PMC

(A) Initial cross entropy loss values of all samples with labels between 0–9 inclusive. (B) Initial cross entropy loss values of all samples with labels between 50–59. (C) Initial cross entropy loss values of all samples with labels between 90–99.

A cross entropy test provides a robust statistical test for t-SNE comparison
The MUS flow cytometry dataset was used to test the sensitivity of the cross entropy test.
(A) Three technical replicates of a single splenocyte sample were plotted on a t-SNE with FlowSOM clustering in overlay. p values for cross entropy testing are shown.
(B) t-SNE plots of splenocytes from three individual age-/sex-matched mice (biological replicates). p values for cross entropy testing are shown.
(C) t-SNE plots from lymph nodes, spleen, and tissue (small intestinal lamina propria). p values for cross entropy testing are shown.
(D) Two independent t-SNE runs of lymph node cells. p values for cross entropy testing are shown.
(E) Cumulative distribution function of p values obtained from 200 comparisons of independent t-SNE runs of the same lymph node sample. Statistical comparison with uniform distribution using KS test.
See also .

Segmented results of SKIMAN image: (a) original image; (b) 1D Fisher; (c) 1D cross entropy; (d) 1D maximum entropy; (e) 1D Tsallis entropy; (f) fuzzy entropy; (g) 2D Fisher; (h) 2D cross entropy; (i) 2D maximum entropy; (j) proposed method.

Segmented results of AIRPORT image: (a) original image; (b) 1D Fisher; (c) 1D cross entropy; (d) 1D maximum entropy; (e) 1D Tsallis entropy; (f) fuzzy entropy; (g) 2D Fisher; (h) 2D cross entropy; (i) 2D maximum entropy; (j) proposed method.