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Items: 1 to 20 of 86

1.
Alternative genomic diagnoses for individuals with a clinical diagnosis of Dubowitz syndrome
David A. Dyment, Anne O’Donnell-Luria, Pankaj B. Agrawal, Zeynep Coban Akdemir, Kyrieckos A. Aleck, Danny Antaki, Hind Al Sharhan, Ping-Yee B. Au, Hatip Aydin, Alan H. Beggs, Kaya Bilguvar, Eric Boerwinkle, Harrison Brand, Catherine A. Brownstein, Steve Buyske, Bernard Chodirker, Jungmin Choi, Albert E. Chudley, Carol L. Clericuzio, Gerald F. Cox, Cynthia Curry, Elke de Boer, Bert B.A. de Vries, Kathryn Dunn, Cullen M. Dutmer, Eleina M. England, Jill A. Fahrner, Bilgen B. Geckinli, Casie A. Genetti, Alper Gezdirici, William T. Gibson, Joseph G. Gleeson, Cheryl R. Greenberg, April Hall, Ada Hamosh, Taila Hartley, Shalini Jhangiani, Ender Karaca, Kristin Kernohan, Julie L. Lauzon, M.E. Suzanne Lewis, R. Brian Lowry, Francesc López-Giráldez, Tara C. Matise, Jennifer McEvoy-Venneri, Brenda McInnes, Aziz Mhanni, Sixto Garcia Minaur, Jukka Moilanen, An Nguyen, Malgorzata J.M. Nowaczyk, Jennifer Posey, Katrin Õunap, Davut Pehlivan, Sander Pajusalu, Lynette S. Penney, Timothy Poterba, Paolo Prontera, Maria Juliana Rodovalho Doriqui, Sarah L. Sawyer S, Nara Sobreira, Valentina Stanley, Deniz Torun, David Wargowski, P. Dane Witmer, Isaac Wong, Jinchuan Xing, Maha S. Zaki, Yeting Zhang, Care4Rare Consortium, Centers for Mendelian Genomics, Kym M. Boycott, Michael J. Bamshad, Deborah A. Nickerson, Elizabeth E. Blue, A. Micheil Innes
Am J Med Genet A. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Am J Med Genet A. 2021 Jan; 185(1): 119–133. Published online 2020 Oct 24. doi: 10.1002/ajmg.a.61926
PMCID:
PMC8197629
ArticlePDF–1.4M
2.
HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells
Soon-Duck Ha, Naomi Lewin, Shawn S. C. Li, Sung-Ouk Kim
Cells. 2021 May; 10(5): 1101. Published online 2021 May 4. doi: 10.3390/cells10051101
PMCID:
PMC8147860
ArticlePDF–3.6M
3.
Structural Analysis of Histone Deacetylase 8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders
Jeremy D. Osko, Nicholas J. Porter, Christophe Decroos, Matthew S. Lee, Paris R. Watson, Sarah E. Raible, Ian D. Krantz, Matthew A. Deardorff, David W. Christianson
J Struct Biol. Author manuscript; available in PMC 2022 Mar 1.
Published in final edited form as: J Struct Biol. 2021 Mar; 213(1): 107681. Published online 2020 Dec 11. doi: 10.1016/j.jsb.2020.107681
PMCID:
PMC7981260
ArticlePDF–2.9M
4.
Histone deacetylase 8 inhibition suppresses mantle cell lymphoma viability while preserving natural killer cell function
January M. Watters, Gabriela Wright, Matthew A. Smith, Bijal Shah, Kenneth L. Wright
Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Biochem Biophys Res Commun. 2021 Jan 1; 534: 773–779. Published online 2020 Nov 13. doi: 10.1016/j.bbrc.2020.11.001
PMCID:
PMC7785659
ArticlePDF–1.1M
5.
A distal regulatory region of a class I human histone deacetylase
Nicolas D. Werbeck, Vaibhav Kumar Shukla, Micha B. A. Kunze, Havva Yalinca, Ruth B. Pritchard, Lucas Siemons, Somnath Mondal, Simon O. R. Greenwood, John Kirkpatrick, Charles M. Marson, D. Flemming Hansen
Nat Commun. 2020; 11: 3841. Published online 2020 Jul 31. doi: 10.1038/s41467-020-17610-w
PMCID:
PMC7395746
ArticlePDF–1.4M
6.
Association of HDAC8 Expression with Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis
Mohammad-Nazir Menbari, Karim Rahimi, Abbas Ahmadi, Samira Mohammadi-Yeganeh, Anvar Elyasi, Nikoo Darvishi, Vahedeh Hosseini, Mohammad Abdi
Iran Biomed J. 2020 Sep; 24(5): 288–294. Published online 2020 May 2. doi: 10.29252/ibj.24.5.283
PMCID:
PMC7392136
ArticlePDF–891K
7.
Preparation of a New Construct of Human Histone Deacetylase 8 for the Crystallization of Enzyme-Inhibitor Complexes
Nicholas J. Porter, David W. Christianson
Methods Enzymol. Author manuscript; available in PMC 2020 Jul 18.
Published in final edited form as: Methods Enzymol. 2019; 626: 561–585. Published online 2019 Jul 18. doi: 10.1016/bs.mie.2019.06.029
PMCID:
PMC6941479
ArticlePDF–2.2M
8.
Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant
Katherine R. Welker Leng, Carol Ann Castañeda, Christophe Decroos, Barira Islam, Shozeb M. Haider, David W. Christianson, Carol A. Fierke
Biochemistry. Author manuscript; available in PMC 2020 Nov 12.
Published in final edited form as: Biochemistry. 2019 Nov 12; 58(45): 4480–4493. Published online 2019 Nov 4. doi: 10.1021/acs.biochem.9b00653
PMCID:
PMC6903415
ArticlePDF–2.5M
9.
Discovery of novel potential selective HDAC8 inhibitors by combine ligand-based, structure-based virtual screening and in-vitro biological evaluation
Sudhan Debnath, Tanusree Debnath, Samhita Bhaumik, Swapan Majumdar, Arunasree M. Kalle, Vema Aparna
Sci Rep. 2019; 9: 17174. Published online 2019 Nov 20. doi: 10.1038/s41598-019-53376-y
PMCID:
PMC6868012
ArticlePDF–2.3M
10.
HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy
Michael F. Emmons, Fernanda Faião-Flores, Ritin Sharma, Ram Thapa, Jane L. Messina, Jurgen C. Becker, Dirk Schadendorf, Edward Seto, Vernon K. Sondak, John M. Koomen, Yian A. Chen, Eric K. Lau, Lixin Wan, Jonathan D. Licht, Keiran S.M. Smalley
Cancer Res. Author manuscript; available in PMC 2020 Jun 1.
Published in final edited form as: Cancer Res. 2019 Jun 1; 79(11): 2947–2961. Published online 2019 Apr 15. doi: 10.1158/0008-5472.CAN-19-0040
PMCID:
PMC6548652
ArticlePDF–2.4M
11.
HDAC8 inhibition ameliorates pulmonary fibrosis
Shigeki Saito, Yan Zhuang, Takayoshi Suzuki, Yosuke Ota, Marjorie E. Bateman, Ala L. Alkhatib, Gilbert F. Morris, Joseph A. Lasky
Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316(1): L175–L186. Published online 2018 Oct 25. doi: 10.1152/ajplung.00551.2017
PMCID:
PMC6383499
Article
12.
HDAC8, A Potential Therapeutic Target, Regulates Proliferation and Differentiation of Bone Marrow Stromal Cells in Fibrous Dysplasia
Tao Xiao, Yu Fu, Weiwen Zhu, Rongyao Xu, Ling Xu, Ping Zhang, Yifei Du, Jie Cheng, Hongbing Jiang
Stem Cells Transl Med. 2019 Feb; 8(2): 148–161. Published online 2018 Nov 13. doi: 10.1002/sctm.18-0057
PMCID:
PMC6344909
ArticlePDF–5.7M
13.
Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity
Soon-Duck Ha, Ori Solomon, Masoud Akbari, Alp Sener, Sung Ouk Kim
Sci Rep. 2018; 8: 11332. Published online 2018 Jul 27. doi: 10.1038/s41598-018-29463-x
PMCID:
PMC6063935
ArticlePDF–2.6M
14.
Active site metal identity alters HDAC8 substrate selectivity: A potential novel regulatory mechanism
Carol Ann Castaneda, Jeffrey E. Lopez, Caleb G. Joseph, Michael D. Scholle, Milan Mrksich, Carol A. Fierke
Biochemistry. Author manuscript; available in PMC 2018 Oct 24.
Published in final edited form as: Biochemistry. 2017 Oct 24; 56(42): 5663–5670. Published online 2017 Oct 12. doi: 10.1021/acs.biochem.7b00851
PMCID:
PMC6050578
ArticlePDF–579K
15.
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6
G. R. Vanaja, Hemalatha Golaconda Ramulu, Arunasree M. Kalle
Cell Commun Signal. 2018; 16: 20. Published online 2018 May 2. doi: 10.1186/s12964-018-0231-4
PMCID:
PMC5930436
ArticlePDF–8.4M
16.
HDAC8 substrates identified by genetically-encoded active site photocrosslinking
Jeffrey E. Lopez, Sarah E. Haynes, Jaimeen D. Majmudar, Brent R. Martin, Carol A. Fierke
J Am Chem Soc. Author manuscript; available in PMC 2018 Nov 15.
Published in final edited form as: J Am Chem Soc. 2017 Nov 15; 139(45): 16222–16227. Published online 2017 Nov 1. doi: 10.1021/jacs.7b07603
PMCID:
PMC5865639
ArticlePDF–972K
17.
Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8
Nicholas J. Porter, David W. Christianson
ACS Chem Biol. Author manuscript; available in PMC 2018 Sep 15.
Published in final edited form as: ACS Chem Biol. 2017 Sep 15; 12(9): 2281–2286. Published online 2017 Aug 30. doi: 10.1021/acschembio.7b00330
PMCID:
PMC5600712
ArticlePDF–583K
18.
Structure-based Identification of HDAC8 Non-histone Substrates
Nawsad Alam, Lior Zimmerman, Noah A. Wolfson, Caleb G. Joseph, Carol A. Fierke, Ora Schueler-Furman
Structure. Author manuscript; available in PMC 2017 Sep 8.
Published in final edited form as: Structure. 2016 Mar 1; 24(3): 458–468. doi: 10.1016/j.str.2016.02.002
PMCID:
PMC5590822
ArticlePDF–760K
19.
HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?
Teresa L. Ramos, Luis Ignacio Sánchez-Abarca, Alba Redondo, Ángel Hernández-Hernández, Antonio M. Almeida, Noemí Puig, Concepción Rodríguez, Rebeca Ortega, Silvia Preciado, Ana Rico, Sandra Muntión, José Ramón González Porras, Consuelo Del Cañizo, Fermín Sánchez-Guijo
Oncotarget. 2017 Apr 25; 8(17): 28187–28202. Published online 2017 Mar 7. doi: 10.18632/oncotarget.15969
PMCID:
PMC5438642
ArticlePDF–9.4M
20.
cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells
Ji-Yeon Park, Yong-Sung Juhnn
Exp Mol Med. 2017 Feb; 49(2): e297. Published online 2017 Feb 24. doi: 10.1038/emm.2016.152
PMCID:
PMC5336561
ArticlePDF–1.7M

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