) |
| 165 | Ancient Sardinia genome-wide 1240k capture data generation and analysis | NC_000011.9 - 112035458 | Apr 26, 2021 (155) |
| 166 | CNV burdens in cranial meningiomas | NC_000011.9 - 112035458 | Apr 26, 2021 (155) |
| 167 | Qatari | NC_000011.9 - 112035458 | Apr 26, 2020 (154) |
| 168 | SGDP_PRJ | NC_000011.9 - 112035458 | Apr 26, 2020 (154) |
| 169 | Siberian | NC_000011.9 - 112035458 | Apr 26, 2020 (154) |
| 170 | 8.3KJPN | NC_000011.9 - 112035458 | Apr 26, 2021 (155) |
| 171 | 14KJPN | NC_000011.10 - 112164735 | Oct 16, 2022 (156) |
| 172 | TopMed | NC_000011.10 - 112164735 | Apr 26, 2021 (155) |
| 173 | UK 10K study - Twins | NC_000011.9 - 112035458 | Oct 12, 2018 (152) |
| 174 | ALFA | NC_000011.10 - 112164735 | Apr 26, 2021 (155) |
Help
History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).
| Associated ID | History Updated (Build) |
|---|---|
| rs57159524 | May 23, 2008 (130) |
Added to this RefSNP Cluster:
| Submission IDs | Observation SPDI | Canonical SPDI | Source RSIDs |
|---|---|---|---|
| 109409, ss85665754, ss88794865, ss111086297, ss119959418, ss160479980, ss168751449, ss170895547, ss175279647, ss203216353, ss207890529, ss211197443, ss244285817, ss281173095, ss286458614, ss291140919, ss480354703, ss825433602, ss1598634315, ss1713285081, ss2635030423, ss3638979038, ss3639490768, ss3642927156, ss3847431517 | NC_000011.8:111540667:T:G | NC_000011.10:112164734:T:G | (self) |
| 55571895, 30845039, 21854518, 2737921, 13765709, 32783674, 11830129, 783144, 206826, 14372099, 29166732, 7738012, 61887000, 30845039, ss225464708, ss235721283, ss242318663, ss480366663, ss481135325, ss484974942, ss537012847, ss658352337, ss778473679, ss782933768, ss783896532, ss832189247, ss832854680, ss833445510, ss833929486, ss988968994, ss1078049706, ss1342988647, ss1426762856, ss1575956651, ss1627474399, ss1670468432, ss1751994577, ss1806999663, ss1932330169, ss1959385806, ss1967460011, ss2026909114, ss2094791892, ss2095026236, ss2155221658, ss2627929053, ss2632887962, ss2699530963, ss2904527195, ss3008789787, ss3021376411, ss3349797649, ss3626751069, ss3630901922, ss3632999530, ss3633699491, ss3634475510, ss3635390775, ss3636159824, ss3637141677, ss3637930705, ss3640182846, ss3651743903, ss3676116270, ss3738545264, ss3744776286, ss3749818262, ss3772276051, ss3787069230, ss3792193141, ss3797075661, ss3832842049, ss3839982932, ss3877149752, ss3925606280, ss3984657341, ss3985557217, ss4017559291, ss5203917693, ss5237501190, ss5315577100, ss5624285625, ss5652084815, ss5799854452, ss5837237180, ss5847397857, ss5847648165, ss5943413298, ss5979371853 | NC_000011.9:112035457:T:G | NC_000011.10:112164734:T:G | (self) |
| 72944676, 392144820, 700170, 27136706, 874255, 86210514, 115735241, 10340675812, ss2185755631, ss3027255002, ss3649706505, ss3692610354, ss3725276703, ss3771652786, ss3815149688, ss3845464615, ss3970758705, ss4900189585, ss5288923103, ss5483909191, ss5585418741, ss5752373410, ss5812781901, ss5850153350, ss5921680329 | NC_000011.10:112164734:T:G | NC_000011.10:112164734:T:G | (self) |
| ss10704141, ss12173269 | NT_033899.5:15579124:T:G | NC_000011.10:112164734:T:G | (self) |
| ss15623300, ss19197155, ss19906852, ss20835262 | NT_033899.6:15579241:T:G | NC_000011.10:112164734:T:G | (self) |
| ss2839965, ss4099301, ss6038070, ss6826157, ss7988381, ss24785618, ss28461411, ss28461413, ss38791303, ss66538707, ss66610002, ss67209373, ss67602308, ss69359730, ss69361304, ss70687629, ss71252178, ss75436702, ss79103084, ss83925496, ss103001219, ss121861226, ss132831895, ss137855247, ss153790031, ss156797684, ss159342712, ss170899652, ss173004050 | NT_033899.8:15597873:T:G | NC_000011.10:112164734:T:G | (self) |
Help
Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.
145
citations for rs1946518
| PMID | Title | Author | Year | Journal |
|---|---|---|---|---|
| 15896202 | Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis. | Rueda B et al. | 2005 | Tissue antigens |
| 16078996 | Association study of functional genetic variants of innate immunity related genes in celiac disease. | Rueda B et al. | 2005 | BMC medical genetics |
| 16443795 | Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing. | Szeszko JS et al. | 2006 | Diabetes |
| 16542373 | Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults. | Song W et al. | 2006 | Clinical and experimental immunology |
| 16909454 | NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia. | Boraska V et al. | 2006 | Croatian medical journal |
| 17705862 | Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples. | Pullat J et al. | 2007 | BMC genomics |
| 17854431 | Interleukin-18 gene polymorphisms and haplotypes in patients with oral lichen planus: a study in an ethnic Chinese cohort. | Bai J et al. | 2007 | Tissue antigens |
| 17919265 | Polymorphism of interleukin-18 promoter influences the onset of kidney graft function after transplantation. | Kolesar L et al. | 2007 | Tissue antigens |
| 18043444 | Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. | Puthothu B et al. | 2007 | The Pediatric infectious disease journal |
| 18307517 | Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans. | Taudorf S et al. | 2008 | Clinical and experimental immunology |
| 18504197 | [Correlation of serum IL-18 level and IL-18 gene promoter polymorphisms to the risk of cervical cancer]. | Qi T et al. | 2008 | Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
| 19073159 | Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease. | Yu JT et al. | 2009 | Brain research |
| 19178691 | Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery. | Shaw DM et al. | 2009 | Critical care (London, England) |
| 19229765 | Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis. | Pawlik A et al. | 2009 | Scandinavian journal of rheumatology |
| 19455410 | Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response. | Haas SL et al. | 2009 | Journal of clinical immunology |
| 19961892 | Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients. | Sáenz-López P et al. | 2010 | Human immunology |
| 20097272 | Interleukin-18 promoter polymorphisms and risk of ischemic stroke. | Zhang N et al. | 2010 | Brain research bulletin |
| 20304021 | Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders. | Izakovicova Holla L et al. | 2010 | Human immunology |
| 20331879 | Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis. | Palomino-Morales RJ et al. | 2010 | Arthritis research & therapy |
| 20416077 | Identification of type 2 diabetes-associated combination of SNPs using support vector machine. | Ban HJ et al. | 2010 | BMC genetics |
| 20478055 | Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. | Brophy K et al. | 2010 | BMC medical genetics |
| 21149337 | Dense mapping of IL18 shows no association in SLE. | Guerra SG et al. | 2011 | Human molecular genetics |
| 21160409 | Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. | Petrovski S et al. | 2011 | AIDS (London, England) |
| 21225442 | Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis: protective effect of the T allele and T/T genotype at rs360722. | Sugiura T et al. | 2011 | Modern rheumatology |
| 21241672 | Interleukin-18 promoter polymorphisms and risk of Parkinson's disease in a Han Chinese population. | Xu X et al. | 2011 | Brain research |
| 21395662 | Relationship between single nucleotide polymorphism of interleukin-18 and susceptibility to pulmonary tuberculosis in the Chinese Han population. | Han M et al. | 2011 | Microbiology and immunology |
| 21470492 | Interleukin-18 promoter polymorphisms in patients with systemic lupus erythematosus. | Warchoł T et al. | 2011 | Clinical and experimental rheumatology |
| 21532063 | IL18 polymorphism is associated with Behçet's disease but not lupus in patients from Turkey. | Htoon J et al. | 2011 | The Journal of rheumatology |
| 21611751 | Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis. | Ma Y et al. | 2012 | Molecular biology reports |
| 21742843 | Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans. | Haralambieva IH et al. | 2011 | The Journal of infectious diseases |
| 21775533 | Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy. | Tan XL et al. | 2011 | Clinical cancer research |
| 21962565 | Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events. | Haastrup E et al. | 2012 | Journal of affective disorders |
| 21969001 | Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality. | Anyona SB et al. | 2011 | Infection and immunity |
| 21984735 | High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection. | Chattergoon MA et al. | 2011 | The Journal of infectious diseases |
| 22008665 | The associations of IL-18 serum levels and promoter polymorphism with tacrolimus pharmacokinetics and hepatic allograft dysfunction in Chinese liver transplantation recipients. | Li Y et al. | 2012 | Gene |
| 22136483 | Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. | Hulin-Curtis SL et al. | 2012 | International journal of immunogenetics |
| 22141572 | Circulating levels of IL-18 are significantly influenced by the IL-18 +183 A/G polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an observational study. | Opstad TB et al. | 2011 | Cardiovascular diabetology |
| 22300735 | Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factors. | Hildesheim A et al. | 2012 | Seminars in cancer biology |
| 22325058 | Association of polymorphisms in interleukin-18 and interleukin-28B with hepatitis B recurrence after liver transplantation in Chinese Han population. | Li Y et al. | 2012 | International journal of immunogenetics |
| 22649680 | Association of cytokine gene alleles with the inflammation of human periodontal tissue. | Safonova AV et al. | 2011 | Acta naturae |
| 22664470 | Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma. | Babar M et al. | 2012 | The American journal of gastroenterology |
| 23073298 | The IL18 gene and Hashimoto thyroiditis in children. | Huang CY et al. | 2013 | Human immunology |
| 23153245 | Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis. | Chen S et al. | 2012 | BMC medical genetics |
| 23238919 | Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis. | Song GG et al. | 2013 | Molecular biology reports |
| 23302036 | Gender-specific association of the interleukin 18 gene with symptomatic gallstone disease. | Shih SC et al. | 2013 | Journal of gastroenterology and hepatology |
| 23557801 | Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients. | Tavares NA et al. | 2013 | Cytokine |
| 23587914 | Interleukin-18 gene polymorphisms and rheumatoid arthritis: a meta-analysis. | Ji JD et al. | 2013 | Gene |
| 24176007 | Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population. | Yang Y et al. | 2013 | BMC infectious diseases |
| 24281113 | Inflammatory genetic markers of prostate cancer risk. | Tindall EA et al. | 2010 | Cancers |
| 24349532 | Impact of interleukin-18 polymorphisms -607A/C and -137G/C on oral cancer occurrence and clinical progression. | Tsai HT et al. | 2013 | PloS one |
| 24621393 | Genetic polymorphisms in the IL-18 gene and ulcerative colitis risk: a meta-analysis. | Wang Y et al. | 2014 | DNA and cell biology |
| 24898701 | Functional polymorphisms of interleukin-18 gene and risk of breast cancer in a Brazilian population. | Back LK et al. | 2014 | Tissue antigens |
| 24969483 | IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case-control studies. | Yu XL et al. | 2014 | Molecular biology reports |
| 24976707 | Human genes involved in hepatitis B virus infection. | Zeng Z et al. | 2014 | World journal of gastroenterology |
| 25061809 | Analyzing genome-wide association studies with an FDR controlling modification of the Bayesian Information Criterion. | Dolejsi E et al. | 2014 | PloS one |
| 25192895 | Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis. | Cai LP et al. | 2014 | Molecular biology reports |
| 25374428 | Interleukin-18 gene promoter polymorphisms and celiac disease in Italian patients. | Zupin L et al. | 2015 | Molecular biology reports |
| 25487141 | Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients. | Xing J et al. | 2015 | European journal of clinical pharmacology |
| 25690033 | Genetic variant in interleukin-18 is associated with idiopathic recurrent miscarriage in Chinese Han population. | Yue J et al. | 2015 | International journal of molecular sciences |
| 25712187 | Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies. | Fan J et al. | 2015 | Pharmacogenomics |
| 26026656 | Ethnicity-stratified analysis of the association between IL-18 polymorphisms and systemic lupus erythematosus in a European population: a meta-analysis. | Guo BR et al. | 2015 | Archives of dermatological research |
| 26041375 | A gene-disease association study of IL18 in thyroid cancer: genotype and haplotype analyses. | Abdolahi F et al. | 2015 | Endocrine |
| 26042207 | Association between interleukin-18 gene promoter (- 607C/A and - 137G/C) polymorphisms and chronic hepatitis C virus infections: A meta-analysis. | Yang Y et al. | 2015 | Meta gene |
| 26096341 | Association between interleukin-18 gene polymorphism and Helicobacter pylori infection in the Korean population. | Myung DS et al. | 2015 | Scientific reports |
| 26116895 | Interleukin-18 promoter -607 C/A and -137 G/C polymorphisms and susceptibility to type 1 diabetes: A meta-analysis. | Lee YH et al. | 2015 | Human immunology |
| 26213495 | Association between IL-18 polymorphisms, serum levels, and HBV-related hepatocellular carcinoma in a Chinese population: a retrospective case-control study. | Bao J et al. | 2015 | Cancer cell international |
| 26229413 | Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn's disease. | Gao SJ et al. | 2015 | World journal of gastroenterology |
| 26445852 | Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis. | Findlay JM et al. | 2016 | Digestive diseases and sciences |
| 26486291 | ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON. | Santos KN et al. | 2015 | Arquivos de gastroenterologia |
| 26690141 | IL-18 and Cutaneous Inflammatory Diseases. | Lee JH et al. | 2015 | International journal of molecular sciences |
| 26698117 | Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort. | Bank S et al. | 2015 | PloS one |
| 26800664 | Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet's disease : A meta-analysis. | Xu Y et al. | 2016 | Zeitschrift fur Rheumatologie |
| 26830320 | Lack of association between IL-10 and IL-18 gene promoter polymorphisms and Parkinson's disease with cognitive impairment in a Chinese population. | Liu Z et al. | 2016 | Scientific reports |
| 27027876 | IL18 Gene Variants Influence the Susceptibility to Chagas Disease. | Leon Rodriguez DA et al. | 2016 | PLoS neglected tropical diseases |
| 27028244 | Interleukin 18 -607 A/C Gene Polymorphism is Associated With Susceptibility to IgA Nephropathy in a Chinese Han Population. | Yang B et al. | 2017 | Applied immunohistochemistry & molecular morphology |
| 27054030 | The dual roles of cytokines in Alzheimer's disease: update on interleukins, TNF-α, TGF-β and IFN-γ. | Zheng C et al. | 2016 | Translational neurodegeneration |
| 27098064 | Association of interleukin-1 family cytokines single nucleotide polymorphisms with susceptibility to systemic sclerosis: an independent case-control study and a meta-analysis. | Huang XL et al. | 2016 | Immunologic research |
| 27352267 | Interleukin-10.rs1800896 and Interleukin-18.rs1946518 gene polymorphisms could not predict the outcome of hepatitis C virus infection in Egyptian patients treated with pegylated interferon plus ribavirin. | Abdelraheem WM et al. | 2016 | Archives of virology |
| 27419078 | Interleukin-18 gene promoter 607A polymorphism, but not 137C polymorphism, is a protective factor for ischemic stroke in the Chinese population: A meta-analysis. | Zhang MJ et al. | 2016 | Meta gene |
| 27430614 | A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men. | Swartz JR et al. | 2017 | Neuropsychopharmacology |
| 27483258 | Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis. | Kim JE et al. | 2016 | International journal of molecular sciences |
| 27536357 | Genetic susceptibility to Barrett's oesophagus: Lessons from early studies. | Findlay JM et al. | 2016 | United European gastroenterology journal |
| 27703550 | Serum Interleukin-18 and Its Gene Haplotypes Profile as Predictors in Patients with Diabetic Nephropathy. | Elneam AI et al. | 2016 | Open access Macedonian journal of medical sciences |
| 27775096 | Genetic analysis of innate immunity in Behcet's disease identifies an association with IL-37 and IL-18RAP. | Tan H et al. | 2016 | Scientific reports |
| 27928589 | Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia. | Wang H et al. | 2017 | Inflammation research |
| 28000712 | Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma. | Zhu SL et al. | 2016 | Scientific reports |
| 28139755 | Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy. | Bank S et al. | 2018 | The pharmacogenomics journal |
| 28246425 | Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients. | Zhang X et al. | 2017 | Disease markers |
| 28580570 | IL16 and IL18 gene polymorphisms in women with gestational diabetes. | Tarnowski M et al. | 2017 | Ginekologia polska |
| 28692122 | Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand. | Tungtrongchitr A et al. | 2017 | Genetics and molecular research |
| 28834572 | Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations. | Chen J et al. | 2018 | Journal of clinical laboratory analysis |
| 29061223 | Association between donor and recipient Interleukin-18 gene polymorphisms and the risk of infection after liver transplantation. | Shi BJ et al. | 2017 | Clinical and investigative medicine. Medecine clinique et experimentale |
| 29097263 | The genetic polymorphism and expression profiles of NLRP3 inflammasome in patients with chronic myeloid leukemia. | Zhang A et al. | 2018 | Human immunology |
| 29129846 | The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study. | Tanaka K et al. | 2017 | The Tohoku journal of experimental medicine |
| 29136357 | Association of cytokine gene polymorphisms with bronchopulmonary dysplasia in Han Chinese newborns. | Chen H et al. | 2018 | Pediatric pulmonology |
| 29312552 | NLRP3 inflammasome activation plays a carcinogenic role through effector cytokine IL-18 in lymphoma. | Zhao X et al. | 2017 | Oncotarget |
| 29349811 | Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata. | Celik SD et al. | 2018 | Journal of clinical laboratory analysis |
| 29403300 | Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression. | Mitrokhin V et al. | 2018 | Journal of inflammation research |
| 29743792 | Effect of Sofosbuvir Plus Daclatasvir in Hepatitis C Virus Genotype-4 Patients: Promising Effect on Liver Fibrosis. | Abdel-Aziz AM et al. | 2018 | Journal of clinical and experimental hepatology |
| 30059753 | Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children. | Liang J et al. | 2018 | Gene |
| 30310516 | Systematic Review and Meta-Analysis on the Association between Polymorphisms in Genes of IL-12 Signaling Pathway and Hepatocellular Carcinoma Risk. | Xiao Y et al. | 2018 | Journal of Cancer |
| 30412745 | Genetic variations in inflammation-related genes and their influence on the susceptibility of pediatric acute lung injury in a Chinese population. | Zhao X et al. | 2019 | Gene |
| 30526181 | Association of IL-10, IL-18, and IL-33 genetic polymorphisms with recurrent pregnancy loss risk in Iranian women. | Soheilyfar S et al. | 2019 | Gynecological endocrinology |
| 30728751 | Inflammasome Genes' Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment. | Estfanous SZK et al. | 2019 | Mediators of inflammation |
| 30775053 | IL18 Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians. | Boëchat-Fernandes A et al. | 2019 | Journal of pediatric genetics |
| 30781715 | Genetic Epidemiology of Breast Cancer in Latin America. | Zavala VA et al. | 2019 | Genes |
| 30811631 | Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease. | Bank S et al. | 2019 | Alimentary pharmacology & therapeutics |
| 30893922 | Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles. | Wu CH et al. | 2019 | International journal of environmental research and public health |
| 31065235 | IL18 Polymorphism and Periodontitis Susceptibility, Regardless of IL12B, MMP9, and Smoking Habits. | Tsuneto PY et al. | 2019 | Mediators of inflammation |
| 31301271 | Lack of significant effect of interleukin-18 gene variants on tuberculosis susceptibility in the Polish population. | Wawrocki S et al. | 2019 | Acta biochimica Polonica |
| 31364314 | Genetics of recurrent pregnancy loss among Iranian population. | Moghbeli M et al. | 2019 | Molecular genetics & genomic medicine |
| 31428046 | Investigation of NF-κB-94ins/del ATTG and CARD8 (rs2043211) Gene Polymorphism in Acute Lymphoblastic Leukemia. | Zhang C et al. | 2019 | Frontiers in endocrinology |
| 31660404 | Impacts of Interleukin-18 Polymorphisms on the Incidence of Delayed-Onset Cytomegalovirus Infection in a Cohort of Kidney Transplant Recipients. | Pérez-Flores I et al. | 2019 | Open forum infectious diseases |
| 31676365 | Associations of polymorphisms in IL-6 and IL-18 with tuberculosis: Evidence from a meta-analysis. | He C et al. | 2020 | Microbial pathogenesis |
| 31698031 | Associations of genetic polymorphisms in CTLA-4 and IL-18 with chronic liver diseases: Evidence from a meta-analysis. | Zhang S et al. | 2020 | Genomics |
| 31736573 | Interleukin 18 Polymorphisms and its serum level in Patients with Multiple Sclerosis. | Jahanbani-Ardakani H et al. | 2019 | Annals of Indian Academy of Neurology |
| 31751351 | Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. | Strauss M et al. | 2019 | PLoS neglected tropical diseases |
| 31801640 | Relationship of genetic polymorphisms in CTLA-4 and IL-18 with viral hepatitis: evidence from a meta-analysis. | Yu Y et al. | 2019 | Epidemiology and infection |
| 31830994 | Associations between twelve common gene polymorphisms and susceptibility to hepatocellular carcinoma: evidence from a meta-analysis. | Quan Y et al. | 2019 | World journal of surgical oncology |
| 31868208 | Associations of polymorphisms in CTLA-4 and IL-18 with liver diseases: evidence from a meta-analysis. | Zhang S et al. | 2019 | Bioscience reports |
| 31871417 | Genetic association of interleukin 18 (-607C/A, rs1946518) single nucleotide polymorphism with asthmatic children, disease severity and total IgE serum level. | Ezzat DA et al. | 2019 | Central-European journal of immunology |
| 31931428 | Plasma levels of Interleukin 18 but not amyloid-β or Tau are elevated in female depressive patients. | Liu FR et al. | 2020 | Comprehensive psychiatry |
| 31935498 | A comprehensive evaluation of single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Asian populations: A systematic review and network meta-analysis. | Zhang C et al. | 2020 | Gene |
| 32045661 | Genetic variation at the interleukin-18 locus is associated with wheat-dependent exercise-induced anaphylaxis in the Han Chinese population. | Gao X et al. | 2020 | Gene |
| 32133331 | Risk of Necrotizing Enterocolitis Associated With the Single Nucleotide Polymorphisms VEGF C-2578A, IL-18 C-607A, and IL-4 Receptor α-Chain A-1902G: A Validation Study in a Prospective Multicenter Cohort. | Moonen RM et al. | 2020 | Frontiers in pediatrics |
| 32160807 | IL-10, IL-18 Gene Polymorphisms Might Influence Predisposition to Coronary Artery Disease in East Asians: A Meta-Analysis. | Zheng J et al. | 2021 | Immunological investigations |
| 32163880 | Associations of polymorphisms in interleukins with susceptibility to breast cancer: Evidence from a meta-analysis. | Xu G et al. | 2020 | Cytokine |
| 32245311 | Association of rs1946518 C/A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women: A Case-control Study. | Fathi Maroufi N et al. | 2019 | Iranian journal of allergy, asthma, and immunology |
| 32529476 | The association between IL18, FOXP3 and IL13 genes polymorphisms and risk of allergic rhinitis: a meta-analysis. | Tang L et al. | 2020 | Inflammation research |
| 32543936 | Impact of IL-17F 7488T/C Functional Polymorphism on Progressive Rheumatoid Arthritis: Novel Insight from the Molecular Dynamic Simulations. | Nisar H et al. | 2021 | Immunological investigations |
| 32633568 | Genetic polymorphisms -137 (G > C) (rs187238) and -607 (C > A) (rs1946518) and serum level of interleukin 18 in Fars ethnic groups with metabolic syndrome in Northern Iran. | Aghajani R et al. | 2022 | Archives of physiology and biochemistry |
| 32781445 | Predisposition of Inflammatory Bowel Disease Is Influenced by IL-8, IL-10, and IL-18 Polymorphisms: A Meta-Analysis. | Su Y et al. | 2020 | International archives of allergy and immunology |
| 32847380 | Associations between Gene Polymorphisms in Pro-inflammatory Cytokines and the Risk of Inflammatory Bowel Disease: A Meta-analysis. | Liu W et al. | 2021 | Immunological investigations |
| 32981742 | Genetic polymorphisms and expression of NLRP3 inflammasome-related genes are associated with Philadelphia chromosome-negative myeloproliferative neoplasms. | Zhou Y et al. | 2020 | Human immunology |
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Help
The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.
Genome context:
Select flank length:
Genomic regions, transcripts, and products
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Help
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.