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TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
enzyme-inhibition screening assay from US Patent US11059842: "Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases"
Assay data:12 Active, 8 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Kinetic Assay from Article 10.3109/14756366.2012.668539: "Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assembly Assay from US Patent US9422231: "Method for inhibiting Trypanosoma cruzi"
Assay data:3 Active, 5 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
CYP51 Inhibition Assay from Article 10.1074/jbc.M113.497990: "Complexes of Trypanosoma cruzi sterol 14a-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from Article 10.1074/jbc.M109.045336: "Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Enzymatic Assay from Article 10.1111/j.1747-0285.2012.01416.x: "Novel Cruzain Inhibitors for the Treatment of Chagas' Disease."
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition Assay from Article 10.1016/j.chembiol.2007.10.011: "Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth."
Assay data:17 Active, 16 Activity ≤ 1 µM, 17 Tested
Spectral Titration of TCCYP51 from Article 10.1021/jm801643b: "Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase."
Assay data:13 Active, 10 Activity ≤ 1 µM, 13 Tested
TryR Enzyme Inhibition Assay from Article 10.1021/jm801306g: "Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors."
Assay data:19 Tested
Inhibition of N-terminal His6-tagged Trypanosoma cruzi HGXPRT isoform B expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of IMP formation using hypoxanthine as substrate by spectrophotometric assay
Assay data:13 Tested
SummaryPubMed Citation
Inhibition of N-terminal His6-tagged Trypanosoma cruzi HGPRT isoform C expressed in Escherichia coli C43(DE3) cells assessed as inhibition of IMP formation using hypoxanthine as substrate by spectrophotometric assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 13 Tested
Antiparasitic activity against Trypanosoma cruzi DM28c epimastigotes harboring TcMCA3 assessed reduction in parasite viability incubated for 72 hrs by MTT assay
Assay data:1 Tested
Antitrypanosomal activity against bloodstream Trypanosoma cruzi Y strain trypomastigote assessed as reduction in parasite viability incubated for 24 hrs by Neubauer chamber based analysis
Antitrypanosomal activity against Trypanosoma cruzi Dm28c epimastigotes assessed as reduction in parasite viability incubated for 48 hrs by trypan blue staining based Neubauer counting chamber analysis
Inhibition of recombinant Trypanosoma cruzi Cruzipain (104 to 212 residues) expressed in baculovirus expression system using Z-Phe-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition by spectrofluorometry analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Trypanosoma cruzi Sterol 14-alpha demethylase
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antitrypanosomal activity against amastigotes form of Trypanosoma cruzi CA-I/72 infected in mouse C2C12 cells assessed as parasite infection level by DAPI staining based microscopic analysis
Assay data:20 Active, 23 Activity ≤ 1 µM, 24 Tested
Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysis
Assay data:25 Active, 19 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Antiparasitic activity against Trypanosoma cruzi amastigotes infected in vero cells assessed as parasite growth inhibition incubated for 48 hrs by light microscopy
Assay data:5 Tested
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