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In Silico Screening from Article 10.1002/cbic.201700052: "Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
OctetRed from Article : "LPXC in CSAR_FULL_RELEASE_3JULY2012"
Assay data:13 Active, 3 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ITC from Article : "LPXC in CSAR_FULL_RELEASE_3JULY2012"
Assay data:9 Active, 4 Activity ≤ 1 µM, 10 Tested
Thermofluor from Article : "LPXC in CSAR_FULL_RELEASE_3JULY2012"
Assay data:13 Active, 8 Activity ≤ 1 µM, 32 Tested
Fluorescent Coupled Assay from Article 10.1016/j.chembiol.2007.12.013: "Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites."
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Fluorescent Competition Assay from Article 10.1016/j.chembiol.2007.12.013: "Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites."
Assay data:8 Active, 8 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Ligand Affinity Measurements from Article 10.1016/j.bmc.2007.01.044: "Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC."
Assay data:9 Active, 1 Activity ≤ 1 µM, 12 Tested
Binding affinity to Aquifex aeolicus LpxC assessed as inhibition constant at pH 5.5
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of MraY in Aquifex aeolicus
Assay data:19 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Sulfurihydrogenibium yellowstonense alpha carbonic anhydrase incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of Aquifex aeolicus MraY expressed in Escherichia coli C41(DE3) using Park's nucleotide as substrate pretreated for 30 mins followed by substrate addition measured up to 2 mins by fluorescence assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant Sulfurihydrogenibium azorense alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant Sulfurihydrogenibium yellostonense alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
Assay data:40 Active, 40 Activity ≤ 1 µM, 40 Tested
Inhibition of Aquifex aeolicus IspH
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21(DE3)
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21(DE3) using HMBPP as substrate preincubated for 10 mins followed by substrate addition
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrate
Assay data:4 Active, 1 Activity ≤ 1 µM, 21 Tested
Inhibition of Sulfurihydrogenibium azorense alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
Assay data:19 Active, 2 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
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