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Select item 58298221.

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

Sabrina Absalon, Karin Blomqvist, Rachel M. Rudlaff, Travis J. DeLano, Michael P. Pollastri, Jeffrey D. Dvorin

mBio. 2018 Jan-Feb; 9(1): e00130-18. Published online 2018 Feb 27. doi: 10.1128/mBio.00130-18

PMCID:: PMC5829822

Abstract Article PDF–2.5M

Select item 69522082.

Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome

Karin Blomqvist, Michaela Helmel, Chengqi Wang, Sabrina Absalon, Tetanya Labunska, Rachel M. Rudlaff, Swamy Adapa, Rays Jiang, Hanno Steen, Jeffrey D. Dvorin

mSphere. 2020 Jan-Feb; 5(1): e00921-19. Published online 2020 Jan 8. doi: 10.1128/mSphere.00921-19

PMCID:: PMC6952208

Abstract Article PDF–1.5M

Select item 31090833.

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress From Erythrocytes

Jeffrey D. Dvorin, Derek C. Martyn, Saurabh D. Patel, Joshua S. Grimley, Christine R. Collins, Christine S. Hopp, A. Taylor Bright, Scott Westenberger, Elizabeth Winzeler, Michael J. Blackman, David A. Baker, Thomas J. Wandless, Manoj T. Duraisingh

Science. Author manuscript; available in PMC 2011 Jun 6.

Published in final edited form as: Science. 2010 May 14; 328(5980): 910–912. doi: 10.1126/science.1188191

PMCID:: PMC3109083

Abstract Article PDF–573K

Select item 42633214.

Pyrazoleamide compounds are potent antimalarials that target Na⁺ homeostasis in intraerythrocytic Plasmodium falciparum

Akhil B. Vaidya, Joanne M. Morrisey, Zhongsheng Zhang, Sudipta Das, Thomas M. Daly, Thomas D. Otto, Natalie J. Spillman, Matthew Wyvratt, Peter Siegl, Jutta Marfurt, Grennady Wirjanata, Boni F. Sebayang, Ric N. Price, Arnab Chatterjee, Advait Nagle, Marcin Stasiak, Susan A. Charman, Iñigo Angulo-Barturen, Santiago Ferrer, María Belén Jiménez-Díaz, María Santos Martínez, Francisco Javier Gamo, Vicky M. Avery, Andrea Ruecker, Michael Delves, Kiaran Kirk, Matthew Berriman, Sandhya Kortagere, Jeremy Burrows, Erkang Fan, Lawrence W. Bergman

Nat Commun. 2014 Nov 25; 5: 5521. Published online 2014 Nov 25. doi: 10.1038/ncomms6521

PMCID:: PMC4263321

Abstract Article PDF–1.3M

Select item 51426245.

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

Abhisheka Bansal, Kayode K. Ojo, Jianbing Mu, Dustin J. Maly, Wesley C. Van Voorhis, Louis H. Miller

mBio. 2016 Nov-Dec; 7(6): e02011-16. Published online 2016 Dec 6. doi: 10.1128/mBio.02011-16

PMCID:: PMC5142624

Abstract Article PDF–1.7M

Select item 45596066.

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

Natalie Jane Spillman, Kiaran Kirk

Int J Parasitol Drugs Drug Resist. 2015 Dec; 5(3): 149–162. Published online 2015 Aug 27. doi: 10.1016/j.ijpddr.2015.07.001

PMCID:: PMC4559606

Abstract Article PDF–1.4M

Select item 50968297.

Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria

Julio Gallego-Delgado, Upal Basu-Roy, Maureen Ty, Matilde Alique, Cristina Fernandez-Arias, Alexandru Movila, Pollyanna Gomes, Ada Weinstock, Wenyue Xu, Innocent Edagha, Samuel C. Wassmer, Thomas Walther, Marta Ruiz-Ortega, Ana Rodriguez

J Clin Invest. 2016 Oct 3; 126(10): 4016–4029. Published online 2016 Sep 19. doi: 10.1172/JCI87306

PMCID:: PMC5096829

Abstract Article PDF–4.0M

Select item 81871638.

Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum

Jenna Oberstaller, Linda Zoungrana, Carl D. Bannerman, Samira Jahangiri, Ankit Dwivedi, Joana C. Silva, John H. Adams, Shannon Takala-Harrison

Int J Parasitol Drugs Drug Resist. 2021 Aug; 16: 119–128. Published online 2021 May 26. doi: 10.1016/j.ijpddr.2021.05.006

PMCID:: PMC8187163

Abstract Article PDF–2.3M

Select item 76644279.

An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors

Chantalle Moolman, Rencia van der Sluis, Richard M. Beteck, Lesetja J. Legoabe

Molecules. 2020 Nov; 25(21): 5182. Published online 2020 Nov 7. doi: 10.3390/molecules25215182

PMCID:: PMC7664427

Abstract Article PDF–4.5M

Select item 845313710.

CDPKs: The critical decoders of calcium signal at various stages of malaria parasite development

Manish Sharma, Himashree Choudhury, Rajarshi Roy, Samantha A. Michaels, Kayode K. Ojo, Abhisheka Bansal

Comput Struct Biotechnol J. 2021; 19: 5092–5107. Published online 2021 Sep 6. doi: 10.1016/j.csbj.2021.08.054

PMCID:: PMC8453137

Abstract Article PDF–3.0M

Select item 322772511.

The Cryptosporidium parvum Kinome

Jennifer D Artz, Amy K Wernimont, Abdellah Allali-Hassani, Yong Zhao, Mehrnaz Amani, Yu-Hui Lin, Guillermo Senisterra, Gregory A Wasney, Oleg Fedorov, Oliver King, Annette Roos, Vlad V Lunin, Wei Qiu, Patrick Finerty, Jr, Ashley Hutchinson, Irene Chau, Frank von Delft, Farrell MacKenzie, Jocelyne Lew, Ivona Kozieradzki, Masoud Vedadi, Matthieu Schapira, Chao Zhang, Kevan Shokat, Tom Heightman, Raymond Hui

BMC Genomics. 2011; 12: 478. Published online 2011 Sep 30. doi: 10.1186/1471-2164-12-478

PMCID:: PMC3227725

Abstract Article PDF–2.1M

Select item 434035112.

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

Erika L. Flannery, Case W. McNamara, Sang Wan Kim, Tomoyo Sakata Kato, Fengwu Li, Christine H. Teng, Kerstin Gagaring, Micah J. Manary, Rachel Barboa, Stephan Meister, Kelli Kuhen, Joseph M. Vinetz, Arnab K. Chatterjee, Elizabeth A. Winzeler

ACS Chem Biol. 2015 Feb 20; 10(2): 413–420. Published online 2014 Oct 16. doi: 10.1021/cb500616x

PMCID:: PMC4340351

Abstract Article PDF–2.2M

Select item 652249213.

An essential contractile ring protein controls cell division in Plasmodium falciparum

Rachel M. Rudlaff, Stephan Kraemer, Vincent A. Streva, Jeffrey D. Dvorin

Nat Commun. 2019; 10: 2181. Published online 2019 May 16. doi: 10.1038/s41467-019-10214-z

PMCID:: PMC6522492

Abstract Article PDF–7.2M

Select item 835582414.

Calcium in the Backstage of Malaria Parasite Biology

Lucas Silva de Oliveira, Marcos Rodrigo Alborghetti, Renata Garcia Carneiro, Izabela Marques Dourado Bastos, Rogerio Amino, Philippe Grellier, Sébastien Charneau

Front Cell Infect Microbiol. 2021; 11: 708834. Published online 2021 Jul 28. doi: 10.3389/fcimb.2021.708834

PMCID:: PMC8355824

Abstract Article PDF–839K

Select item 536868515.

Signaling Strategies of Malaria Parasite for Its Survival, Proliferation, and Infection during Erythrocytic Stage

Rani Soni, Drista Sharma, Praveen Rai, Bhaskar Sharma, Tarun K. Bhatt

Front Immunol. 2017; 8: 349. Published online 2017 Mar 28. doi: 10.3389/fimmu.2017.00349

PMCID:: PMC5368685

Abstract Article PDF–1.1M

Select item 744423616.

Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection

George Ghartey-Kwansah, Qinan Yin, Zhongguang Li, Kristyn Gumpper, Yuting Sun, Rong Yang, Dan Wang, Odell Jones, Xin Zhou, Liyang Wang, Joseph Bryant, Jianjie Ma, Johnson Nyarko Boampong, Xuehong Xu

Cell Transplant. 2020 Jan-Dec; 29: 0963689719884888. Published online 2020 Mar 17. doi: 10.1177/0963689719884888

PMCID:: PMC7444236

Abstract Article PDF–440K

Select item 856138417.

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

Sudhir Kumar, Meseret T. Haile, Michael R. Hoopmann, Linh T. Tran, Samantha A. Michaels, Seamus R. Morrone, Kayode K. Ojo, Laura M. Reynolds, Ulrike Kusebauch, Ashley M. Vaughan, Robert L. Moritz, Stefan H. I. Kappe, Kristian E. Swearingen

mBio. 2021 Nov-Dec; 12(6): e02575-21. Published online 2021 Nov 2. doi: 10.1128/mBio.02575-21

PMCID:: PMC8561384

Abstract Article PDF–3.4M

Select item 799034218.

Ca²⁺ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

Aurélia C. Balestra, Konstantinos Koussis, Natacha Klages, Steven A. Howell, Helen R. Flynn, Marcus Bantscheff, Carla Pasquarello, Abigail J. Perrin, Lorenzo Brusini, Patrizia Arboit, Olalla Sanz, Laura Peces-Barba Castaño, Chrislaine Withers-Martinez, Alexandre Hainard, Sonja Ghidelli-Disse, Ambrosius P. Snijders, David A. Baker, Michael J. Blackman, Mathieu Brochet

Sci Adv. 2021 Mar; 7(13): eabe5396. Published online 2021 Mar 24. doi: 10.1126/sciadv.abe5396

PMCID:: PMC7990342

Abstract Article PDF–3.4M

Select item 450702119.

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Mahmood M. Alam, Lev Solyakov, Andrew R. Bottrill, Christian Flueck, Faiza A. Siddiqui, Shailja Singh, Sharad Mistry, Maria Viskaduraki, Kate Lee, Christine S. Hopp, Chetan E. Chitnis, Christian Doerig, Robert W. Moon, Judith L. Green, Anthony A. Holder, David A. Baker, Andrew B. Tobin

Nat Commun. 2015; 6: 7285. Published online 2015 Jul 7. doi: 10.1038/ncomms8285

PMCID:: PMC4507021

Abstract Article PDF–2.2M

Select item 323984320.

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

Eric Talevich, Amar Mirza, Natarajan Kannan

BMC Evol Biol. 2011; 11: 321. Published online 2011 Nov 2. doi: 10.1186/1471-2148-11-321

PMCID:: PMC3239843

Abstract Article PDF–9.3M

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PF3D7_1337800 OR PF13_0211 OR "plasmodium falciparum CDPK5" OR "P... (87)
PF3D7_1337800 OR PF13_0211 OR "plasmodium falciparum CDPK5" OR "PfCDPK5" AND ,
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PMC
PF3D7_1412400 OR PF14_0123, (4)
PMC
PF3D7_1145200 OR PF11_0464, (5)
PMC
nucleoporin Nup43 isoform X2 [Homo sapiens]
nucleoporin Nup43 isoform X2 [Homo sapiens]
gi|530383655|ref|XP_005267017.1|

Protein
CBST441.rev NICHD_XGC_tropThy1 Xenopus tropicalis cDNA clone IMAGE:8922713 3', m...
CBST441.rev NICHD_XGC_tropThy1 Xenopus tropicalis cDNA clone IMAGE:8922713 3', mRNA sequence
gi|126552168|gnl|dbEST|45066042|gb| 683.1|

Nucleotide

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