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Select item 104830381.

HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association

Saman Majeed, Lan Dang, Md Majharul Islam, Olamide Ishola, Peter P. Borbat, Steven J. Ludtke, Elka R. Georgieva

Sci Rep. 2023; 13: 14691. Published online 2023 Sep 6. doi: 10.1038/s41598-023-41873-0

PMCID:: PMC10483038

Abstract Article PDF–2.1M

Select item 102571992.

Insights into the oligomeric structure of the HIV-1 Vpu protein

Saman Majeed, Oluwatosin Adetuyi, Peter P. Borbat, Md Majharul Islam, Olamide Ishola, Bo Zhao, Elka R. Georgieva

J Struct Biol. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: J Struct Biol. 2023 Mar; 215(1): 107943. Published online 2023 Feb 14. doi: 10.1016/j.jsb.2023.107943

PMCID:: PMC10257199

Abstract Article PDF–2.7M

Select item 101348343.

A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release

Ying Lu, Wei Pang, Man-Di Zhang, Jia-Hao Song, Fan Shen, Wen-Qiang He, Yong-Tang Zheng

J Virol. 2023 Apr; 97(4): e00200-23. Published online 2023 Mar 27. doi: 10.1128/jvi.00200-23

PMCID:: PMC10134834

Abstract Article PDF–6.0M

Select item 84029094.

Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis

Nabab Khan, Jonathan D. Geiger

Viruses. 2021 Aug; 13(8): 1466. Published online 2021 Jul 27. doi: 10.3390/v13081466

PMCID:: PMC8402909

Abstract Article PDF–1.6M

Select item 71678475.

Biophysical characterization of Vpu from HIV‐1 suggests a channel‐pore dualism

T. Mehnert, A. Routh, P. J. Judge, Y. H. Lam, D. Fischer, A. Watts, W. B. Fischer

Proteins. 2008 Mar; 70(4): 1488–1497. Published online 2007 Oct 1. doi: 10.1002/prot.21642

PMCID:: PMC7167847

Abstract Article PDF–548K

Select item 59168466.

Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu

Prashant Jain, Guney Boso, Simon Langer, Stephen Soonthornvacharin, Paul D. De Jesus, Quy Nguyen, Kevin C. Olivieri, Alex J. Portillo, Sunnie M. Yoh, Lars Pache, Sumit K. Chanda

Cell Rep. Author manuscript; available in PMC 2018 Apr 25.

Published in final edited form as: Cell Rep. 2018 Feb 27; 22(9): 2493–2503. doi: 10.1016/j.celrep.2018.01.091

PMCID:: PMC5916846

Abstract Article PDF–1.9M

Select item 56857797.

FRET Analysis of the Promiscuous yet Specific Interactions of the HIV-1 Vpu Transmembrane Domain

Gregory B. Cole, Sean E. Reichheld, Simon Sharpe

Biophys J. 2017 Nov 7; 113(9): 1992–2003. Published online 2017 Nov 7. doi: 10.1016/j.bpj.2017.09.010

PMCID:: PMC5685779

Abstract Article PDF–1.1M

Select item 54280498.

Functional conservation and coherence of HIV-1 subtype A Vpu alleles

Bizhan Romani, Amirarsalan Kavyanifard, Elham Allahbakhshi

Sci Rep. 2017; 7: 87. Published online 2017 Mar 7. doi: 10.1038/s41598-017-00222-8

PMCID:: PMC5428049

Abstract Article PDF–2.3M

Select item 50772089.

Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution

Zhanglong Liu, Xi Huang, Lingna Hu, Linh Pham, Katye M. Poole, Yan Tang, Brian P. Mahon, Wenxing Tang, Kunhua Li, Nathan E. Goldfarb, Ben M. Dunn, Robert McKenna, Gail E. Fanucci

J Biol Chem. 2016 Oct 21; 291(43): 22741–22756. Published online 2016 Aug 30. doi: 10.1074/jbc.M116.747568

PMCID:: PMC5077208

Abstract Article PDF–6.4M

Select item 492627810.

Membrane protein assembly: two cytoplasmic phosphorylated serine sites of Vpu from HIV-1 affect oligomerization

Chin-Pei Chen, Meng-Han Lin, Ya-Ting Chan, Li-Chyong Chen, Che Ma, Wolfgang B. Fischer

Sci Rep. 2016; 6: 28866. Published online 2016 Jun 29. doi: 10.1038/srep28866

PMCID:: PMC4926278

Abstract Article PDF–1.7M

Select item 490479111.

HIV-1 Vpu Mediates HLA-C Downregulation

Richard Apps, Gregory Q. Del Prete, Pramita Chatterjee, Abigail Lara, Zabrina L. Brumme, Mark A. Brockman, Stuart Neil, Suzanne Pickering, Douglas K. Schneider, Alicja Piechocka-Trocha, Bruce D. Walker, Rasmi Thomas, George M. Shaw, Beatrice H. Hahn, Brandon F. Keele, Jeffrey D. Lifson, Mary Carrington

Cell Host Microbe. Author manuscript; available in PMC 2016 Jun 13.

Published in final edited form as: Cell Host Microbe. 2016 May 11; 19(5): 686–695. doi: 10.1016/j.chom.2016.04.005

PMCID:: PMC4904791

Abstract Article PDF–2.1M

Select item 462399512.

Identifying Binding Hot Spots on Protein Surfaces by Mixed-Solvent MD: HIV-1 Protease as a Test Case

Peter M.-U. Ung, Phani Ghanakota, Sarah E. Graham, Katrina W. Lexa, Heather A. Carlson

Biopolymers. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Biopolymers. 2016 Jan; 105(1): 21–34. doi: 10.1002/bip.22742

PMCID:: PMC4623995

Abstract Article PDF–3.0M

Select item 462370813.

Structural determination of Virus protein U from HIV-1 by NMR in membrane environments

Hua Zhang, Eugene C. Lin, Bibhuti B. Das, Ye Tian, Stanley J. Opella

Biochim Biophys Acta. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Biochim Biophys Acta. 2015 Nov; 1848(11 0 0): 3007–3018. Published online 2015 Sep 8. doi: 10.1016/j.bbamem.2015.09.008

PMCID:: PMC4623708

Abstract Article PDF–1.3M

Select item 446504614.

A Direct Interaction With RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro

Marc Potempa, Ellen Nalivaika, Debra Ragland, Sook-Kyung Lee, Celia A. Schiffer, Ronald Swanstrom

J Mol Biol. Author manuscript; available in PMC 2016 Jul 17.

Published in final edited form as: J Mol Biol. 2015 Jul 17; 427(14): 2360–2378. Published online 2015 May 15. doi: 10.1016/j.jmb.2015.05.007

PMCID:: PMC4465046

Abstract Article PDF–639K

Select item 440416415.

A Functional Interplay between Human Immunodeficiency Virus Type 1 Protease Residues 77 and 93 Involved in Differential Regulation of Precursor Autoprocessing and Mature Protease Activity

Christopher J. Counts, P. Shing Ho, Maureen J. Donlin, John E. Tavis, Chaoping Chen

PLoS One. 2015; 10(4): e0123561. Published online 2015 Apr 20. doi: 10.1371/journal.pone.0123561

PMCID:: PMC4404164

Abstract Article PDF–3.9M

Select item 436869616.

Modest Attenuation of HIV-1 Vpu Alleles Derived from Elite Controller Plasma

Jingyan Chen, Nadine Tibroni, Daniel Sauter, Johanna Galaski, Toshiyuki Miura, Galit Alter, Birthe Mueller, Claudia Haller, Bruce D. Walker, Frank Kirchhoff, Zabrina L. Brumme, Takamasa Ueno, Oliver T. Fackler

PLoS One. 2015; 10(3): e0120434. Published online 2015 Mar 20. doi: 10.1371/journal.pone.0120434