BioAssay by Target (List) for Gene (Select 11091) - PubChem BioAssay - NCBI

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Select item 19292831.

Inhibition of human WDR5 WIN site expressed in Escherichia coli

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1929283

Summary Related BioAssays by Target

Select item 19197322.

Enzyme assay of inhibition against MLL1-WDR5 protein-protein interactions from US Patent US20230286948: "HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR"

Source:: BindingDB

Protein Targets:: Histone-lysine N-methyltransferase 2A; ...
Total:: 2

Assay data:21 Active, 10 Activity ≤ 1 µM, 56 Tested

AID:: 1919732

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19197283.

Enzyme Assay of Inhibition Against MLL1-WDR5 Protein-Protein Interactions from US Patent US20230286925: "PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR"

Source:: BindingDB

Protein Targets:: Histone-lysine N-methyltransferase 2A; ...
Total:: 2

Assay data:33 Active, 32 Activity ≤ 1 µM, 33 Tested

AID:: 1919728

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19153114.

Selectivity interaction (Reader proteins panel (DSF assay)) EUB0000034d WDR5

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Tested

AID:: 1915311

Summary Related BioAssays by Target

Select item 19143495.

Selectivity interaction (Methyl-Lysine/Arginine panel (DSF assay)) EUB0000211b WDR5

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Tested

AID:: 1914349

Summary Related BioAssays by Target

Select item 19143486.

Selectivity interaction (ITC) EUB0000211b WDR5

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914348

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19132287.

Affinity Biochemical interaction (Biacore) EUB0000211b WDR5

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913228

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127798.

Affinity Phenotypic Cellular interaction (Western Blot (effect on WDR5-MLL interaction in HEK293 cells)) EUB0000211b WDR5

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912779

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19086319.

Competitive binding affinity to N-terminal 6xHis-SUMO-tagged human WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold (DE3) cells assessed as inhibition constant using 10-mer-Thr-FAM peptide as substrate incubated for 1 hr by Lantha Screen based TR-FRET assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:36 Active, 34 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 39 Tested

AID:: 1908631

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190862210.

Inhibition of N-terminal 6xHis-SUMO-tagged human WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold (DE3) cells assessed as inhibition constant incubated for 1 hr by TR-FRET assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1908622

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190862011.

Inhibition of MLL1-WDR5 (unknown origin) interaction using 10mer-Thr-FAM as substrate by fluorescence polarization based competitive binding assay

Source:: ChEMBL

Protein Targets:: Histone-lysine N-methyltransferase 2A; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1908620

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190861812.

Binding affinity to WDR5 (unknown origin) using 10mer-Thr-FAM as substrate incubated for 30 mins by fluorescence polarization based competitive binding assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1908618

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190861713.

Binding affinity to poly histidine tagged-human WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3)-V2R-pRARE2 assessed as dissociation constant by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1908617

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190861514.

Inhibition of 5- FAM labeled tracer binding to N-terminal His6-SUMO-tagged WDR5 (24 to 334 residues) (unknown origin) expressed in Escherichia coli Rosetta 2 (DE3) cells incubated for 3 hrs by fluorescence polarization based competitive binding assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1908615

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189560115.

Binding affinity to WDR5 (unknown origin) WIN site using 10mer-Thr-FAM probe incubated for 2 hrs by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1895601

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189558916.

Binding affinity to WDR5 (unknown origin) by isothermal titration calorimetry

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1895589

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189558817.

Binding affinity to human WDR5 by isothermal titration calorimetry

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Tested

AID:: 1895588

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 189558718.

Displacement of GSARAEVHLRKS from human WDR5 by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Tested

AID:: 1895587

Summary PubMed Citation Related BioAssays by Target

Select item 189558119.

Binding affinity to WDR5 (unknown origin) fluorescence polarization assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:8 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1895581

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189557920.

Binding affinity to N-terminal His-tagged and C-terminal Avi-tagged full length human WDR5 WIN site expressed in Escherichia coli measured upto 600 sec by Surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: WD repeat-containing protein 5

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1895579

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (114)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (21)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (68)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (84)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (183)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (175)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (20)
BioAssays deposited by other experimentalists

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