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RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to human GKRP assessed as inhibition of protein interaction with human glucokinase by measuring ATP depletion after 60 mins by luciferase-based luminescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaScreen assay
Assay data:22 Active, 16 Activity ≤ 1 µM, 24 Tested
Binding affinity to human GKRP by surface plasmon resonance analysis
Assay data:11 Active, 10 Activity ≤ 1 µM, 14 Tested
Inhibition of human biotin-labeled GKRP and fluorescein-labeled human GK interaction preincubated for 20 mins prior to fluorescein-labeled human GK addition measured after 2 to 4 hrs by AlphaScreen assay
Assay data:37 Active, 32 Activity ≤ 1 µM, 40 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Inhibition of biotin-tagged human GKRP/fluorescein-tagged GK interaction preincubated for 20 mins prior to GK addition measured after 2 to 4 hrs by AlphaScreen assay
Assay data:39 Active, 34 Activity ≤ 1 µM, 40 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addition measured after 2 to 4 hrs by AlphaScreen assay
Assay data:24 Active, 11 Activity ≤ 1 µM, 24 Tested
Binding affinity to GKRP (unknown origin) by surface plasmon resonance analysis
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay
Assay data:4 Active, 1279 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: ADP-Glo assay
Assay data:3 Active, 1277 Tested
qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: Diaphorase-coupled assay
Assay data:3 Active, 11 Activity ≤ 1 µM, 1279 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
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