Name: rs662
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs662

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr7:95308134 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: T>A / T>C / T>G
Variation Type: SNV Single Nucleotide Variation
Frequency: C=0.315298 (111601/353954, ALFA)
C=0.445619 (117951/264690, TOPMED)
C=0.378433 (95101/251302, GnomAD_exome) (+ 25 more)
C=0.422151 (59042/139860, GnomAD)
C=0.377047 (45735/121298, ExAC)
T=0.42875 (33741/78696, PAGE_STUDY)
T=0.33389 (9435/28258, 14KJPN)
T=0.33548 (5622/16758, 8.3KJPN)
T=0.4572 (2928/6404, 1000G_30x)
T=0.4571 (2289/5008, 1000G)
C=0.2480 (1111/4480, Estonian)
C=0.2903 (1119/3854, ALSPAC)
C=0.2789 (1034/3708, TWINSUK)
T=0.3382 (991/2930, KOREAN)
C=0.4914 (1024/2084, HGDP_Stanford)
T=0.4279 (807/1886, HapMap)
C=0.3014 (337/1118, Daghestan)
C=0.284 (283/998, GoNL)
T=0.295 (181/614, Vietnamese)
C=0.253 (152/600, NorthernSweden)
C=0.307 (164/534, MGP)
T=0.268 (107/400, SGDP_PRJ)
T=0.492 (174/354, PharmGKB)
C=0.276 (84/304, FINRISK)
C=0.380 (82/216, Qatari)
T=0.35 (16/46, Siberian)
C=0.30 (12/40, GENOME_DK)
C=0.21 (6/28, Ancient Sardinia)

Clinical Significance: Reported in ClinVar
Gene : Consequence: PON1 : Missense Variant
Publications: 218 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20231103111315

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	370172	T=0.680581	C=0.319419, G=0.000000
European	Sub	309438	T=0.714166	C=0.285834, G=0.000000
African	Sub	16092	T=0.34819	C=0.65181, G=0.00000
African Others	Sub	572	T=0.260	C=0.740, G=0.000
African American	Sub	15520	T=0.35142	C=0.64858, G=0.00000
Asian	Sub	6934	T=0.3490	C=0.6510, G=0.0000
East Asian	Sub	4966	T=0.3592	C=0.6408, G=0.0000
Other Asian	Sub	1968	T=0.3232	C=0.6768, G=0.0000
Latin American 1	Sub	1488	T=0.5524	C=0.4476, G=0.0000
Latin American 2	Sub	7236	T=0.5231	C=0.4769, G=0.0000
South Asian	Sub	5226	T=0.6207	C=0.3793, G=0.0000
Other	Sub	23758	T=0.63423	C=0.36577, G=0.00000

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
Allele Frequency Aggregator	Total	Global	353954	T=0.684702	C=0.315298, G=0.000000
Allele Frequency Aggregator	European	Sub	299486	T=0.714384	C=0.285616, G=0.000000
Allele Frequency Aggregator	Other	Sub	22318	T=0.63406	C=0.36594, G=0.00000
Allele Frequency Aggregator	African	Sub	11266	T=0.35354	C=0.64646, G=0.00000
Allele Frequency Aggregator	Latin American 2	Sub	7236	T=0.5231	C=0.4769, G=0.0000
Allele Frequency Aggregator	Asian	Sub	6934	T=0.3490	C=0.6510, G=0.0000
Allele Frequency Aggregator	South Asian	Sub	5226	T=0.6207	C=0.3793, G=0.0000
Allele Frequency Aggregator	Latin American 1	Sub	1488	T=0.5524	C=0.4476, G=0.0000
TopMed	Global	Study-wide	264690	T=0.554381	C=0.445619
gnomAD - Exomes	Global	Study-wide	251302	T=0.621567	C=0.378433
gnomAD - Exomes	European	Sub	135270	T=0.719354	C=0.280646
gnomAD - Exomes	Asian	Sub	49000	T=0.51363	C=0.48637
gnomAD - Exomes	American	Sub	34574	T=0.50480	C=0.49520
gnomAD - Exomes	African	Sub	16256	T=0.32124	C=0.67876
gnomAD - Exomes	Ashkenazi Jewish	Sub	10074	T=0.69267	C=0.30733
gnomAD - Exomes	Other	Sub	6128	T=0.6647	C=0.3353
gnomAD - Genomes	Global	Study-wide	139860	T=0.577849	C=0.422151
gnomAD - Genomes	European	Sub	75816	T=0.71612	C=0.28388
gnomAD - Genomes	African	Sub	41830	T=0.33392	C=0.66608
gnomAD - Genomes	American	Sub	13622	T=0.58281	C=0.41719
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	T=0.6764	C=0.3236
gnomAD - Genomes	East Asian	Sub	3122	T=0.3725	C=0.6275
gnomAD - Genomes	Other	Sub	2148	T=0.5624	C=0.4376
ExAC	Global	Study-wide	121298	T=0.622953	C=0.377047
ExAC	Europe	Sub	73292	T=0.72067	C=0.27933
ExAC	Asian	Sub	25134	T=0.51950	C=0.48050
ExAC	American	Sub	11558	T=0.48936	C=0.51064
ExAC	African	Sub	10406	T=0.32770	C=0.67230
ExAC	Other	Sub	908	T=0.684	C=0.316
The PAGE Study	Global	Study-wide	78696	T=0.42875	C=0.57125
The PAGE Study	AfricanAmerican	Sub	32514	T=0.34111	C=0.65889
The PAGE Study	Mexican	Sub	10808	T=0.51832	C=0.48168
The PAGE Study	Asian	Sub	8318	T=0.3467	C=0.6533
The PAGE Study	PuertoRican	Sub	7918	T=0.5402	C=0.4598
The PAGE Study	NativeHawaiian	Sub	4534	T=0.3851	C=0.6149
The PAGE Study	Cuban	Sub	4228	T=0.6308	C=0.3692
The PAGE Study	Dominican	Sub	3828	T=0.4976	C=0.5024
The PAGE Study	CentralAmerican	Sub	2450	T=0.4971	C=0.5029
The PAGE Study	SouthAmerican	Sub	1982	T=0.5489	C=0.4511
The PAGE Study	NativeAmerican	Sub	1260	T=0.6032	C=0.3968
The PAGE Study	SouthAsian	Sub	856	T=0.588	C=0.412
14KJPN	JAPANESE	Study-wide	28258	T=0.33389	C=0.66611
8.3KJPN	JAPANESE	Study-wide	16758	T=0.33548	C=0.66452
1000Genomes_30x	Global	Study-wide	6404	T=0.4572	C=0.5428
1000Genomes_30x	African	Sub	1786	T=0.2520	C=0.7480
1000Genomes_30x	Europe	Sub	1266	T=0.7038	C=0.2962
1000Genomes_30x	South Asian	Sub	1202	T=0.5857	C=0.4143
1000Genomes_30x	East Asian	Sub	1170	T=0.3359	C=0.6641
1000Genomes_30x	American	Sub	980	T=0.500	C=0.500
1000Genomes	Global	Study-wide	5008	T=0.4571	C=0.5429
1000Genomes	African	Sub	1322	T=0.2474	C=0.7526
1000Genomes	East Asian	Sub	1008	T=0.3343	C=0.6657
1000Genomes	Europe	Sub	1006	T=0.7097	C=0.2903
1000Genomes	South Asian	Sub	978	T=0.576	C=0.424
1000Genomes	American	Sub	694	T=0.501	C=0.499
Genetic variation in the Estonian population	Estonian	Study-wide	4480	T=0.7520	C=0.2480
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.7097	C=0.2903
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.7211	C=0.2789
KOREAN population from KRGDB	KOREAN	Study-wide	2930	T=0.3382	A=0.0000, C=0.6618, G=0.0000
HGDP-CEPH-db Supplement 1	Global	Study-wide	2084	T=0.5086	C=0.4914
HGDP-CEPH-db Supplement 1	Est_Asia	Sub	470	T=0.360	C=0.640
HGDP-CEPH-db Supplement 1	Central_South_Asia	Sub	414	T=0.708	C=0.292
HGDP-CEPH-db Supplement 1	Middle_Est	Sub	350	T=0.663	C=0.337
HGDP-CEPH-db Supplement 1	Europe	Sub	320	T=0.697	C=0.303
HGDP-CEPH-db Supplement 1	Africa	Sub	242	T=0.198	C=0.802
HGDP-CEPH-db Supplement 1	America	Sub	216	T=0.407	C=0.593
HGDP-CEPH-db Supplement 1	Oceania	Sub	72	T=0.10	C=0.90
HapMap	Global	Study-wide	1886	T=0.4279	C=0.5721
HapMap	American	Sub	768	T=0.538	C=0.462
HapMap	African	Sub	692	T=0.266	C=0.734
HapMap	Asian	Sub	250	T=0.308	C=0.692
HapMap	Europe	Sub	176	T=0.756	C=0.244
Genome-wide autozygosity in Daghestan	Global	Study-wide	1118	T=0.6986	C=0.3014
Genome-wide autozygosity in Daghestan	Daghestan	Sub	622	T=0.741	C=0.259
Genome-wide autozygosity in Daghestan	Near_East	Sub	142	T=0.725	C=0.275
Genome-wide autozygosity in Daghestan	Central Asia	Sub	120	T=0.583	C=0.417
Genome-wide autozygosity in Daghestan	Europe	Sub	108	T=0.648	C=0.352
Genome-wide autozygosity in Daghestan	South Asian	Sub	90	T=0.60	C=0.40
Genome-wide autozygosity in Daghestan	Caucasus	Sub	36	T=0.64	C=0.36
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	T=0.716	C=0.284
A Vietnamese Genetic Variation Database	Global	Study-wide	614	T=0.295	C=0.705
Northern Sweden	ACPOP	Study-wide	600	T=0.747	C=0.253
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	T=0.693	C=0.307
SGDP_PRJ	Global	Study-wide	400	T=0.268	C=0.733
PharmGKB Aggregated	Global	Study-wide	354	T=0.492	C=0.508
PharmGKB Aggregated	PA149836975	Sub	354	T=0.492	C=0.508
FINRISK	Finnish from FINRISK project	Study-wide	304	T=0.724	C=0.276
Qatari	Global	Study-wide	216	T=0.620	C=0.380
Siberian	Global	Study-wide	46	T=0.35	C=0.65
The Danish reference pan genome	Danish	Study-wide	40	T=0.70	C=0.30
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	28	T=0.79	C=0.21

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 7	NC_000007.14:g.95308134T>A
GRCh38.p14 chr 7	NC_000007.14:g.95308134T>C
GRCh38.p14 chr 7	NC_000007.14:g.95308134T>G
GRCh37.p13 chr 7	NC_000007.13:g.94937446T>A
GRCh37.p13 chr 7	NC_000007.13:g.94937446T>C
GRCh37.p13 chr 7	NC_000007.13:g.94937446T>G
PON1 RefSeqGene	NG_008779.2:g.21573A>T
PON1 RefSeqGene	NG_008779.2:g.21573A>G
PON1 RefSeqGene	NG_008779.2:g.21573A>C

Gene: PON1, paraoxonase 1 (minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
PON1 transcript	NM_000446.7:c.575A>T	Q [CAA] > L [CTA]	Coding Sequence Variant
serum paraoxonase/arylesterase 1	NP_000437.3:p.Gln192Leu	Q (Gln) > L (Leu)	Missense Variant
PON1 transcript	NM_000446.7:c.575A>G	Q [CAA] > R [CGA]	Coding Sequence Variant
serum paraoxonase/arylesterase 1	NP_000437.3:p.Gln192Arg	Q (Gln) > R (Arg)	Missense Variant
PON1 transcript	NM_000446.7:c.575A>C	Q [CAA] > P [CCA]	Coding Sequence Variant
serum paraoxonase/arylesterase 1	NP_000437.3:p.Gln192Pro	Q (Gln) > P (Pro)	Missense Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: C (allele ID: 28774 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000014739.2	Coronary artery disease, susceptibility to	Risk-Factor
RCV000014740.2	Coronary artery spasm 2, susceptibility to	Risk-Factor
RCV000133464.2	Enzyme activity finding	Association
RCV001618211.3	not provided	Benign

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	T=	A	C	G
GRCh38.p14 chr 7	NC_000007.14:g.95308134=	NC_000007.14:g.95308134T>A	NC_000007.14:g.95308134T>C	NC_000007.14:g.95308134T>G
GRCh37.p13 chr 7	NC_000007.13:g.94937446=	NC_000007.13:g.94937446T>A	NC_000007.13:g.94937446T>C	NC_000007.13:g.94937446T>G
PON1 RefSeqGene	NG_008779.2:g.21573=	NG_008779.2:g.21573A>T	NG_008779.2:g.21573A>G	NG_008779.2:g.21573A>C
PON1 transcript	NM_000446.7:c.575=	NM_000446.7:c.575A>T	NM_000446.7:c.575A>G	NM_000446.7:c.575A>C
PON1 transcript	NM_000446.6:c.575=	NM_000446.6:c.575A>T	NM_000446.6:c.575A>G	NM_000446.6:c.575A>C
PON1 transcript	NM_000446.5:c.575=	NM_000446.5:c.575A>T	NM_000446.5:c.575A>G	NM_000446.5:c.575A>C
serum paraoxonase/arylesterase 1	NP_000437.3:p.Gln192=	NP_000437.3:p.Gln192Leu	NP_000437.3:p.Gln192Arg	NP_000437.3:p.Gln192Pro

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

199 SubSNP, 28 Frequency, 4 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	WIAF	ss667	Sep 19, 2000 (36)
2	HU-CHINA	ss4573	Sep 19, 2000 (36)
3	PGA-UW-FHCRC	ss5111592	Oct 08, 2002 (108)
4	SNP500CANCER	ss5586846	Mar 31, 2003 (113)
5	WIPGA	ss16338591	Feb 28, 2004 (123)
6	IMCJ-GDT	ss22887814	Apr 05, 2004 (123)
7	PERLEGEN	ss24194186	Sep 20, 2004 (123)
8	ABI	ss44784258	Mar 13, 2006 (126)
9	APPLERA_GI	ss48403354	Mar 13, 2006 (126)
10	PGA-UW-FHCRC	ss52088340	Oct 16, 2006 (127)
11	ILLUMINA	ss65728920	Oct 16, 2006 (127)
12	ILLUMINA	ss66688093	Dec 01, 2006 (127)
13	ILLUMINA	ss67479587	Dec 01, 2006 (127)
14	ILLUMINA	ss67836117	Dec 01, 2006 (127)
15	SHGC	ss68074398	Dec 01, 2006 (127)
16	PERLEGEN	ss69022647	May 18, 2007 (127)
17	ILLUMINA	ss70876924	May 26, 2008 (130)
18	ILLUMINA	ss71466808	May 18, 2007 (127)
19	AFFY	ss74820980	Aug 16, 2007 (128)
20	ILLUMINA	ss75593740	Dec 06, 2007 (129)
21	ILLUMINA	ss79228198	Dec 15, 2007 (130)
22	HGSV	ss81402884	Dec 15, 2007 (130)
23	KRIBB_YJKIM	ss83344243	Dec 15, 2007 (130)
24	PHARMGKB_AB_DME	ss84167939	Dec 15, 2007 (130)
25	BCMHGSC_JDW	ss93729745	Mar 24, 2008 (129)
26	HUMANGENOME_JCVI	ss98319688	Feb 06, 2009 (130)
27	SHGC	ss99307843	Feb 06, 2009 (130)
28	BGI	ss104451531	Dec 01, 2009 (131)
29	KRIBB_YJKIM	ss104796374	Feb 06, 2009 (130)
30	1000GENOMES	ss112370132	Jan 25, 2009 (130)
31	ILLUMINA-UK	ss116203131	Feb 14, 2009 (130)
32	ILLUMINA	ss122584545	Dec 01, 2009 (131)
33	ENSEMBL	ss142695412	Dec 01, 2009 (131)
34	ILLUMINA	ss154372324	Dec 01, 2009 (131)
35	GMI	ss155213711	Dec 01, 2009 (131)
36	ILLUMINA	ss159548363	Dec 01, 2009 (131)
37	SEATTLESEQ	ss159715171	Dec 01, 2009 (131)
38	ILLUMINA	ss160792630	Dec 01, 2009 (131)
39	COMPLETE_GENOMICS	ss162541332	Jul 04, 2010 (132)
40	ILLUMINA	ss172162609	Jul 04, 2010 (132)
41	ILLUMINA	ss174049515	Jul 04, 2010 (132)
42	BUSHMAN	ss197934610	Jul 04, 2010 (132)
43	ILLUMINA	ss209091348	Jul 04, 2010 (132)
44	1000GENOMES	ss223213228	Jul 14, 2010 (132)
45	1000GENOMES	ss234081981	Jul 15, 2010 (132)
46	1000GENOMES	ss241016622	Jul 15, 2010 (132)
47	OMICIA	ss244238655	Aug 29, 2012 (137)
48	ILLUMINA	ss244305694	Jul 04, 2010 (132)
49	OMIM-CURATED-RECORDS	ss256302371	Aug 26, 2010 (132)
50	GMI	ss279445043	May 04, 2012 (137)
51	GMI	ss285679181	Apr 25, 2013 (138)
52	PJP	ss293919126	May 09, 2011 (134)
53	NHLBI-ESP	ss342239743	May 09, 2011 (134)
54	ILLUMINA	ss481300812	May 04, 2012 (137)
55	ILLUMINA	ss481325655	May 04, 2012 (137)
56	ILLUMINA	ss482308219	Sep 08, 2015 (146)
57	ILLUMINA	ss485445634	May 04, 2012 (137)
58	1000GENOMES	ss490949017	May 04, 2012 (137)
59	EXOME_CHIP	ss491401880	May 04, 2012 (137)
60	CLINSEQ_SNP	ss491909923	May 04, 2012 (137)
61	ILLUMINA	ss537371502	Sep 08, 2015 (146)
62	TISHKOFF	ss560164731	Apr 25, 2013 (138)
63	SSMP	ss654566924	Apr 25, 2013 (138)
64	ILLUMINA	ss778574597	Sep 08, 2015 (146)
65	ILLUMINA	ss780861423	Aug 21, 2014 (142)
66	ILLUMINA	ss783168268	Sep 08, 2015 (146)
67	ILLUMINA	ss783545874	Aug 21, 2014 (142)
68	ILLUMINA	ss784123875	Sep 08, 2015 (146)
69	ILLUMINA	ss825558716	Apr 01, 2015 (144)
70	ILLUMINA	ss832427755	Sep 08, 2015 (146)
71	ILLUMINA	ss833059547	Jul 13, 2019 (153)
72	ILLUMINA	ss834031654	Sep 08, 2015 (146)
73	JMKIDD_LAB	ss974464988	Aug 21, 2014 (142)
74	EVA-GONL	ss984559359	Aug 21, 2014 (142)
75	JMKIDD_LAB	ss1067489812	Aug 21, 2014 (142)
76	JMKIDD_LAB	ss1074809689	Aug 21, 2014 (142)
77	1000GENOMES	ss1326218939	Aug 21, 2014 (142)
78	HAMMER_LAB	ss1397500758	Sep 08, 2015 (146)
79	DDI	ss1431213383	Apr 01, 2015 (144)
80	EVA_GENOME_DK	ss1582313008	Apr 01, 2015 (144)
81	EVA_FINRISK	ss1584053539	Apr 01, 2015 (144)
82	EVA_DECODE	ss1594137457	Apr 01, 2015 (144)
83	EVA_UK10K_ALSPAC	ss1618737743	Apr 01, 2015 (144)
84	EVA_UK10K_TWINSUK	ss1661731776	Apr 01, 2015 (144)
85	EVA_EXAC	ss1688823947	Apr 01, 2015 (144)
86	EVA_MGP	ss1711171940	Apr 01, 2015 (144)
87	EVA_SVP	ss1712972386	Apr 01, 2015 (144)
88	ILLUMINA	ss1752701004	Sep 08, 2015 (146)
89	ILLUMINA	ss1752701005	Sep 08, 2015 (146)
90	HAMMER_LAB	ss1805119698	Sep 08, 2015 (146)
91	ILLUMINA	ss1917819156	Feb 12, 2016 (147)
92	WEILL_CORNELL_DGM	ss1927818941	Feb 12, 2016 (147)
93	ILLUMINA	ss1946214555	Feb 12, 2016 (147)
94	ILLUMINA	ss1946214556	Feb 12, 2016 (147)
95	ILLUMINA	ss1959033124	Feb 12, 2016 (147)
96	GENOMED	ss1970764838	Jul 19, 2016 (147)
97	JJLAB	ss2024592586	Sep 14, 2016 (149)
98	USC_VALOUEV	ss2152813932	Dec 20, 2016 (150)
99	HUMAN_LONGEVITY	ss2295963308	Dec 20, 2016 (150)
100	SYSTEMSBIOZJU	ss2626788522	Nov 08, 2017 (151)
101	ILLUMINA	ss2634634581	Nov 08, 2017 (151)
102	ILLUMINA	ss2634634582	Nov 08, 2017 (151)
103	ILLUMINA	ss2635174600	Nov 08, 2017 (151)
104	GRF	ss2708522481	Nov 08, 2017 (151)
105	GNOMAD	ss2736571821	Nov 08, 2017 (151)
106	GNOMAD	ss2747863415	Nov 08, 2017 (151)
107	GNOMAD	ss2856417529	Nov 08, 2017 (151)
108	AFFY	ss2985412835	Nov 08, 2017 (151)
109	AFFY	ss2986044793	Nov 08, 2017 (151)
110	SWEGEN	ss3001657597	Nov 08, 2017 (151)
111	ILLUMINA	ss3022758147	Nov 08, 2017 (151)
112	ILLUMINA	ss3022758148	Nov 08, 2017 (151)
113	EVA_SAMSUNG_MC	ss3023063115	Nov 08, 2017 (151)
114	BIOINF_KMB_FNS_UNIBA	ss3026089160	Nov 08, 2017 (151)
115	CSHL	ss3347738528	Nov 08, 2017 (151)
116	ILLUMINA	ss3625933189	Oct 12, 2018 (152)
117	ILLUMINA	ss3629866719	Oct 12, 2018 (152)
118	ILLUMINA	ss3629866720	Oct 12, 2018 (152)
119	ILLUMINA	ss3632540396	Oct 12, 2018 (152)
120	ILLUMINA	ss3633471034	Oct 12, 2018 (152)
121	ILLUMINA	ss3634196336	Oct 12, 2018 (152)
122	ILLUMINA	ss3635131448	Oct 12, 2018 (152)
123	ILLUMINA	ss3635131449	Oct 12, 2018 (152)
124	ILLUMINA	ss3635875947	Oct 12, 2018 (152)
125	ILLUMINA	ss3636865192	Oct 12, 2018 (152)
126	ILLUMINA	ss3637628957	Oct 12, 2018 (152)
127	ILLUMINA	ss3638711166	Oct 12, 2018 (152)
128	ILLUMINA	ss3639357667	Oct 12, 2018 (152)
129	ILLUMINA	ss3639707187	Oct 12, 2018 (152)
130	ILLUMINA	ss3640838740	Oct 12, 2018 (152)
131	ILLUMINA	ss3640838741	Oct 12, 2018 (152)
132	ILLUMINA	ss3641216509	Oct 12, 2018 (152)
133	ILLUMINA	ss3641514015	Oct 12, 2018 (152)
134	ILLUMINA	ss3643646067	Oct 12, 2018 (152)
135	ILLUMINA	ss3644947651	Oct 12, 2018 (152)
136	ILLUMINA	ss3644947652	Oct 12, 2018 (152)
137	OMUKHERJEE_ADBS	ss3646359416	Oct 12, 2018 (152)
138	URBANLAB	ss3648704829	Oct 12, 2018 (152)
139	ILLUMINA	ss3653292049	Oct 12, 2018 (152)
140	ILLUMINA	ss3653292050	Oct 12, 2018 (152)
141	ILLUMINA	ss3654174382	Oct 12, 2018 (152)
142	EGCUT_WGS	ss3669416235	Jul 13, 2019 (153)
143	EVA_DECODE	ss3720241136	Jul 13, 2019 (153)
144	ILLUMINA	ss3726463017	Jul 13, 2019 (153)
145	ACPOP	ss3734876368	Jul 13, 2019 (153)
146	ILLUMINA	ss3744293239	Jul 13, 2019 (153)
147	ILLUMINA	ss3744570110	Jul 13, 2019 (153)
148	ILLUMINA	ss3745431479	Jul 13, 2019 (153)
149	ILLUMINA	ss3745431480	Jul 13, 2019 (153)
150	EVA	ss3766889126	Jul 13, 2019 (153)
151	PAGE_CC	ss3771384468	Jul 13, 2019 (153)
152	ILLUMINA	ss3772924352	Jul 13, 2019 (153)
153	ILLUMINA	ss3772924353	Jul 13, 2019 (153)
154	KHV_HUMAN_GENOMES	ss3810061499	Jul 13, 2019 (153)
155	EVA	ss3824292698	Apr 26, 2020 (154)
156	EVA	ss3825524316	Apr 26, 2020 (154)
157	EVA	ss3825540120	Apr 26, 2020 (154)
158	EVA	ss3825723615	Apr 26, 2020 (154)
159	EVA	ss3830707815	Apr 26, 2020 (154)
160	EVA	ss3838852563	Apr 26, 2020 (154)
161	EVA	ss3844307546	Apr 26, 2020 (154)
162	HGDP	ss3847884297	Apr 26, 2020 (154)
163	SGDP_PRJ	ss3867919723	Apr 26, 2020 (154)
164	KRGDB	ss3915196914	Apr 26, 2020 (154)
165	FSA-LAB	ss3984372930	Apr 26, 2021 (155)
166	FSA-LAB	ss3984372931	Apr 26, 2021 (155)
167	EVA	ss3985309583	Apr 26, 2021 (155)
168	EVA	ss3986040482	Apr 26, 2021 (155)
169	EVA	ss3986389465	Apr 26, 2021 (155)
170	EVA	ss4017348158	Apr 26, 2021 (155)
171	TOPMED	ss4755518339	Apr 26, 2021 (155)
172	TOMMO_GENOMICS	ss5184520701	Apr 26, 2021 (155)
173	EVA	ss5237034913	Apr 26, 2021 (155)
174	EVA	ss5237196964	Apr 26, 2021 (155)
175	EVA	ss5237649567	Oct 13, 2022 (156)
176	1000G_HIGH_COVERAGE	ss5273924025	Oct 13, 2022 (156)
177	TRAN_CS_UWATERLOO	ss5314420528	Oct 13, 2022 (156)
178	EVA	ss5315264595	Oct 13, 2022 (156)
179	EVA	ss5375308519	Oct 13, 2022 (156)
180	HUGCELL_USP	ss5470907346	Oct 13, 2022 (156)
181	EVA	ss5509053967	Oct 13, 2022 (156)
182	1000G_HIGH_COVERAGE	ss5562652407	Oct 13, 2022 (156)
183	SANFORD_IMAGENETICS	ss5624669527	Oct 13, 2022 (156)
184	SANFORD_IMAGENETICS	ss5643527652	Oct 13, 2022 (156)
185	TOMMO_GENOMICS	ss5725186451	Oct 13, 2022 (156)
186	EVA	ss5799432267	Oct 13, 2022 (156)
187	EVA	ss5799731242	Oct 13, 2022 (156)
188	EVA	ss5800140450	Oct 13, 2022 (156)
189	YY_MCH	ss5808899279	Oct 13, 2022 (156)
190	EVA	ss5823214155	Oct 13, 2022 (156)
191	EVA	ss5847322501	Oct 13, 2022 (156)
192	EVA	ss5848145710	Oct 13, 2022 (156)
193	EVA	ss5848686717	Oct 13, 2022 (156)
194	EVA	ss5856009981	Oct 13, 2022 (156)
195	EVA	ss5859967105	Oct 13, 2022 (156)
196	EVA	ss5972709734	Oct 13, 2022 (156)
197	EVA	ss5979834221	Oct 13, 2022 (156)
198	EVA	ss5980449793	Oct 13, 2022 (156)
199	EVA	ss5981244157	Oct 13, 2022 (156)
200	1000Genomes	NC_000007.13 - 94937446	Oct 12, 2018 (152)
201	1000Genomes_30x	NC_000007.14 - 95308134	Oct 13, 2022 (156)
202	The Avon Longitudinal Study of Parents and Children	NC_000007.13 - 94937446	Oct 12, 2018 (152)
203	Genome-wide autozygosity in Daghestan	NC_000007.12 - 94775382	Apr 26, 2020 (154)
204	Genetic variation in the Estonian population	NC_000007.13 - 94937446	Oct 12, 2018 (152)
205	ExAC	NC_000007.13 - 94937446	Oct 12, 2018 (152)
206	FINRISK	NC_000007.13 - 94937446	Apr 26, 2020 (154)
207	The Danish reference pan genome	NC_000007.13 - 94937446	Apr 26, 2020 (154)
208	gnomAD - Genomes	NC_000007.14 - 95308134	Apr 26, 2021 (155)
209	gnomAD - Exomes	NC_000007.13 - 94937446	Jul 13, 2019 (153)
210	Genome of the Netherlands Release 5	NC_000007.13 - 94937446	Apr 26, 2020 (154)
211	HGDP-CEPH-db Supplement 1	NC_000007.12 - 94775382	Apr 26, 2020 (154)
212	HapMap	NC_000007.14 - 95308134	Apr 26, 2020 (154)
213	KOREAN population from KRGDB	NC_000007.13 - 94937446	Apr 26, 2020 (154)
214	Medical Genome Project healthy controls from Spanish population	NC_000007.13 - 94937446	Apr 26, 2020 (154)
215	Northern Sweden	NC_000007.13 - 94937446	Jul 13, 2019 (153)
216	The PAGE Study	NC_000007.14 - 95308134	Jul 13, 2019 (153)
217	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000007.13 - 94937446	Apr 26, 2021 (155)
218	PharmGKB Aggregated	NC_000007.14 - 95308134	Apr 26, 2020 (154)
219	Qatari	NC_000007.13 - 94937446	Apr 26, 2020 (154)
220	SGDP_PRJ	NC_000007.13 - 94937446	Apr 26, 2020 (154)
221	Siberian	NC_000007.13 - 94937446	Apr 26, 2020 (154)
222	8.3KJPN	NC_000007.13 - 94937446	Apr 26, 2021 (155)
223	14KJPN	NC_000007.14 - 95308134	Oct 13, 2022 (156)
224	TopMed	NC_000007.14 - 95308134	Apr 26, 2021 (155)
225	UK 10K study - Twins	NC_000007.13 - 94937446	Oct 12, 2018 (152)
226	A Vietnamese Genetic Variation Database	NC_000007.13 - 94937446	Jul 13, 2019 (153)
227	ALFA	NC_000007.14 - 95308134	Apr 26, 2021 (155)
228	ClinVar	RCV000014739.2	Oct 12, 2018 (152)
229	ClinVar	RCV000014740.2	Oct 12, 2018 (152)
230	ClinVar	RCV000133464.2	Oct 12, 2018 (152)
231	ClinVar	RCV001618211.3	Oct 13, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs11567868	Sep 24, 2004 (123)
rs13306697	Sep 24, 2004 (123)
rs17773773	Oct 08, 2004 (123)
rs60480675	May 26, 2008 (130)
rs386603940	Aug 06, 2014 (136)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
22374308, ss3915196914	NC_000007.13:94937445:T:A	NC_000007.14:95308133:T:A	(self)
ss81402884, ss3639357667, ss3639707187	NC_000007.11:94582096:T:C	NC_000007.14:95308133:T:C	(self)
474861, 562189, ss93729745, ss112370132, ss116203131, ss162541332, ss197934610, ss279445043, ss285679181, ss293919126, ss481300812, ss491909923, ss825558716, ss1397500758, ss1594137457, ss1712972386, ss2635174600, ss3643646067, ss3847884297	NC_000007.12:94775381:T:C	NC_000007.14:95308133:T:C	(self)
38228465, 21272811, 15154483, 8896414, 50000, 8477947, 5735025, 9497295, 22374308, 287700, 8161233, 535510, 9860871, 19936703, 5330286, 42490008, 21272811, 4744583, ss223213228, ss234081981, ss241016622, ss342239743, ss481325655, ss482308219, ss485445634, ss490949017, ss491401880, ss537371502, ss560164731, ss654566924, ss778574597, ss780861423, ss783168268, ss783545874, ss784123875, ss832427755, ss833059547, ss834031654, ss974464988, ss984559359, ss1067489812, ss1074809689, ss1326218939, ss1431213383, ss1582313008, ss1584053539, ss1618737743, ss1661731776, ss1688823947, ss1711171940, ss1752701004, ss1752701005, ss1805119698, ss1917819156, ss1927818941, ss1946214555, ss1946214556, ss1959033124, ss1970764838, ss2024592586, ss2152813932, ss2626788522, ss2634634581, ss2634634582, ss2708522481, ss2736571821, ss2747863415, ss2856417529, ss2985412835, ss2986044793, ss3001657597, ss3022758147, ss3022758148, ss3023063115, ss3347738528, ss3625933189, ss3629866719, ss3629866720, ss3632540396, ss3633471034, ss3634196336, ss3635131448, ss3635131449, ss3635875947, ss3636865192, ss3637628957, ss3638711166, ss3640838740, ss3640838741, ss3641216509, ss3641514015, ss3644947651, ss3644947652, ss3646359416, ss3653292049, ss3653292050, ss3654174382, ss3669416235, ss3734876368, ss3744293239, ss3744570110, ss3745431479, ss3745431480, ss3766889126, ss3772924352, ss3772924353, ss3824292698, ss3825524316, ss3825540120, ss3825723615, ss3830707815, ss3838852563, ss3867919723, ss3915196914, ss3984372930, ss3984372931, ss3985309583, ss3986040482, ss3986389465, ss4017348158, ss5184520701, ss5315264595, ss5375308519, ss5509053967, ss5624669527, ss5643527652, ss5799432267, ss5799731242, ss5800140450, ss5823214155, ss5847322501, ss5848145710, ss5848686717, ss5972709734, ss5979834221, ss5980449793, ss5981244157	NC_000007.13:94937445:T:C	NC_000007.14:95308133:T:C	(self)
RCV000014739.2, RCV000014740.2, RCV000133464.2, RCV001618211.3, 50178342, 269750030, 3450061, 605937, 11562, 59023555, 592895898, 11491559959, ss244238655, ss256302371, ss2295963308, ss3026089160, ss3648704829, ss3720241136, ss3726463017, ss3771384468, ss3810061499, ss3844307546, ss4755518339, ss5237034913, ss5237196964, ss5237649567, ss5273924025, ss5314420528, ss5470907346, ss5562652407, ss5725186451, ss5808899279, ss5856009981, ss5859967105	NC_000007.14:95308133:T:C	NC_000007.14:95308133:T:C	(self)
ss667, ss4573, ss5111592, ss5586846, ss16338591, ss22887814, ss24194186, ss44784258, ss48403354, ss52088340, ss65728920, ss66688093, ss67479587, ss67836117, ss68074398, ss69022647, ss70876924, ss71466808, ss74820980, ss75593740, ss79228198, ss83344243, ss84167939, ss98319688, ss99307843, ss104451531, ss104796374, ss122584545, ss142695412, ss154372324, ss155213711, ss159548363, ss159715171, ss160792630, ss172162609, ss174049515, ss209091348, ss244305694	NT_007933.15:32970288:T:C	NC_000007.14:95308133:T:C	(self)
22374308, ss3915196914	NC_000007.13:94937445:T:G	NC_000007.14:95308133:T:G	(self)
11491559959	NC_000007.14:95308133:T:G	NC_000007.14:95308133:T:G	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

218 citations for rs662

PMID	Title	Author	Year	Journal
7916578	Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.	Adkins S et al.	1993	American journal of human genetics
8098250	The molecular basis of the human serum paraoxonase activity polymorphism.	Humbert R et al.	1993	Nature genetics
8675673	A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.	Serrato M et al.	1995	The Journal of clinical investigation
8770857	The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.	Antikainen M et al.	1996	The Journal of clinical investigation
9215303	Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.	Odawara M et al.	1997	The Journal of clinical endocrinology and metabolism
9385372	The Arg192 isoform of paraoxonase with low sarin-hydrolyzing activity is dominant in the Japanese.	Yamasaki Y et al.	1997	Human genetics
9443884	Paraoxonase-gene polymorphisms associated with coronary heart disease: support for the oxidative damage hypothesis?	Heinecke JW et al.	1998	American journal of human genetics
11238489	The BB-paraoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects.	Paolisso G et al.	2001	The Journal of clinical endocrinology and metabolism
11810302	Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm.	Ito T et al.	2002	Human genetics
11888590	Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip.	Cherry N et al.	2002	Lancet (London, England)
12082503	Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.	Bonafè M et al.	2002	European journal of human genetics
15241482	Paraoxonase 1 polymorphisms and survival.	Christiansen L et al.	2004	European journal of human genetics
17702780	Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis.	Cronin S et al.	2007	Journal of neurology, neurosurgery, and psychiatry
17975119	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	Shiffman D et al.	2008	Arteriosclerosis, thrombosis, and vascular biology
18034366	Lack of replication of genetic associations with human longevity.	Novelli V et al.	2008	Biogerontology
18194558	A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.	Sebastiani P et al.	2008	BMC genetics
18203168	Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts.	Boyles AL et al.	2008	American journal of medical genetics. Part A
18282109	Adaptations to climate in candidate genes for common metabolic disorders.	Hancock AM et al.	2008	PLoS genetics
18513389	New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.	Penco S et al.	2008	BMC bioinformatics
18603647	Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.	Simoni M et al.	2008	Human reproduction update
18618303	A common haplotype within the PON1 promoter region is associated with sporadic ALS.	Landers JE et al.	2008	Amyotrophic lateral sclerosis
18682580	Oxidative response gene polymorphisms and risk of adult brain tumors.	Rajaraman P et al.	2008	Neuro-oncology
18708400	Genetic polymorphisms in the Paraoxonase 1 gene and risk of ovarian epithelial carcinoma.	Lurie G et al.	2008	Cancer epidemiology, biomarkers & prevention
18779388	Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease.	Kavvoura FK et al.	2008	American journal of epidemiology
18787196	Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study.	Liao YC et al.	2008	Stroke
18936436	Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.	Chang MH et al.	2009	American journal of epidemiology
19041386	Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.	Boes E et al.	2009	Experimental gerontology
19104460	Interaction between PON1 and population density in amyotrophic lateral sclerosis.	Diekstra FP et al.	2009	Neuroreport
19131662	A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.	Wang X et al.	2009	Stroke
19263529	Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.	Zee RY et al.	2009	Clinica chimica acta; international journal of clinical chemistry
19276285	Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.	Sehl ME et al.	2009	Clinical cancer research
19321847	A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.	Wills AM et al.	2009	Neurology
19357718	Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women.	Ichikawa K et al.	2009	Kidney international
19587357	A systematic meta-analysis of genetic association studies for diabetic retinopathy.	Abhary S et al.	2009	Diabetes
19651761	The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies.	Rice NE et al.	2009	International journal of epidemiology
19736056	Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma.	Gold LS et al.	2009	Cancer epidemiology
19778663	Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.	Regieli JJ et al.	2009	Journal of the American College of Cardiology
20031584	Genetics of atherothrombotic and lacunar stroke.	Debette S et al.	2009	Circulation. Cardiovascular genetics
20056567	Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.	Searles Nielsen S et al.	2010	Environmental health perspectives
20140262	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.	Ryckman KK et al.	2010	PloS one
20227257	Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians.	Shaffer JR et al.	2011	Nutrition, metabolism, and cardiovascular diseases
20381198	Lack of association of PON polymorphisms with sporadic ALS in an Italian population.	Ricci C et al.	2011	Neurobiology of aging
20488557	Decreased serum arylesterase activity in autism spectrum disorders.	Gaita L et al.	2010	Psychiatry research
20529763	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	Howard TD et al.	2010	Environmental health perspectives
20616999	Usefulness of Mendelian randomization in observational epidemiology.	Bochud M et al.	2010	International journal of environmental research and public health
20839225	Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children.	Huen K et al.	2011	Environmental and molecular mutagenesis
20856122	Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.	Dahabreh IJ et al.	2010	Genetics in medicine
20947215	Paraoxonase-1 polymorphisms in Alzheimer's disease, Parkinson's disease, and AD-PD spectrum diseases.	Wingo TS et al.	2012	Neurobiology of aging
20980077	Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.	Erlich PM et al.	2012	Neurobiology of aging
21054877	Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994.	Ned RM et al.	2010	BMC medical genetics
21122033	Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients.	Fernandez-Cadenas I et al.	2011	European journal of neurology
21146954	Genes and abdominal aortic aneurysm.	Hinterseher I et al.	2011	Annals of vascular surgery
21170047	Paraoxonase-1 is a major determinant of clopidogrel efficacy.	Bouman HJ et al.	2011	Nature medicine
21223581	Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.	Dasgupta S et al.	2011	BMC medical genetics
21231776	C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging.	Acampa W et al.	2011	Scandinavian journal of clinical and laboratory investigation
21438666	Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.	Bhaskar S et al.	2011	Genetic testing and molecular biomarkers
21543280	Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.	Ayotte P et al.	2011	Environmental health perspectives
21567207	Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.	Masud R et al.	2011	Molecular and cellular biochemistry
21609220	Genetics of age-related macular degeneration: current concepts, future directions.	Deangelis MM et al.	2011	Seminars in ophthalmology
21629682	Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis.	Gupta N et al.	2011	PloS one
21685174	Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.	Trenk D et al.	2011	Circulation. Cardiovascular genetics
21852972	Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis.	Riedmaier S et al.	2011	Frontiers in pharmacology
21881565	Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.	Lewis JP et al.	2011	Clinical pharmacology and therapeutics
21894447	Are centenarians genetically predisposed to lower disease risk?	Ruiz JR et al.	2012	Age (Dordrecht, Netherlands)
21918509	Pharmacogenomics: application to the management of cardiovascular disease.	Johnson JA et al.	2011	Clinical pharmacology and therapeutics
21921273	Cardiovascular pharmacogenomics.	Roden DM et al.	2011	Circulation research
22133529	Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis.	Saadat M et al.	2012	Cancer epidemiology
22187169	A new PCR method: one primer amplification of PCR-CTPP products.	Yin G et al.	2012	Molecular biotechnology
22190063	Predicting clopidogrel response using DNA samples linked to an electronic health record.	Delaney JT et al.	2012	Clinical pharmacology and therapeutics
22206979	Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population.	Ji G et al.	2012	Free radical biology & medicine
22303384	Whole genome sequences of a male and female supercentenarian, ages greater than 114 years.	Sebastiani P et al.	2011	Frontiers in genetics
22328972	A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.	Lee YC et al.	2011	Journal of data mining in genomics & proteomics
22424094	Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.	Potts LF et al.	2012	BMC medical genetics
22427735	Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response.	Kreutz RP et al.	2012	Clinical pharmacology
22520065	Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis.	Reny JL et al.	2012	Journal of thrombosis and haemostasis
22553514	Single nucleotide polymorphisms of metabolic syndrome-related genes in primary open angle glaucoma.	Zhou G et al.	2010	International journal of ophthalmology
22577559	Novel associations of nonstructural Loci with paraoxonase activity.	Quillen EE et al.	2012	Journal of lipids
22615820	Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age.	Andersen HR et al.	2012	PloS one
22685667	Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease.	Kim DS et al.	2012	Journal of lipids
22723959	Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population.	Chen DY et al.	2012	PloS one
22792358	Association between genetic variants in DNA and histone methylation and telomere length.	Kim S et al.	2012	PloS one
22877234	Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Ménière's disease in a Japanese population.	Teranishi M et al.	2012	DNA and cell biology
22884547	Association analysis of PON polymorphisms in sporadic ALS in a Chinese population.	Chen Y et al.	2012	Neurobiology of aging
22938532	Sequencing and analysis of a South Asian-Indian personal genome.	Gupta R et al.	2012	BMC genomics
22976839	NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution.	de Aguiar Gonçalves BA et al.	2012	Cancer causes & control
23049851	Potential of ayurgenomics approach in complex trait research: leads from a pilot study on rheumatoid arthritis.	Juyal RC et al.	2012	PloS one
23259684	Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study.	Zhao P et al.	2012	BMC cancer
23319877	Association between ABCB1 Polymorphisms and Ischemic Stroke in Korean Population.	Kim YO et al.	2012	Experimental neurobiology
23422753	Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia.	Flanagan JM et al.	2013	Blood
23497168	Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population.	Rudkowska I et al.	2013	Nutrition & metabolism
23625196	The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects.	Hassan MA et al.	2013	Molecular and cellular biochemistry
23651475	Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study.	Conesa-Zamora P et al.	2013	BMC cancer
23697979	Pharmacogenomics of anti-platelet therapy: how much evidence is enough for clinical implementation?	Perry CG et al.	2013	Journal of human genetics
23797323	Pharmacogenomics of anti-platelet and anti-coagulation therapy.	Fisch AS et al.	2013	Current cardiology reports
23903878	Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years.	Julvez J et al.	2013	Epidemiology (Cambridge, Mass.)
23917967	Association of paraoxonase 1 gene polymorphism and enzyme activity with carotid plaque in rheumatoid arthritis.	Charles-Schoeman C et al.	2013	Arthritis and rheumatism
24100645	Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy.	Wang J et al.	2013	Molecular medicine reports
24130171	Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.	Deroo LA et al.	2014	Carcinogenesis
24448003	Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults.	Drescher O et al.	2014	Journal of exposure science & environmental epidemiology
24562334	Genetics of oxidative stress in obesity.	Rupérez AI et al.	2014	International journal of molecular sciences
24705954	Genotyping single-nucleotide polymorphisms of human genes involved in organophosphate detoxification by high-resolution melting.	Kurdyukov I et al.	2014	Analytical and bioanalytical chemistry
24833785	Investigation of a PON1 gene polymorphism (rs662 polymorphism) as predictor of subclinical atherosclerosis in patients with rheumatoid arthritis.	López-Mejías R et al.	2014	Annals of the rheumatic diseases
24895604	Antioxidant defense enzyme genes and asthma susceptibility: gender-specific effects and heterogeneity in gene-gene interactions between pathogenetic variants of the disease.	Polonikov AV et al.	2014	BioMed research international
24900975	Shared mechanisms of neurodegeneration in Alzheimer's disease and Parkinson's disease.	Xie A et al.	2014	BioMed research international
24903972	Genetic predisposition to calcific aortic stenosis and mitral annular calcification.	Kutikhin AG et al.	2014	Molecular biology reports
24918121	Association between PON1 rs662 polymorphism and coronary artery disease.	Liu T et al.	2014	European journal of clinical nutrition
24965284	Synergistic epistasis of paraoxonase 1 (rs662 and rs85460) and apolipoprotein E4 genes in pathogenesis of Alzheimer's disease and vascular dementia.	Alam R et al.	2014	American journal of Alzheimer's disease and other dementias
24972570	PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors.	Vasconcelos GM et al.	2014	Molecular biology reports
24981930	Relationships between PON1 Q192R polymorphism and clinical outcome of antiplatelet treatment after percutaneous coronary intervention: a meta-analysis.	Li P et al.	2014	Molecular biology reports
25051347	Interplay between genetic and clinical variables affecting platelet reactivity and cardiac adverse events in patients undergoing percutaneous coronary intervention.	Siller-Matula JM et al.	2014	PloS one
25097799	Developments in Ocular Genetics: 2013 Annual Review.	Aboobakar IF et al.	2014	Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
25155309	The influence of renal function on the association of rs854560 polymorphism of paraoxonase 1 gene with long-term prognosis in patients after myocardial infarction.	Szpakowicz A et al.	2016	Heart and vessels
25179377	Association between butyrylcholinesterase activity and phenotypes, paraoxonase192 rs662 gene polymorphism and their enzymatic activity with severity of rheumatoid arthritis: correlation with systemic inflammatory markers and oxidative stress, preliminary report.	Shahmohamadnejad S et al.	2015	Clinical biochemistry
25368670	CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.	Parnell LD et al.	2014	BioData mining
25545243	Oxidative stress-related genetic polymorphisms are associated with the prognosis of metastatic gastric cancer patients treated with epirubicin, oxaliplatin and 5-fluorouracil combination chemotherapy.	Geng R et al.	2014	PloS one
25746376	Interaction effects between Paraoxonase 1 variants and cigarette smoking on risk of coronary heart disease in a Singaporean Chinese population.	Han Y et al.	2015	Atherosclerosis
25897256	Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics.	Beitelshees AL et al.	2015	Pharmacogenomics and personalized medicine
25935173	Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.	Alharbi KK et al.	2015	Saudi medical journal
26079344	PON1 polymorphisms are predictors of ability to attain HDL-C goals in statin-treated patients.	de Souza JA et al.	2015	Clinical biochemistry
26091975	Paraoxonase-1 and oxidized lipoprotein lipids. The Cardiovascular Risk in Young Finns Study.	Kresanov P et al.	2015	Atherosclerosis
26114387	Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity.	Sun K et al.	2015	International journal of molecular sciences
26227792	Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.	Park HJ et al.	2015	Journal of molecular neuroscience
26322220	A comprehensive meta-analysis of common genetic variants in autism spectrum conditions.	Warrier V et al.	2015	Molecular autism
26383258	Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene-Pesticide Interactions in a Case-Control Study of Parkinson's Disease, California (USA).	Paul KC et al.	2016	Environmental health perspectives
26573179	PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes.	Mega JL et al.	2016	Journal of thrombosis and thrombolysis
26632904	Association of Paraoxonase 1 Gene Polymorphisms With the Risk of Hepatitis B Virus-related Liver Diseases in a Guangxi Population: A Case-control Study.	Lao X et al.	2015	Medicine
26648684	Update on genetics and diabetic retinopathy.	Hampton BM et al.	2015	Clinical ophthalmology (Auckland, N.Z.)
26815637	Paraoxonase 1 Activity Is Modulated by the rs662 Polymorphism and IgG Anti-High-Density Lipoprotein Antibodies in Patients With Rheumatoid Arthritis: Potential Implications for Cardiovascular Disease.	Rodríguez-Carrio J et al.	2016	Arthritis & rheumatology (Hoboken, N.J.)
26870959	Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting.	Li XQ et al.	2016	PloS one
26978533	Paraoxonase 1 and 2 gene variants and the ischemic stroke risk in Gran Canaria population: an association study and meta-analysis.	Rodríguez-Esparragón F et al.	2017	The International journal of neuroscience
27015811	Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents.	Kim KN et al.	2016	Environmental health
27019599	Association between L55M polymorphism in Paraoxonase 1 and cancer risk: a meta-analysis based on 21 studies.	Chen L et al.	2016	OncoTargets and therapy
27087156	The rs662 polymorphism of paraoxonase 1 affects the difference in the inhibition of butyrylcholinesterase activity by organophosphorus pesticides in human blood.	Nam DC et al.	2016	International journal of clinical pharmacology and therapeutics
27293416	Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia.	Seow DC et al.	2016	Dementia and geriatric cognitive disorders extra
27338244	Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study.	Rizzi F et al.	2016	Journal of translational medicine
27437086	Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences.	Eom SY et al.	2016	Toxicological research
27520507	Antibodies to paraoxonase 1 are associated with oxidant status and endothelial activation in rheumatoid arthritis.	Rodríguez-Carrio J et al.	2016	Clinical science (London, England
27730450	Candidate gene studies of diabetic retinopathy in human.	Priščáková P et al.	2016	Molecular biology reports
28027289	Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population.	Li Y et al.	2016	Medical science monitor
28290785	[Genetic Risk Factors of Macrovascular Complications in Patients With Type 2 Diabetes].	Bystrova AA et al.	2017	Kardiologiia
28315561	Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia.	Tetik Vardarlı A et al.	2017	Anatolian journal of cardiology
28514598	The communal relation of MTHFR, MTR, ACE gene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease.	Masud R et al.	2017	Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
28566152	Sonographic evaluation of atherosclerosis burden in carotid arteries of ischemic stroke patients and its relation to paraoxonase 1 and 2, MTHFR and AT1R genetic variants.	Hernández-Socorro CR et al.	2017	Journal of the neurological sciences
28577571	Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.	Paththinige CS et al.	2017	Lipids in health and disease
28662934	High triglycerides and low high-density lipoprotein cholesterol lipid profile in rheumatoid arthritis: A potential link among inflammation, oxidative status, and dysfunctional high-density lipoprotein.	Rodríguez-Carrio J et al.	2017	Journal of clinical lipidology
28822116	Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.	Misiak B et al.	2018	Molecular neurobiology
28827732	Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.	Wang J et al.	2017	Scientific reports
29035403	[Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides].	Bukowski K et al.	2018	Medycyna pracy
29044294	Serum Levels of Anti-PON1 and Anti-HDL Antibodies as Potential Biomarkers of Premature Atherosclerosis in Systemic Lupus Erythematosus.	López P et al.	2017	Thrombosis and haemostasis
29049176	Correlation of PON1 polymorphisms with ankylosing spondylitis susceptibility: A case-control study in Chinese Han population.	Xu H et al.	2017	Medicine
29049204	The genetic association between PON1 polymorphisms and osteonecrosis of femoral head: A case-control study.	Li JM et al.	2017	Medicine
29143350	DNA variants and organophosphate neurotoxicity among emerging farmers in the Western Cape of South Africa.	Glass T et al.	2018	American journal of industrial medicine
29167499	A Novel Multiplex HRM Assay to Detect Clopidogrel Resistance.	Zhang L et al.	2017	Scientific reports
29215590	Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study.	Juan J et al.	2017	International journal of molecular sciences
29254148	Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects.	Tang W et al.	2017	Oncotarget
29314660	European versus Asian differences for the associations between paraoxonase-1 genetic polymorphisms and susceptibility to type 2 diabetes mellitus.	Luo JQ et al.	2018	Journal of cellular and molecular medicine
29430251	Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia.	Siller-López F et al.	2017	Journal of toxicology
29849136	Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.	Bonàs-Guarch S et al.	2018	Nature communications
29922459	Association between Q192R polymorphism in the PON1 gene and statin responses in cardiac patients.	Abd Elgwad ER et al.	2018	Annals of medicine and surgery (2012)
29972410	Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants.	Pereira A et al.	2018	Arquivos brasileiros de cardiologia
30044465	Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene.	Idrees M et al.	2018	Genetics and molecular biology
30128909	Significant association between paraoxonase 1 rs662 polymorphism and coronary heart disease : A meta-analysis in the Chinese population.	Deng Z et al.	2020	Herz
30173430	[Correlation of the single nucleotide polymorphism rs662 of PON1 with the risk of male infertility].	Liu HH et al.	2018	Zhonghua nan ke xue = National journal of andrology
30182779	Genetic susceptibility to cerebrovascular disease: A systematic review.	Griessenauer CJ et al.	2018	Journal of cerebral blood flow and metabolism
30359673	Paraoxonase-1 genetic polymorphisms in organophosphate metabolism.	Dardiotis E et al.	2019	Toxicology
30465883	Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever.	Karakus N et al.	2019	Gene
30545386	Associations of the PON1 rs662 polymorphism with circulating oxidized low-density lipoprotein and lipid levels: a systematic review and meta-analysis.	Luo Z et al.	2018	Lipids in health and disease
30571812	Additional value of a combined genetic risk score to standard cardiovascular stratification.	Pereira A et al.	2018	Genetics and molecular biology
30588556	Functional implications of single nucleotide polymorphisms rs662 and rs854860 on the antioxidative activity of paraoxonase1 (PON1) in patients with rheumatoid arthritis.	Mucientes A et al.	2019	Clinical rheumatology
30734899	Epistasis between ADIPOQ rs1501299 and PON1 rs662 polymorphisms is potentially associated with the development of knee osteoarthritis.	Fernández-Torres J et al.	2019	Molecular biology reports
30903418	PON1 is a disease modifier gene in amyotrophic lateral sclerosis: association of the Q192R polymorphism with bulbar onset and reduced survival.	Verde F et al.	2019	Neurological sciences
31052559	Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview.	Levy D et al.	2019	Antioxidants (Basel, Switzerland)
31080207	Paraoxonase 1 gene (Q192R) polymorphism confers susceptibility to coronary artery disease in type 2 diabetes patients: Evidence from case-control studies.	Huo X et al.	2019	Drug discoveries & therapeutics
31241132	A Birth Cohort Study on the Genetic Modification of the Association of Prenatal Methylmercury With Child Cognitive Development.	Julvez J et al.	2019	American journal of epidemiology
31302193	A meta-analysis on relationship between paraoxonase 1 polymorphisms and atherosclerotic cardiovascular diseases.	Zeng Q et al.	2019	Life sciences
31379492	A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer's Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration.	Tian ML et al.	2019	Frontiers in neuroscience
31543510	Association of CYP2C19 Polymorphism with Clopidogrel Resistance in Patients with Acute Coronary Syndrome in China.	Su Q et al.	2019	Medical science monitor
31647334	Impact of oxidative stress SNPs and dietary antioxidant quality score on prostate cancer.	Pascual-Geler M et al.	2020	International journal of food sciences and nutrition
31762361	A meta-analysis of the relationship between paraoxonase 1 polymorphisms and cancer.	Liu P et al.	2019	Free radical research
32104210	Inherited lung cancer: a review.	de Alencar VTL et al.	2020	Ecancermedicalscience
32148648	The Association of Paraoxonase-1 Polymorphism with Carotid Artery Stenosis among Elderly Chinese Population.	Sun J et al.	2020	Oxidative medicine and cellular longevity
32388358	Genetic variants in xenobiotic detoxification enzymes, antioxidant defenses and hormonal pathways as biomarkers of susceptibility to prostate cancer.	Martinez-Gonzalez LJ et al.	2020	The Science of the total environment
32855040	Paraoxonase 1 gene polymorphisms concerning non-insulin-dependent diabetes mellitus nephropathy in hemodialysis patients.	Grzegorzewska AE et al.	2020	Journal of diabetes and its complications
32862511	Distribution of CYP2C19, ABCB1 and PON1 polymorphisms in Chinese Han, Hui, Uygur and Kazak patients with coronary atherosclerotic heart disease.	Ma L et al.	2020	International journal of immunogenetics
32949615	Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations.	Leonel Javeres MN et al.	2020	Environmental research
33138337	Genetic Variability in Antioxidative and Inflammatory Pathways Modifies the Risk for PCOS and Influences Metabolic Profile of the Syndrome.	Herman R et al.	2020	Metabolites
33154659	Susceptibility of PON1/PON2 Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population.	Pan Y et al.	2020	Pharmacogenomics and personalized medicine
33195260	Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors.	Martinelli M et al.	2020	Frontiers in cell and developmental biology
33218342	Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis.	Kunjantarachot A et al.	2020	Reproductive biology and endocrinology
33284416	Association between rs662 (A > G) and rs854560 (A > T) polymorphisms in PON1 gene and the susceptibility for psoriasis in mestizo population of Western Mexico.	Hernández-Collazo AA et al.	2021	Molecular biology reports
33356544	MirSNPs in clopidogrel metabolism genes predict cardiovascular disease risk: a case-control study and meta-analysis.	Sharma AR et al.	2021	Pharmacogenomics
33374313	Paraoxonase Role in Human Neurodegenerative Diseases.	Reichert CO et al.	2020	Antioxidants (Basel, Switzerland)
33425072	Genetic Variability of Antioxidative Mechanisms and Cardiotoxicity after Adjuvant Radiotherapy in HER2-Positive Breast Cancer Patients.	Marinko T et al.	2020	Disease markers
33466296	Discovering Genotype Variants in an Infant with VACTERL through Clinical Exome Sequencing: A Support for Personalized Risk Assessment and Disease Prevention.	Pelizzo G et al.	2021	Pediatric reports
33484495	Paraoxonase-1 (PON1) Status Analysis Using Non-Organophosphate Substrates.	Marsillach J et al.	2021	Current protocols
33499329	Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders.	Piras IS et al.	2021	Antioxidants (Basel, Switzerland)
33587860	Association of PON1, TNF-α and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma.	Santana ITS et al.	2021	Acta odontologica Scandinavica
33728967	PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity.	Mosca A et al.	2021	Personalized medicine
33778169	Arylesterase activity of paraoxonase 1 (PON1) on HDL(3) and HDL(2): Relationship with Q192R, C-108T, and L55M polymorphisms.	Valencia C SY et al.	2021	Biochemistry and biophysics reports
34137427	Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population.	Mendonça MI et al.	2021	Genetics and molecular biology
34276231	Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker.	Sousa JA et al.	2021	Clinical Medicine Insights. Cardiology
34357562	Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients.	Hirata TDC et al.	2021	Molecular diagnosis & therapy
34415683	Pharmacogenomic polygenic risk score for clopidogrel responsiveness among Caribbean Hispanics: A candidate gene approach.	Duconge J et al.	2021	Clinical and translational science
34434063	Genetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels.	Sirivarasai J et al.	2021	Risk management and healthcare policy
34445971	Paraoxonase 1 gene (PON1) variants concerning hepatitis C virus (HCV) spontaneous clearance in hemodialysis individuals: a case-control study.	Grzegorzewska AE et al.	2021	BMC infectious diseases
34452542	Association of PON1, LEP and LEPR Polymorphisms with Susceptibility to Breast Cancer: A Meta-Analysis.	Sayad S et al.	2021	Asian Pacific journal of cancer prevention
34593900	Paraoxonase 1 gene variants concerning cardiovascular mortality in conventional cigarette smokers and non-smokers treated with hemodialysis.	Grzegorzewska AE et al.	2021	Scientific reports
34766662	Genetic variants of PON1, GSTM1, GSTT1, and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico.	García-González I et al.	2022	American journal of human biology
34942860	Gene-Toxicant Interactions in Gulf War Illness: Differential Effects of the PON1 Genotype.	Vahey J et al.	2021	Brain sciences
34975123	The risk stratification of coronary vascular disease as linked to homocysteine, its modulating genes, genetic polymorphisms, conventional predictors, and with antihypertensive medicaments.	Masud R et al.	2021	The Chinese journal of physiology
35299679	Association of Paraoxonase 1 Gene Polymorphisms with the Risk of Breast Fibroadenoma and Breast Cancer in the Females of Guangxi, China.	Chen K et al.	2022	Journal of healthcare engineering
35326157	Genetic Variations on Redox Control in Cardiometabolic Diseases: The Role of Nrf2.	Zazueta C et al.	2022	Antioxidants (Basel, Switzerland)
35395775	Development and validation of polygenic risk scores for prediction of breast cancer and breast cancer subtypes in Chinese women.	Hou C et al.	2022	BMC cancer
35460610	Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis.	Paszek E et al.	2022	Clinical biochemistry
35572141	Polymorphisms of Cytochromes P450 and Glutathione S-Transferases Synergistically Modulate Risk for Parkinson's Disease.	Fan HH et al.	2022	Frontiers in aging neuroscience
35646794	Association Between Antioxidant Nutrients, Oxidative Stress-Related Gene Polymorphism and Skeletal Fluorosis in Guizhou, China.	Tao N et al.	2022	Frontiers in public health
35764155	Genetic variants of antioxidant enzymes and environmental exposures as molecular biomarkers associated with the risk and aggressiveness of bladder cancer.	Martin-Way D et al.	2022	The Science of the total environment
35998845	Role of Polymorphisms on the Recurrent Pregnancy Loss: A Systematic Review, Meta-analysis and Bioinformatic Analysis.	Jalilvand A et al.	2022	Gene

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dbSNP Short Genetic Variations

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Reference SNP (rs) Report

rs662