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Select item 98968101.

Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms

Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda

Cell Commun Signal. 2023; 21: 30. Published online 2023 Feb 3. doi: 10.1186/s12964-023-01042-2

PMCID:: PMC9896810

Article PDF–7.4M

Select item 50648492.

17p13.3 microduplication including CRK leads to overgrowth and elevated growth factors: A case report

Rohan K. Henry, Caroline Astbury, Constantine A. Stratakis, Scott E. Hickey

Eur J Med Genet. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Eur J Med Genet. 2016 Oct; 59(10): 512–516. Published online 2016 Sep 12. doi: 10.1016/j.ejmg.2016.09.006

PMCID:: PMC5064849

Article PDF–324K

Select item 49195103.

Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl

Veer S. Bhatt, Danyun Zeng, Inna Krieger, James C. Sacchettini, Jae-Hyun Cho

Biophys J. 2016 Jun 21; 110(12): 2630–2641. Published online 2016 Jun 21. doi: 10.1016/j.bpj.2016.05.008

PMCID:: PMC4919510

Article PDF–1.3M

Select item 47419664.

Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma

Sushil Kumar, Bin Lu, Updesh Dixit, Sajjad Hossain, Yongzhang Liu, Jing Li, Peter Hornbeck, Weiming Zheng, Adam G. Sowalsky, Leszek Kotula, Raymond B. Birge

Oncotarget. 2015 Nov 10; 6(35): 37792–37807. Published online 2015 Oct 12. doi: 10.18632/oncotarget.6096

PMCID:: PMC4741966

Article PDF–5.6M

Select item 47061745.

Iterative Tyrosine Phosphorylation Controls Non-canonical Domain Utilization in Crk

Ganapathy Sriram, Wojciech Jankowski, Canan Kasikara, Charles Reichman, Tamjeed Saleh, Khanh-Quynh Nguyen, Jing Li, Peter Hornbeck, Kazuya Machida, Tong Liu, Hong Li, Charalampos G. Kalodimos, Raymond B. Birge

Oncogene. Author manuscript; available in PMC 2016 Feb 6.

Published in final edited form as: Oncogene. 2015 Aug 6; 34(32): 4260–4269. Published online 2014 Nov 10. doi: 10.1038/onc.2014.361

PMCID:: PMC4706174

Article PDF–2.7M

Select item 42604296.

Contribution of Crk Adaptor Proteins to Host Cell and Bacteria Interactions

Narcisa Martinez-Quiles, Leigh Ann Feuerbacher, María Benito-León, Philip R. Hardwidge

Biomed Res Int. 2014; 2014: 372901. Published online 2014 Nov 25. doi: 10.1155/2014/372901

PMCID:: PMC4260429

Article PDF–1.2M

Select item 40079827.

Molecular Dynamics of the Proline Switch and Its Role in Crk Signaling

Junchao Xia, Ronald M. Levy

J Phys Chem B. 2014 May 1; 118(17): 4535–4545. Published online 2014 Apr 4. doi: 10.1021/jp5013297

PMCID:: PMC4007982

Article PDF–4.2M

Select item 39681588.

Crk Adaptors Negatively Regulate Actin Polymerization in Pedestals Formed by Enteropathogenic Escherichia coli (EPEC) by Binding to Tir Effector

Elvira Nieto-Pelegrin, Eugenia Meiler, José Manuel Martín-Villa, María Benito-León, Narcisa Martinez-Quiles

PLoS Pathog. 2014 Mar; 10(3): e1004022. Published online 2014 Mar 27. doi: 10.1371/journal.ppat.1004022

PMCID:: PMC3968158

Article PDF–9.8M

Select item 33559829.

The Adaptor Protein Crk Controls Activation and Inhibition of Natural Killer Cells

Dongfang Liu, Mary E. Peterson, Eric O. Long

Immunity. Author manuscript; available in PMC 2013 Apr 20.

Published in final edited form as: Immunity. 2012 Apr 20; 36(4): 600–611. Published online 2012 Mar 29. doi: 10.1016/j.immuni.2012.03.007

PMCID:: PMC3355982

Article PDF–4.7M

Select item 331110710.

Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation

G Sriram, C Reichman, A Tunceroglu, N Kaushal, T Saleh, K Machida, B Mayer, Q Ge, J Li, P Hornbeck, CG Kalodimos, RB Birge

Oncogene. Author manuscript; available in PMC 2012 Mar 23.

Published in final edited form as: Oncogene. 2011 Nov 17; 30(46): 4645–4655. Published online 2011 May 23. doi: 10.1038/onc.2011.170

PMCID:: PMC3311107

Article PDF–2.1M

Select item 221322411.

Interaction of CagA with Crk plays an important role in Helicobacter pylori–induced loss of gastric epithelial cell adhesion

Masato Suzuki, Hitomi Mimuro, Toshihiko Suzuki, Morag Park, Tadashi Yamamoto, Chihiro Sasakawa

J Exp Med. 2005 Nov 7; 202(9): 1235–1247. doi: 10.1084/jem.20051027

PMCID:: PMC2213224

Article PDF–4.1M

Select item 36459712.

Two species of human CRK cDNA encode proteins with distinct biological activities.

M Matsuda, S Tanaka, S Nagata, A Kojima, T Kurata, M Shibuya

Mol Cell Biol. 1992 Aug; 12(8): 3482–3489. doi: 10.1128/mcb.12.8.3482

PMCID:: PMC364597

Summary Page Browse PDF–2.0M

Select item 5374513.

Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.

B J Mayer, H Hanafusa

Proc Natl Acad Sci U S A. 1990 Apr; 87(7): 2638–2642. doi: 10.1073/pnas.87.7.2638

PMCID:: PMC53745

Summary Page Browse PDF–1.3M

Select item 1012022414.

Gab2 plays a carcinogenic role in ovarian cancer by regulating CrkII

Yi Yin, Li Zhang, Yong Li, Can Zhang, Aiqin He

J Ovarian Res. 2023; 16: 79. Published online 2023 Apr 21. doi: 10.1186/s13048-023-01152-y

PMCID:: PMC10120224

Article PDF–1.7M

Select item 836612815.

MicroRNA-215-5p Inhibits the Proliferation and Migration of Wilm’s Tumor Cells by Targeting CRK

Wang Li, Li Lingdi, Dang Xiqiang, Liu Jiheng, Tan Xin, Huang Qin, Li Haisha

Technol Cancer Res Treat. 2021; 20: 15330338211036523. Published online 2021 Aug 13. doi: 10.1177/15330338211036523

PMCID:: PMC8366128

Article PDF–1.9M

Select item 804541916.

Cyclophilin A Inhibitor Debio-025 Targets Crk, Reduces Metastasis, and Induces Tumor Immunogenicity in Breast Cancer

Viralkumar Davra, Tamjeed Saleh, Ke Geng, Stanley Kimani, Dhriti Mehta, Canan Kasikara, Brendan Smith, Nicholas W. Colangelo, Bryan Ciccarelli, Hong Li, Edouard I. Azzam, Charalampos G. Kalodimos, Raymond B. Birge, Sushil Kumar

Mol Cancer Res. Author manuscript; available in PMC 2021 Apr 14.

Published in final edited form as: Mol Cancer Res. 2020 Aug; 18(8): 1189–1201. Published online 2020 Apr 22. doi: 10.1158/1541-7786.MCR-19-1144

PMCID:: PMC8045419

Article PDF–2.2M

Select item 796110517.

Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity

Taeju Park, Neka Large, Tom Curran

J Biol Chem. 2021 Jan-Jun; 296: 100390. Published online 2021 Feb 6. doi: 10.1016/j.jbc.2021.100390

PMCID:: PMC7961105

Article PDF–2.9M

Select item 660981618.

Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer

Kazuhiko Yoshida, Masumi Tsuda, Ryuji Matsumoto, Shingo Semba, Lei Wang, Hirokazu Sugino, Mishie Tanino, Tsunenori Kondo, Kazunari Tanabe, Shinya Tanaka

Cancer Sci. 2019 Jul; 110(7): 2119–2132. Published online 2019 Jun 24. doi: 10.1111/cas.14080