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Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate at 0.25 to 1 uM incubated for 10 mins by fluorimetric analysis
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 9 Tested
Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate at 100 uM preincubated for 10 mins followed by substrate addition by fluorimetric analysis relative to control
Assay data:9 Tested
Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate at 100 uM by fluorimetric analysis relative to control
Assay data:11 Tested
Inhibition of Trypanosoma cruzi Tulahuen 2 Cruzain using Z-Phe-Arg-AMC as flurogenic substrate at 100 uM by spectrophotometry based analysis relative to control
Assay data:1 Tested
Inhibition of Trypanosoma cruzi Cruzain
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of Trypanosoma cruzi Cruzain using Z-Phe-Arg-AMC as flurogenic substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Trypanosoma cruzi Cruzain assessed as Kcat/Km
Assay data:5 Tested
Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constant
Assay data:14 Active, 12 Activity ≤ 1 µM, 14 Tested
Assay data:14 Active, 5 Activity ≤ 1 µM, 23 Tested
Inhibition of recombinant Trypanosoma cruzi Cruzipain (104 to 212 residues) expressed in baculovirus expression system using Z-Phe-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition by spectrofluorometry analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:25 Active, 19 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Inhibition of recombinant Trypanosoma cruzi Tulahuen 2 cruzain incubated for 5 mins folllowed by Z-Phe-Arg-AMC substrate by fluorometric assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of epimastigote form of Trypanosoma cruzi Tulahuen 2 cruzain assessed as reduction in 7-amino-4-methylcoumarin release incubated for 20 mins folllowed by Z-FR-AMC substrate addition and measured up to 45 mins by fluorometric assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 11 Tested
Inhibition of Cruzaine derived from epimastigotes of Trypanosoma cruzi Tul2 strain using Z-FR-AMC as substrate assessed as release of 7-amino-4-methylcoumarin by fluorimetry
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Trypanosoma cruzi Cruzaine
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of Trypanosoma cruzi Cruzaine using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured for 10 mins by spectrophotometry
Reversible inhibition of Trypanosoma cruzi cruzain using Cbz-Phe-Arg-AMC as substrate assessed as enzyme recovery preincubated for 2 hrs followed by 100-fold dilution in presence of substrate by rapid dilution assay
Assay data:3 Tested
Binding affinity to Trypanosoma cruzi cruzain assessed as covalent bond formation between compound and Cys25 residue by 2D HSQC NMR spectroscopy analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to Trypanosoma cruzi cruzain assessed as formation of enzyme-inhibitor adducts by measuring mass changes by mass spectrometric analysis
Assay data:4 Active, 4 Tested
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