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Select item 33552061.

Determinants of Glycemic control in Youth with Type 2 diabetes at randomization in the TODAY study

The TODAY Study Group

Pediatr Diabetes. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Pediatr Diabetes. 2012 Aug; 13(5): 377–384. Published online 2012 Feb 15. doi: 10.1111/j.1399-5448.2011.00841.x

PMCID:: PMC3355206

Abstract Article PDF–505K

Select item 112018162.

Clinical Characteristics of Offspring Born to Parents with Type 2 Diabetes Diagnosed in Youth: Observations from TODAY

Jeanie B. Tryggestad, Megan M. Kelsey, Kimberly L. Drews, Shirley Zhou, Nancy Chang, Elia Escaname, Samuel S. Gidding, Elvira Isganaitis, Siripoom McKay, Rachana Shah, Michelle Van Name

Children (Basel) 2024 Jun; 11(6): 630. Published online 2024 May 24. doi: 10.3390/children11060630

PMCID:: PMC11201816

Abstract Article PDF–254K

Select item 91209493.

ZnT8 autoantibody prevalence is low in youth with type 2 diabetes and associated with higher insulin sensitivity, lower insulin secretion, and lower disposition index

Janine Higgins, Philip Zeitler, Kimberly L. Drews, Silva Arslanian, Kenneth Copeland, Robin Goland, Georgeanna Klingensmith, Terri H. Lipman, Sherida Tollefsen, for the TODAY Study Group

J Clin Transl Endocrinol. 2022 Sep; 29: 100300. Published online 2022 May 11. doi: 10.1016/j.jcte.2022.100300

PMCID:: PMC9120949

Abstract Article PDF–414K

Select item 97549554.

Retinal Thickness and Morphology Changes on OCT in Youth with Type 2 Diabetes: Findings from the TODAY Study

Mihai Mititelu, Diane Uschner, Lindsay Doherty, Petter Bjornstad, Amitha Domalpally, Kimberly L. Drews, Rose Gubitosi-Klug, Lynne L. Levitsky, Jeong W. Pak, Neil H. White, Barbara A. Blodi

Ophthalmol Sci. 2022 Dec; 2(4): 100191. Published online 2022 Jun 28. doi: 10.1016/j.xops.2022.100191

PMCID:: PMC9754955

Abstract Article PDF–1.0M

Select item 35844165.

Self-reported dietary intake of youth with recent onset of type 2 diabetes: Results from the TODAY study

Linda Delahanty, Andrea Kriska, Sharon Edelstein, Nancy Amodei, Jennifer Chadwick, Kenneth Copeland, Bryan Galvin, Laure El ghormli, Morey Haymond, Megan Kelsey, Chad Lassiter, Kerry Milaszewski, Amy Syme, Elizabeth Mayer-Davis

J Acad Nutr Diet. Author manuscript; available in PMC 2014 Mar 1.

Published in final edited form as: J Acad Nutr Diet. 2013 Mar; 113(3): 431–439. doi: 10.1016/j.jand.2012.11.015

PMCID:: PMC3584416

Abstract Article PDF–311K

Select item 68046146.

Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors, and Relationship to Arterial Stiffness in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study

Amy S. Shah, Laure El ghormli, Mary Ellen Vajravelu, Fida Bacha, Ryan M. Farrell, Samuel S. Gidding, Lorraine E. Levitt Katz, Jeanie B. Tryggestad, Neil H. White, Elaine M. Urbina

Diabetes Care. 2019 Nov; 42(11): 2143–2150. Published online 2019 Sep 9. doi: 10.2337/dc19-0993

PMCID:: PMC6804614

Abstract Article PDF–655K

Select item 105211647.

Connecting Today: Feasibility and acceptability of a remote visiting program for people living with dementia in long-term care homes

Hannah M O’Rourke, Jennifer Swindle, Dorothy Chacinski, Fernanda Laís Fengler Dal Pizzol, Heunjung Lee, Matthias Hoben, Tammy Hopper, Katherine S McGilton, Veronique Boscart

Dementia (London) 2023 Oct; 22(7): 1321–1347. Published online 2023 Jun 21. doi: 10.1177/14713012231176858

PMCID:: PMC10521164

Abstract Article PDF–838K

Select item 77839428.

Postintervention Effects of Varying Treatment Arms on Glycemic Failure and β-Cell Function in the TODAY Trial

The TODAY Study Group

Diabetes Care. 2021 Jan; 44(1): 75–80. Published online 2020 Nov 10. doi: 10.2337/dc20-0622

PMCID:: PMC7783942

Abstract Article PDF–871K

Select item 105298779.

Plasma Neurofilament Light Chain Concentrations are Elevated in Youth-onset Type 2 Diabetes and Associate with Neuropathy

Vera Fridman, Stefan Sillau, Alanna Ritchie, Jacob Bockhorst, Christina Coughlan, Paula Araya, Joaquin M. Espinosa, Keith Smith, Ethan M. Lange, Leslie A. Lange, Laure El Ghormli, Kimberly L. Drews, Philip Zeitler, Jane EB Reusch

J Peripher Nerv Syst. Author manuscript; available in PMC 2024 Sep 1.

Published in final edited form as: J Peripher Nerv Syst. 2023 Sep; 28(3): 460–470. Published online 2023 Aug 7. doi: 10.1111/jns.12575

PMCID:: PMC10529877

Abstract Article PDF–478K

Select item 917771410.

Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study

Amy S. Shah, Samuel S. Gidding, Laure El ghormli, Jeanie B. Tryggestad, Kristen J. Nadeau, Fida Bacha, Lorraine E. Levitt Katz, Steven M. Willi, Joao Lima, Elaine M. Urbina, TODAY Study Group

J Am Soc Echocardiogr. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: J Am Soc Echocardiogr. 2022 Jun; 35(6): 620–628.e4. Published online 2022 Feb 8. doi: 10.1016/j.echo.2022.02.001

PMCID:: PMC9177714

Abstract Article PDF–360K

Select item 765471211.

Beta cell function and insulin sensitivity in obese youth with maturity onset diabetes of youth mutations vs type 2 diabetes in TODAY: Longitudinal observations and glycemic failure

Silva Arslanian, Laure El ghormli, Morey H. Haymond, Christine L. Chan, Steven D. Chernausek, Rachelle G. Gandica, Rose Gubitosi-Klug, Lynne L. Levitsky, Maggie Siska, Steven M. Willi

Pediatr Diabetes. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Pediatr Diabetes. 2020 Jun; 21(4): 575–585. Published online 2020 Mar 3. doi: 10.1111/pedi.12998

PMCID:: PMC7654712

Abstract Article PDF–1.2M

Select item 1036912512.

Effect of Early Glycemic Control in Youth-Onset Type 2 Diabetes on Longer-Term Glycemic Control and β-Cell Function: Results From the TODAY Study

TODAY Study Group

Diabetes Care. 2023 Aug; 46(8): 1507–1514. Published online 2023 Jun 28. doi: 10.2337/dc23-0560

PMCID:: PMC10369125

Abstract Article PDF–2.5M

Select item 800728213.

Effect of surgical versus medical therapy on estimated cardiovascular event risk among adolescents with type 2 diabetes and severe obesity

Justin R. Ryder, Peixin Xu, Kristen J. Nadeau, Megan M. Kelsey, Changchun Xie, Todd Jenkins, Thomas H. Inge, Petter Bjornstad

Surg Obes Relat Dis. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Surg Obes Relat Dis. 2021 Jan; 17(1): 23–33. Published online 2020 Sep 9. doi: 10.1016/j.soard.2020.09.002

PMCID:: PMC8007282

Abstract Article PDF–1.1M

Select item 692557714.

Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents With Type 2 Diabetes

Petter Bjornstad, Kara Hughan, Megan M. Kelsey, Amy S. Shah, Jane Lynch, Edward Nehus, Mark Mitsnefes, Todd Jenkins, Peixin Xu, Changchun Xie, Thomas Inge, Kristen Nadeau

Diabetes Care. 2020 Jan; 43(1): 187–195. Published online 2019 Nov 4. doi: 10.2337/dc19-0708

PMCID:: PMC6925577

Abstract Article PDF–1.3M

Select item 660995115.

Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study

Petter Bjornstad, Lori Laffel, Jane Lynch, Laure El ghormli, Ruth S. Weinstock, Sherida E. Tollefsen, Kristen J. Nadeau

Diabetes Care. 2019 Jun; 42(6): 1120–1128. Published online 2019 Apr 9. doi: 10.2337/dc18-2147

PMCID:: PMC6609951

Abstract Article PDF–887K

Select item 574801416.

Adherence to a lifestyle program for youth with type 2 diabetes and its association with treatment outcome in the TODAY clinical trial

Robert I Berkowitz, Marsha D Marcus, Barbara J Anderson, Linda Delahanty, Nisha Grover, Andrea Kriska, Lori Laffel, Amy Syme, Elizabeth Venditti, Dorothy J. Van Buren, Denise E. Wilfley, Patrice Yasuda, Kathryn Hirst

Pediatr Diabetes. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Pediatr Diabetes. 2018 Mar; 19(2): 191–198. Published online 2017 Jun 30. doi: 10.1111/pedi.12555

PMCID:: PMC5748014

Abstract Article PDF–426K

Select item 648911717.

Self-Monitoring of Blood Glucose in Youth-Onset Type 2 Diabetes: Results From the TODAY Study

Ruth S. Weinstock, Barbara H. Braffett, Paul McGuigan, Mary E. Larkin, Nisha B. Grover, Natalie Walders-Abramson, Lori M. Laffel, Christine L. Chan, Nancy Chang, Beth E. Schwartzman, Rose Ann Barajas, Nicole Celona-Jacobs, Morey W. Haymond

Diabetes Care. 2019 May; 42(5): 903–909. Published online 2019 Mar 4. doi: 10.2337/dc18-1854

PMCID:: PMC6489117

Abstract Article PDF–750K

Select item 644435518.

Prevalence of arterial stiffness in adolescents with type 2 diabetes in the TODAY cohort: Relationships to glycemic control and other risk factors

Amy S. Shah, Laure El ghormli, Samuel S. Gidding, Fida Bacha, Kristen J. Nadeau, Lorraine E. Levitt Katz, Jeanie B. Tryggestad, Natasha Leibel, Daniel E. Hale, Elaine M. Urbina

J Diabetes Complications. Author manuscript; available in PMC 2019 Apr 2.

Published in final edited form as: J Diabetes Complications. 2018 Aug; 32(8): 740–745. Published online 2018 May 25. doi: 10.1016/j.jdiacomp.2018.05.013

PMCID:: PMC6444355

Abstract Article PDF–169K

Select item 820159819.

Adherence to multiple medications in the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) cohort: effect of additional medications on adherence to primary diabetes medication

Rachana Shah, Siripoom V. McKay, Lorraine E. Levitt Katz, Laure El ghormli, Barbara J. Anderson, Terri L. Casey, Laurie Higgins, Roberto Izquierdo, Aimee D. Wauters, Nancy Chang, TODAY Study Group

J Pediatr Endocrinol Metab. Author manuscript; available in PMC 2021 Jun 14.

Published in final edited form as: J Pediatr Endocrinol Metab. 2020 Feb 25; 33(2): 191–198. doi: 10.1515/jpem-2019-0315

PMCID:: PMC8201598

Abstract Article PDF–660K

Select item 679922820.

To end disease tomorrow, begin with trials today: Digital strategies for increased awareness of a clinical trials finder

Rebecca N. Jerome, Leah Dunkel, Nan Kennedy, Erik J. Olson, Jill M. Pulley, Gordon Bernard, Consuelo H. Wilkins, Paul A. Harris

J Clin Transl Sci. 2019 Aug; 3(4): 190–198. Published online 2019 Aug 20. doi: 10.1017/cts.2019.404

PMCID:: PMC6799228

Abstract Article PDF–703K

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Figure 3

Computation of the IRRSS score. Respiratory symptom weights were computed via factor analysis with polychoric correlation matrix of symptoms. The final IRRSS was computed as: IRRSS = 0.07 × Severe runny nose today − 0.25 × Mild runny nose today + 0.08 × Fever >100°F today − 0.17 × Sick >4 days + 0.87 × Breathing fast today + 0.82 × Retractions today + 0.91 + Wheeze Today + 0.34 × Hoarse today + 0.71 × Severe cough today − 0.08 × Moderate cough today − 0.37 × Mild cough today + 10.

Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants

J Pediatr. 2019 Nov;214:12-19.e3.
Figure 4

Graft survival in Australia and New Zealand from the 1960s to today. Short-term, medium-term and long-term graft survival in Australia and New Zealand from the 1960s to today. Reproduced with permission from [].

What are the key challenges we face in kidney transplantation today?

Transplant Res. 2013;2(Suppl 1):S1-S1.
Figure 1

TODAY organizational structure elements involved in the design and implementation of the TODAY Lifestyle Program (TLP).

Structure to utilize interventionists’ implementation experiences of a family-based behavioral weight management program to enhance the dissemination of the standardized intervention: The TODAY study

Clin Trials. ;14(4):406-412.
Figure 1

TODAY and TODAY2 flow diagram.

Postintervention Effects of Varying Treatment Arms on Glycemic Failure and β-Cell Function in the TODAY Trial

Diabetes Care. 2021 Jan;44(1):75-80.