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Select item 68793191.

Structural basis for guide RNA processing and seed-dependent DNA targeting and cleavage by CRISPR-Cas12a

Daan C. Swarts, John van der Oost, Martin Jinek

Mol Cell. Author manuscript; available in PMC 2019 Nov 26.

Published in final edited form as: Mol Cell. 2017 Apr 20; 66(2): 221–233.e4. doi: 10.1016/j.molcel.2017.03.016

PMCID:: PMC6879319

Abstract Article PDF–2.6M

Select item 66097152.

Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast

Benjamin C. Buchmuller, Konrad Herbst, Matthias Meurer, Daniel Kirrmaier, Ehud Sass, Emmanuel D. Levy, Michael Knop

Nat Commun. 2019; 10: 2960. Published online 2019 Jul 4. doi: 10.1038/s41467-019-10816-7

PMCID:: PMC6609715

Abstract Article PDF–2.5M

Select item 65071193.

CRISPR Cpf1 proteins: structure, function and implications for genome editing

Fatemeh Safari, Khadijeh Zare, Manica Negahdaripour, Mazyar Barekati-Mowahed, Younes Ghasemi

Cell Biosci. 2019; 9: 36. Published online 2019 May 9. doi: 10.1186/s13578-019-0298-7

PMCID:: PMC6507119

Abstract Article PDF–1.4M

Select item 63157784.

Revolution in Gene Medicine Therapy and Genome Surgery

David J. Jiang, Christine L. Xu, Stephen H. Tsang

Genes (Basel) 2018 Dec; 9(12): 575. Published online 2018 Nov 26. doi: 10.3390/genes9120575

PMCID:: PMC6315778

Abstract Article PDF–312K

Select item 62835985.

Metabolic models and gene essentiality data reveal essential and conserved metabolism in prokaryotes

Joana C. Xavier, Kiran Raosaheb Patil, Isabel Rocha

PLoS Comput Biol. 2018 Nov; 14(11): e1006556. Published online 2018 Nov 16. doi: 10.1371/journal.pcbi.1006556

PMCID:: PMC6283598

Abstract Article PDF–3.4M

Select item 62247996.

Engineering the Direct Repeat Sequence of crRNA for Optimization of FnCpf1-Mediated Genome Editing in Human Cells

Li Lin, Xiubin He, Tianyuan Zhao, Lingkai Gu, Yeqing Liu, Xiaoyu Liu, Hongyan Liu, Fayu Yang, Mengjun Tu, Lianchao Tang, Xianglian Ge, Changbao Liu, Junzhao Zhao, Zongming Song, Jia Qu, Feng Gu

Mol Ther. 2018 Nov 7; 26(11): 2650–2657. Published online 2018 Sep 1. doi: 10.1016/j.ymthe.2018.08.021

PMCID:: PMC6224799

Abstract Article PDF–1.6M

Select item 62127827.

Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants

Eszter Tóth, Bernadett C Czene, Péter I Kulcsár, Sarah L Krausz, András Tálas, Antal Nyeste, Éva Varga, Krisztina Huszár, Nóra Weinhardt, Zoltán Ligeti, Adrienn É Borsy, Elfrieda Fodor, Ervin Welker

Nucleic Acids Res. 2018 Nov 2; 46(19): 10272–10285. Published online 2018 Sep 20. doi: 10.1093/nar/gky815

PMCID:: PMC6212782

Abstract Article PDF–6.5M

Select item 61998178.

Blossom of CRISPR technologies and applications in disease treatment

Huayi Liu, Lian Wang, Yunzi Luo

Synth Syst Biotechnol. 2018 Dec; 3(4): 217–228. Published online 2018 Oct 22. doi: 10.1016/j.synbio.2018.10.003

PMCID:: PMC6199817

Abstract Article PDF–1.0M

Select item 61993529.

In silico Analysis Suggests Common Appearance of scaRNAs in Type II Systems and Their Association With Bacterial Virulence

Jelena Guzina, Wei-Hua Chen, Tamara Stankovic, Magdalena Djordjevic, Evgeny Zdobnov, Marko Djordjevic

Front Genet. 2018; 9: 474. Published online 2018 Oct 17. doi: 10.3389/fgene.2018.00474

PMCID:: PMC6199352

Abstract Article PDF–3.0M

Select item 609807610.

Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo

Hyo Min Park, Hui Liu, Joann Wu, Anthony Chong, Vanessa Mackley, Christof Fellmann, Anirudh Rao, Fuguo Jiang, Hunghao Chu, Niren Murthy, Kunwoo Lee

Nat Commun. 2018; 9: 3313. Published online 2018 Aug 17. doi: 10.1038/s41467-018-05641-3

PMCID:: PMC6098076

Abstract Article PDF–2.0M

Select item 567951011.

Sequence-based information-theoretic features for gene essentiality prediction

Dawit Nigatu, Patrick Sobetzko, Malik Yousef, Werner Henkel

BMC Bioinformatics. 2017; 18: 473. Published online 2017 Nov 9. doi: 10.1186/s12859-017-1884-5

PMCID:: PMC5679510

Abstract Article PDF–845K

Select item 550665412.

New variants of CRISPR RNA‐guided genome editing enzymes

Jana Murovec, Žan Pirc, Bing Yang

Plant Biotechnol J. 2017 Aug; 15(8): 917–926. Published online 2017 May 9. doi: 10.1111/pbi.12736

PMCID:: PMC5506654

Abstract Article PDF–432K

Select item 538902413.

Modern Genome Editing Technologies in Huntington’s Disease Research

Tuyana B. Malankhanova, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian

J Huntingtons Dis. 2017; 6(1): 19–31. Prepublished online 2017 Jan 24. Published online 2017 Mar 28. doi: 10.3233/JHD-160222

PMCID:: PMC5389024

Abstract Article PDF–1.0M

Select item 502442314.

Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells

Eszter Tóth, Nóra Weinhardt, Petra Bencsura, Krisztina Huszár, Péter I. Kulcsár, András Tálas, Elfrieda Fodor, Ervin Welker

Biol Direct. 2016; 11: 46. Published online 2016 Sep 14. doi: 10.1186/s13062-016-0147-0

PMCID:: PMC5024423

Abstract Article PDF–1.1M

Select item 498443615.

Identification of DNA Methyltransferase Genes in Human Pathogenic Bacteria by Comparative Genomics

Aniel Jessica Leticia Brambila-Tapia, Augusto Cesar Poot-Hernández, Ernesto Perez-Rueda, Katya Rodríguez-Vázquez

Indian J Microbiol. 2016 Jun; 56(2): 134–141. Published online 2015 Dec 31. doi: 10.1007/s12088-015-0562-4

PMCID:: PMC4984436

Abstract Article PDF–502K

Select item 463822016.

Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system

Bernd Zetsche, Jonathan S. Gootenberg, Omar O. Abudayyeh, Ian M. Slaymaker, Kira S. Makarova, Patrick Essletzbichler, Sara Volz, Julia Joung, John van der Oost, Aviv Regev, Eugene V. Koonin, Feng Zhang

Cell. Author manuscript; available in PMC 2016 Oct 22.

Published in final edited form as: Cell. 2015 Oct 22; 163(3): 759–771. Published online 2015 Sep 25. doi: 10.1016/j.cell.2015.09.038

PMCID:: PMC4638220

Abstract Article PDF–1.7M

Select item 359850717.

The evolutionary rate of antibacterial drug targets

Arkadiusz Gladki, Szymon Kaczanowski, Pawel Szczesny, Piotr Zielenkiewicz

BMC Bioinformatics. 2013; 14: 36. Published online 2013 Feb 1. doi: 10.1186/1471-2105-14-36

PMCID:: PMC3598507

Abstract Article PDF–559K

Select item 305687518.

The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon

Ruben E Valas, Philip E Bourne

Biol Direct. 2011; 6: 16. Published online 2011 Feb 28. doi: 10.1186/1745-6150-6-16

PMCID:: PMC3056875

Abstract Article PDF–1.0M

Select item 282074419.

Inhibition of AcpA Phosphatase Activity with Ascorbate Attenuates Francisella tularensis Intramacrophage Survival

Steven McRae, Fernando A. Pagliai, Nrusingh P. Mohapatra, Alejandro Gener, Asma Sayed Abdelgeliel Mahmou, John S. Gunn, Graciela L. Lorca, Claudio F. Gonzalez

J Biol Chem. 2010 Feb 19; 285(8): 5171–5177. Published online 2009 Dec 22. doi: 10.1074/jbc.M109.039511