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Select item 59165481.

A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library

Adam S. Adler, Daniel Bedinger, Matthew S. Adams, Michael A. Asensio, Robert C. Edgar, Renee Leong, Jackson Leong, Rena A. Mizrahi, Matthew J. Spindler, Srinivasa Rao Bandi, Haichun Huang, Pallavi Tawde, Peter Brams, David S. Johnson

MAbs. 2018 Apr; 10(3): 431–443. Published online 2018 Feb 1. doi: 10.1080/19420862.2018.1426422

PMCID:: PMC5916548

Abstract Article PDF–1.2M

Select item 111170522.

Improving antibody language models with native pairing

Sarah M. Burbach, Bryan Briney

Patterns (N Y) 2024 May 10; 5(5): 100967. Published online 2024 Apr 4. doi: 10.1016/j.patter.2024.100967

PMCID:: PMC11117052

Abstract Article PDF–3.8M

Select item 58718693.

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope

Christopher O. Barnes, Harry B. Gristick, Natalia T. Freund, Amelia Escolano, Artem Y. Lyubimov, Harald Hartweger, Anthony P. West, Jr., Aina E. Cohen, Michel C. Nussenzweig, Pamela J. Bjorkman

Nat Commun. 2018; 9: 1251. Published online 2018 Mar 28. doi: 10.1038/s41467-018-03632-y

PMCID:: PMC5871869

Abstract Article PDF–3.0M

Select item 101923754.

Cell activation-based screening of natively paired human T cell receptor repertoires

Ahmed S. Fahad, Cheng Yu Chung, Sheila N. López Acevedo, Nicoleen Boyle, Bharat Madan, Matías F. Gutiérrez-González, Rodrigo Matus-Nicodemos, Amy D. Laflin, Rukmini R. Ladi, John Zhou, Jacy Wolfe, Sian Llewellyn-Lacey, Richard A. Koup, Daniel C. Douek, Henry H. Balfour, Jr., David A. Price, Brandon J. DeKosky

Sci Rep. 2023; 13: 8011. Published online 2023 May 17. doi: 10.1038/s41598-023-31858-4

PMCID:: PMC10192375

Abstract Article PDF–4.6M

Select item 113837115.

Rapid synthesis and screening of natively paired antibodies against influenza hemagglutinin stem via oPool⁺ display

Wenhao O. Ouyang, Huibin Lv, Wenkan Liu, Zongjun Mou, Ruipeng Lei, Tossapol Pholcharee, Yiquan Wang, Katrine E. Dailey, Akshita B. Gopal, Danbi Choi, Madison R. Ardagh, Logan Talmage, Lucia A. Rodriguez, Xinghong Dai, Nicholas C. Wu

Version 2. bioRxiv. Preprint. 2024 Aug 31. doi: 10.1101/2024.08.30.610421

PMCID:: PMC11383711

Abstract Article PDF–5.3M

Select item 27197836.

Amyloidogenesis of Natively Unfolded Proteins

Vladimir N. Uversky

Curr Alzheimer Res. Author manuscript; available in PMC 2009 Aug 3.

Published in final edited form as: Curr Alzheimer Res. 2008 Jun; 5(3): 260–287. doi: 10.2174/156720508784533312

PMCID:: PMC2719783

Abstract Article PDF–888K

Select item 72243367.

Massively parallel interrogation and mining of natively paired human TCRαβ repertoires

Matthew J. Spindler, Ayla L. Nelson, Ellen K. Wagner, Natasha Oppermans, John S. Bridgeman, James M. Heather, Adam S. Adler, Michael A. Asensio, Robert C. Edgar, Yoong Wearn Lim, Everett H. Meyer, Robert E. Hawkins, Mark Cobbold, David S. Johnson

Nat Biotechnol. Author manuscript; available in PMC 2020 Sep 16.

Published in final edited form as: Nat Biotechnol. 2020 May; 38(5): 609–619. Published online 2020 Mar 16. doi: 10.1038/s41587-020-0438-y

PMCID:: PMC7224336

Abstract Article PDF–2.6M

Select item 19248758.

Natively Unstructured Loops Differ from Other Loops

Avner Schlessinger, Jinfeng Liu, Burkhard Rost

PLoS Comput Biol. 2007 Jul; 3(7): e140. Prepublished online 2007 Jun 5. Published online 2007 Jul 20. doi: 10.1371/journal.pcbi.0030140

PMCID:: PMC1924875

Abstract Article PDF–582K

Select item 61040269.

A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes

Diletta Ami, Paolo Mereghetti, Manuela Leri, Sofia Giorgetti, Antonino Natalello, Silvia Maria Doglia, Massimo Stefani, Monica Bucciantini

Sci Rep. 2018; 8: 12508. Published online 2018 Aug 21. doi: 10.1038/s41598-018-30995-5

PMCID:: PMC6104026

Abstract Article PDF–3.1M

Select item 612371010.

Recombinant human B cell repertoires enable screening for rare, specific, and natively paired antibodies

Saravanan Rajan, Michael R. Kierny, Andrew Mercer, Jincheng Wu, Andrey Tovchigrechko, Herren Wu, William F. Dall′Acqua, Xiaodong Xiao, Partha S. Chowdhury

Commun Biol. 2018; 1: 5. Published online 2018 Jan 22. doi: 10.1038/s42003-017-0006-2

PMCID:: PMC6123710

Abstract Article PDF–931K

Select item 580111511.

Functional Interrogation and Mining of Natively-Paired Human V_H:V_L Antibody Repertoires

Bo Wang, Brandon J. DeKosky, Morgan R. Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, Jonathan R. McDaniel, George Delidakis, Kendra E. Leigh, Thomas Niezold, Chang W. Choi, Elise G. Viox, Ahmed Fahad, Alberto Cagigi, Aurélie Ploquin, Kwanyee Leung, Eun S. Yang, Wing-Pui Kong, William N. Voss, Aaron G. Schmidt, M. Anthony Moody, David R. Ambrozak, Amy R. Henry, Farida Laboune, Julie E. Ledgerwood, Barney S. Graham, Mark Connors, Daniel C. Douek, Nancy J. Sullivan, Andrew D. Ellington, John R. Mascola, George Georgiou

Nat Biotechnol. Author manuscript; available in PMC 2018 Jul 8.

Published in final edited form as: Nat Biotechnol. 2018 Feb; 36(2): 152–155. Published online 2018 Jan 8. doi: 10.1038/nbt.4052

PMCID:: PMC5801115

Abstract Article PDF–1.1M

Select item 237352812.

Natively unfolded proteins: A point where biology waits for physics

Vladimir N. Uversky

Protein Sci. 2002 Apr; 11(4): 739–756. doi: 10.1110/ps.4210102

PMCID:: PMC2373528

Abstract Article PDF–1.1M

Select item 247566813.

Intramolecular Cohesion of Coils Mediated by Phenylalanine–Glycine Motifs in the Natively Unfolded Domain of a Nucleoporin

V. V. Krishnan, Edmond Y. Lau, Justin Yamada, Daniel P. Denning, Samir S. Patel, Michael E. Colvin, Michael F. Rexach

PLoS Comput Biol. 2008 Aug; 4(8): e1000145. Published online 2008 Aug 8. doi: 10.1371/journal.pcbi.1000145

PMCID:: PMC2475668

Abstract Article PDF–526K

Select item 232393214.

The inactivating factor of glutamine synthetase, IF7, is a "natively unfolded" protein

M. Isabel Muro-Pastor, Francisco N. Barrera, José C. Reyes, Francisco J. Florencio, José L. Neira

Protein Sci. 2003 Jul; 12(7): 1443–1454. doi: 10.1110/ps.0303203

PMCID:: PMC2323932

Abstract Article PDF–164K

Select item 842943815.

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

Zhiqiang Hou, Pawel M. Wydorski, Valerie A. Perez, Aydé Mendoza-Oliva, Bryan D. Ryder, Hilda Mirbaha, Omar Kashmer, Lukasz A. Joachimiak

Nat Commun. 2021; 12: 5338. Published online 2021 Sep 9. doi: 10.1038/s41467-021-25635-y

PMCID:: PMC8429438

Abstract Article PDF–5.3M

Select item 1042787616.

Heterologous expression, purification and structural features of native Dictyostelium discoideum dye-decolorizing peroxidase bound to a natively incorporated heme

Özlem Kalkan, Sravya Kantamneni, Lea Brings, Huijong Han, Richard Bean, Adrian P. Mancuso, Faisal H. M. Koua

Front Chem. 2023; 11: 1220543. Published online 2023 Aug 1. doi: 10.3389/fchem.2023.1220543

PMCID:: PMC10427876

Abstract Article PDF–2.2M

Select item 900505317.

Immortalization and functional screening of natively paired human T cell receptor repertoires

Ahmed S Fahad, Cheng-Yu Chung, Sheila N Lopez Acevedo, Nicoleen Boyle, Bharat Madan, Matias F Gutiérrez-González, Rodrigo Matus-Nicodemos, Amy D Laflin, Rukmini R Ladi, John Zhou, Jacy Wolfe, Sian Llewellyn-Lacey, Richard A Koup, Daniel C Douek, Henry H Balfour Jr, David A Price, Brandon J DeKosky

Protein Eng Des Sel. 2022; 35: gzab034. Published online 2022 Feb 17. doi: 10.1093/protein/gzab034

PMCID:: PMC9005053

Abstract Article PDF–1.8M

Select item 795982618.

Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients

Ahmed S. Fahad, Morgan R. Timm, Bharat Madan, Katherine E. Burgomaster, Kimberly A. Dowd, Erica Normandin, Matías F. Gutiérrez-González, Joseph M. Pennington, Matheus Oliveira De Souza, Amy R. Henry, Farida Laboune, Lingshu Wang, David R. Ambrozak, Ingelise J. Gordon, Daniel C. Douek, Julie E. Ledgerwood, Barney S. Graham, Leda R. Castilho, Theodore C. Pierson, John R. Mascola, Brandon J. DeKosky

Front Immunol. 2021; 12: 615102. Published online 2021 Feb 24. doi: 10.3389/fimmu.2021.615102

PMCID:: PMC7959826

Abstract Article PDF–3.4M

Select item 287769019.

Predictors of natively unfolded proteins: unanimous consensus score to detect a twilight zone between order and disorder in generic datasets

Antonio Deiana, Andrea Giansanti

BMC Bioinformatics. 2010; 11: 198. Published online 2010 Apr 21. doi: 10.1186/1471-2105-11-198

PMCID:: PMC2877690

Abstract Article PDF–1.1M

Select item 575888320.

Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes

Heather A Bruce, Dijun Du, Dijana Matak-Vinkovic, Katarzyna J Bandyra, R William Broadhurst, Esther Martin, Frank Sobott, Alexander V Shkumatov, Ben F Luisi

Nucleic Acids Res. 2018 Jan 9; 46(1): 387–402. Published online 2017 Nov 9. doi: 10.1093/nar/gkx1083

PMCID:: PMC5758883

Abstract Article PDF–5.8M

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natively (22810)
PMC
JGI_CABK2831.rev NIH_XGC_tropSpl1 Xenopus tropicalis cDNA clone IMAGE:7878733 3'...
JGI_CABK2831.rev NIH_XGC_tropSpl1 Xenopus tropicalis cDNA clone IMAGE:7878733 3', mRNA sequence
gi|73830775|gnl|dbEST|31081203|gb|D 95.1|

Nucleotide
NISC_no08a03.y1 NICHD_XGC_Emb8 Xenopus tropicalis cDNA clone IMAGE:5380133 5', m...
NISC_no08a03.y1 NICHD_XGC_Emb8 Xenopus tropicalis cDNA clone IMAGE:5380133 5', mRNA sequence
gi|21383812|gnl|dbEST|12636238|gb|B 43.1|

Nucleotide
dab62f08.y1 NICHD_XGC_Emb4 Xenopus laevis cDNA clone IMAGE:4201862 5' similar to...
dab62f08.y1 NICHD_XGC_Emb4 Xenopus laevis cDNA clone IMAGE:4201862 5' similar to SW:ACTB_HUMAN P02570 ACTIN, CYTOPLASMIC 1, mRNA sequence
gi|12748521|gnl|dbEST|7839243|gb|BG 4.1|

Nucleotide
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