Illustrates model performance metrics with single- and two-tier feature selection, including feature selection using only XGBoost and Boruta, along with receiver operating characteristic curves (ROC), precision-recall curves (PRC) predicted by models with two-tier feature selection. These evaluations are conducted on both the training set (MIMIC-III) and the validation sets (MIMIC-IV, eICU-CRD), with the receiver operating characteristic curves presented alongside a shaded 95% confidence interval (ROC (95% CI)). (A–C) denote the ROC, PRC, and ROC (95% CI) predicted by the model using only XGBoost for feature selection, respectively. (A′–C′) denote the ROC, PRC, and ROC (95% CI) predicted by the model using only Boruta for feature selection. (E–G) denote the ROC, PRC, and ROC (95% CI) predicted by the model using two-tier feature selection on the training set. (E′–G′) denotes the AUROC, PRC, and ROC (95% CI) predicted by the model using two-tier feature selection on Validation 1 (MIMIC-IV). (E″–G″) denotes AUROC, PRC, and ROC (95% CI) predicted by the model using two-tier feature selection on Validation2 (eICU-CRD). CI confidence interval.