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Inhibition of TRPC6 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of OAG-evoked Ca2+ entry by measuring reduction in intracellular Ca2+ level by Fluo-4 dye based FLIPR assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human TRPC6 expressed in HEK293F cells assessed as inhibition of carbachol-induced calcium response up to 20 uM
Electrophysiology Assay from US Patent US11274091: "Cyclopentane compounds"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
High Throughput Screening Assay from US Patent US10889568: "Inhibitors of TRPC6"
Assay data:95 Active, 87 Activity ≤ 1 µM, 95 Tested
High Throughput Screening Assay from US Patent US10800757: "Inhibitors of TRPC6"
Assay data:94 Active, 86 Activity ≤ 1 µM, 94 Tested
TRP selectivity screen (TRPC6)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human TRPC6 at <= 30 uM
Inhibition of human TRPC6 channel transfected in HEK293 cells assessed as intracellular calcium level by FLIPR assay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of OAG-activated human TRPC6 channel expressed in HEK293 cells by Q-patch clamp assay
Antagonist activity at TRPC3/TRPC6 (unknown origin)
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx preincubated for 2 mins followed by OAG stimulation by fluo-4/AM dye based FLIPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human TRPC6 expressed in thapsigargin pretreated HEK293 cells assessed as reduction in GPCR-induced calcium entry by fluo-4/AM dye based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of YFP-tagged human TRPC6 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye based fluorescence assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assay
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
Inhibition of TRPC6 (unknown origin)
Human TRPC6 (Transient Receptor Potential channels)
Assay data:16 Active, 16 Tested
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