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Select item 85372521.

Dose- and Sex-Dependent Changes in Hemoglobin Oxygen Affinity by the Micronutrient 5-Hydroxymethylfurfural and α-Ketoglutaric Acid

Simon Woyke, Norbert Mair, Astrid Ortner, Thomas Haller, Marco Ronzani, Christopher Rugg, Mathias Ströhle, Reinhold Wintersteiger, Hannes Gatterer

Nutrients. 2021 Oct; 13(10): 3448. Published online 2021 Sep 29. doi: 10.3390/nu13103448

PMCID:: PMC8537252

Abstract Article PDF–1.6M

Select item 90654152.

Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Jenifer Masip, Norma Rallón, Elena Yeregui, Montserrat Olona, Salvador Resino, José M. Benito, Consuelo Viladés, Graciano García-Pardo, José Alcamí, Ezequiel Ruiz-Mateos, Frederic Gómez-Bertomeu, Montserrat Vargas, Marta Navarro, José A. Oteo, Juan A. Pineda, Anna Martí, Verónica Alba, Francesc Vidal, Joaquin Peraire, Anna Rull

Front Immunol. 2022; 13: 822272. Published online 2022 Apr 20. doi: 10.3389/fimmu.2022.822272

PMCID:: PMC9065415

Abstract Article PDF–2.7M

Select item 56829723.

The periplasmic transaminase PtaA of Pseudomonas fluorescens converts the glutamic acid residue at the pyoverdine fluorophore to α-ketoglutaric acid

Michael T. Ringel, Gerald Dräger, Thomas Brüser

J Biol Chem. 2017 Nov 10; 292(45): 18660–18671. Published online 2017 Sep 14. doi: 10.1074/jbc.M117.812545

PMCID:: PMC5682972

Abstract Article PDF–2.5M

Select item 90679314.

α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling

Yexian Yuan, Canjun Zhu, Yongliang Wang, Jia Sun, Jinlong Feng, Zewei Ma, Penglin Li, Wentong Peng, Cong Yin, Guli Xu, Pingwen Xu, Yuwei Jiang, Qingyan Jiang, Gang Shu

Sci Adv. 2022 May; 8(18): eabn2879. Published online 2022 May 4. doi: 10.1126/sciadv.abn2879

PMCID:: PMC9067931

Abstract Article PDF–4.7M

Select item 65270725.

Engineering of L-amino acid deaminases for the production of α-keto acids from L-amino acids

Project Nshimiyimana, Long Liu, Guocheng Du

Bioengineered. 2019; 10(1): 43–51. Published online 2019 Mar 27. doi: 10.1080/21655979.2019.1595990

PMCID:: PMC6527072

Abstract Article PDF–1010K

Select item 76129086.

Labile Photo‐Induced Free Radical in α‐Ketoglutaric Acid: a Universal Endogenous Polarizing Agent for In Vivo Hyperpolarized ¹³C Magnetic Resonance

Dr. Adam P. Gaunt, Dr. Jennifer S. Lewis, Friederike Hesse, Dr. Tian Cheng, Dr. Irene Marco‐Rius, Prof. Kevin M. Brindle, Dr. Arnaud Comment

Angew Chem Int Ed Engl. 2022 Jan 10; 61(2): e202112982. Published online 2021 Nov 25. doi: 10.1002/anie.202112982

PMCID:: PMC7612908

Abstract Article PDF–1009K

Select item 104340247.

Analysis of Regulatory Mechanism of AcrB and CpxR on Colistin Susceptibility Based on Transcriptome and Metabolome of Salmonella Typhimurium

Ya-Jun Zhai, Pei-Yi Liu, Xing-Wei Luo, Jun Liang, Ya-Wei Sun, Xiao-Die Cui, Dan-Dan He, Yu-Shan Pan, Hua Wu, Gong-Zheng Hu

Microbiol Spectr. 2023 Jul-Aug; 11(4): e00530-23. Published online 2023 Jun 26. doi: 10.1128/spectrum.00530-23

PMCID:: PMC10434024

Abstract Article PDF–4.1M

Select item 68033108.

Growth Dynamics and Survival of Liberibacter crescens BT-1, an Important Model Organism for the Citrus Huanglongbing Pathogen “Candidatus Liberibacter asiaticus”

Marta Sena-Vélez, Sean D. Holland, Manu Aggarwal, Nick G. Cogan, Mukesh Jain, Dean W. Gabriel, Kathryn M. Jones

Appl Environ Microbiol. 2019 Nov 1; 85(21): e01656-19. Prepublished online 2019 Aug 16. Published online 2019 Oct 16. doi: 10.1128/AEM.01656-19

PMCID:: PMC6803310

Abstract Article PDF–2.4M

Select item 110551159.

A Study on the Efficient Preparation of α-Ketoglutarate with L-Glutamate Oxidase

Shuhui Niu, Fang Liu, Yaping Wang, Ben Rao, Yueying Wang

Molecules. 2024 Apr; 29(8): 1861. Published online 2024 Apr 19. doi: 10.3390/molecules29081861

PMCID:: PMC11055115

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Select item 830459810.

Application of a New Engineered Strain of Yarrowia lipolytica for Effective Production of Calcium Ketoglutarate Dietary Supplements

Ludwika Tomaszewska-Hetman, Anita Rywińska, Zbigniew Lazar, Piotr Juszczyk, Magdalena Rakicka-Pustułka, Tomasz Janek, Marta Kuźmińska-Bajor, Waldemar Rymowicz

Int J Mol Sci. 2021 Jul; 22(14): 7577. Published online 2021 Jul 15. doi: 10.3390/ijms22147577

PMCID:: PMC8304598

Abstract Article PDF–1.0M

Select item 340614311.

Ketoglutarate Transport Protein KgtP Is Secreted through the Type III Secretion System and Contributes to Virulence in Xanthomonas oryzae pv. oryzae

Wei Guo, Lu-Lu Cai, Hua-Song Zou, Wen-Xiu Ma, Xi-Ling Liu, Li-Fang Zou, Yu-Rong Li, Xiao-Bin Chen, Gong-You Chen

Appl Environ Microbiol. 2012 Aug; 78(16): 5672–5681. doi: 10.1128/AEM.07997-11

PMCID:: PMC3406143

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Select item 834665012.

Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts

Margarita Gerou, Benjamin Hall, Ryan Woof, Jessica Allsop, Stephen J. Kolb, Kathrin Meyer, Pamela J. Shaw, Scott P. Allen

Neurobiol Aging. 2021 Sep; 105: 64–77. doi: 10.1016/j.neurobiolaging.2021.04.013

PMCID:: PMC8346650

Abstract Article

Select item 711014013.

Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation

Yexian Yuan, Pingwen Xu, Qingyan Jiang, Xingcai Cai, Tao Wang, Wentong Peng, Jiajie Sun, Canjun Zhu, Cha Zhang, Dong Yue, Zhihui He, Jinping Yang, Yuxian Zeng, Man Du, Fenglin Zhang, Lucas Ibrahimi, Sarah Schaul, Yuwei Jiang, Jiqiu Wang, Jia Sun, Qiaoping Wang, Liming Liu, Songbo Wang, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Cong Yin, Fan Li, Guli Xu, Yongliang Zhang, Gang Shu

EMBO J. 2020 Apr 1; 39(7): e103304. Published online 2020 Feb 27. doi: 10.15252/embj.2019103304

Correction in:: EMBO J. 2021 Jul 15; 40(14): e108434.

PMCID:: PMC7110140

Abstract Article PDF–4.3M

Select item 27795614.

BACTERIAL OXIDATION OF DIPICOLINIC ACID: II. Identification of α-Ketoglutaric Acid and 3-Hydroxydipicolinic Acid and Some Properties of Cell-free Extracts

Yasuo Kobayashi, Kei Arima

J Bacteriol. 1962 Oct; 84(4): 765–771. doi: 10.1128/jb.84.4.765-771.1962

PMCID:: PMC277956

Summary Page Browse PDF–930K

Select item 286386915.

Comparison of the Plating Efficiencies and Shelf Lives of Three Different Commercial Buffered Charcoal Yeast Extract Media Supplemented with α-Ketoglutaric Acid

Paul H. Edelstein, Martha A. C. Edelstein

J Clin Microbiol. 2010 May; 48(5): 1882–1883. Published online 2010 Mar 3. doi: 10.1128/JCM.01399-09

PMCID:: PMC2863869

Abstract Article PDF–116K

Select item 968652716.

Effects of In Ovo Injection of α-Ketoglutaric Acid on Hatchability, Growth, Plasma Metabolites, and Antioxidant Status of Broilers

Vaishali Gupta, Chris Major Ncho, Akshat Goel, Chae-Mi Jeong, Yang-Ho Choi

Antioxidants (Basel) 2022 Nov; 11(11): 2102. Published online 2022 Oct 25. doi: 10.3390/antiox11112102

PMCID:: PMC9686527

Abstract Article PDF–1.9M

Select item 836110617.

Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters

Seth J. Parker, Joel Encarnación-Rosado, Kate E. R. Hollinshead, David M. Hollinshead, Leonard J. Ash, Juan A. K. Rossi, Elaine Y. Lin, Albert S. W. Sohn, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman

Nat Commun. 2021; 12: 4905. Published online 2021 Aug 12. doi: 10.1038/s41467-021-25228-9

PMCID:: PMC8361106

Abstract Article PDF–1.1M

Select item 973353218.

Castration alters the cecal microbiota and inhibits growth in Holstein cattle

Zemin Li, Jinping Shi, Yu Lei, Jianping Wu, Rui Zhang, Xiao Zhang, Li Jia, Ying Wang, Yue Ma, Pengjia He, Yannan Ma, Qiang Cheng, Zhao Zhang, Ke Zhang, Zhaomin Lei

J Anim Sci. 2022 Dec; 100(12): skac367. Published online 2022 Nov 3. doi: 10.1093/jas/skac367

PMCID:: PMC9733532

Abstract Article PDF–2.4M

Select item 646636219.

α-Ketoglutaric Acid-Modified Carbonate Apatite Enhances Cellular Uptake and Cytotoxicity of a Raf-Kinase Inhibitor in Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways

Sultana Mehbuba Hossain, Jayalaxmi Shetty, Kyi Kyi Tha, Ezharul Hoque Chowdhury

Biomedicines. 2019 Mar; 7(1): 4. Published online 2019 Jan 3. doi: 10.3390/biomedicines7010004

PMCID:: PMC6466362

Abstract Article PDF–6.0M

Select item 996805720.

R97 at “Handlebar” Binding Mode in Active Pocket Plays an Important Role in Fe(II)/α-Ketoglutaric Acid-Dependent Dioxygenase cis-P3H-Mediated Selective Synthesis of (2S,3R)-3-Hydroxypipecolic Acid

Jiaojiao Guan, Yilei Lu, Zixuan Dai, Songyin Zhao, Yan Xu, Yao Nie

Molecules. 2023 Feb; 28(4): 1854. Published online 2023 Feb 15. doi: 10.3390/molecules28041854

PMCID:: PMC9968057

Abstract Article PDF–5.0M

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Figure 2

Optical Images of α-KAMCA particle formation. (A) only DMEM media without any NPs. (B) CA (carbonate apatite) NPs formulated with 4 mM exogenous calcium. (C) α-KAMCA NPs formulated with 4 mM exogenous calcium and 1 mM α-ketoglutaric acid. (D) α-KAMCA NPs formulated with 4 mM exogenous calcium and 2 mM α-ketoglutaric acid. (E) α-KAMCA NPs formulated with 4 mM exogenous calcium and 4 mM α-ketoglutaric acid. (F) α-KAMCA NPs formulated with 4 mM exogenous calcium and 8 mM α-ketoglutaric acid. (G) α-KAMCA NPs formulated with 4 mM exogenous calcium and 16 mM α-ketoglutaric acid.

α-Ketoglutaric Acid-Modified Carbonate Apatite Enhances Cellular Uptake and Cytotoxicity of a Raf-Kinase Inhibitor in Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways

Biomedicines. 2019 Mar;7(1):4.
Figure 4

Particle size distribution analysis of CA and α-KAMCA NPs by dynamic light scattering (DLS). (A) CA NPs prepared with 4 mM Ca²⁺. (B) α-KAMCA NPs prepared with 4 mM Ca²⁺ and 1 mM α-ketoglutaric acid. (C) α-KAMCA NPs prepared with 4 mM Ca²⁺ + and 2 mM α-ketoglutaric acid. (D) α-KAMCA NPs prepared with 4 mM Ca²⁺ and 4 mM α-ketoglutaric acid. (E) α-KAMCA NPs prepared with 4 mM Ca²⁺ and 8 mM α-ketoglutaric acid). (F) α-KAMCA NPs prepared with 4 mM Ca²⁺ and 16 mM α-ketoglutaric acid.

α-Ketoglutaric Acid-Modified Carbonate Apatite Enhances Cellular Uptake and Cytotoxicity of a Raf-Kinase Inhibitor in Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways

Biomedicines. 2019 Mar;7(1):4.
Figure 3

Dose-dependent changes in oxygen partial pressure at half saturation (P50) of (a) 5-hydroxy-methylfurfural (5-HMF) with α-ketoglutaric acid (αKG) (5-HMF + αKG), (b) 5-hydroxy-methylfurfural alone (5-HMF) and (c) α-ketoglutaric acid alone (αKG). Grey lines indicate individual courses for females and black lines for males, and black circles show the mean ± SD of all subjects. The colored lines represent the linear regression function with the parameters shown for females (red) and males (blue), respectively.

Dose- and Sex-Dependent Changes in Hemoglobin Oxygen Affinity by the Micronutrient 5-Hydroxymethylfurfural and α-Ketoglutaric Acid

Nutrients. 2021 Oct;13(10):3448.
Figure 4

Comparison of oxygen dissociation curves (ODCs) of 5-hydroxymethylfurfural (5-HMF; orange) alone and 5-hydroxymethylfurfural (5-HMF) with α-ketoglutaric acid (5-HMF + αKG; green) as indicated by the interaction of mean oxygen partial pressure at half saturation (P50) and mean Hill coefficient (HC) of all subjects.

Dose- and Sex-Dependent Changes in Hemoglobin Oxygen Affinity by the Micronutrient 5-Hydroxymethylfurfural and α-Ketoglutaric Acid

Nutrients. 2021 Oct;13(10):3448.