Homo sapiens hyperpolarization activated cyclic nucleotide gated potas - Nucleotide

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A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family. [Proc Natl Acad Sci U S A. 2023]
A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family.
Cámara-Checa A, Perin F, Rubio-Alarcón M, Dago M, Crespo-García T, Rapún J, Marín M, Cebrián J, Gómez R, Bermúdez-Jiménez F, et al. Proc Natl Acad Sci U S A. 2023 Dec 5; 120(49):e2305135120. Epub 2023 Nov 30.
Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation. [J Biol Chem. 2022]
Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation.
Wang H, Wu T, Huang Z, Huang J, Geng Z, Cui B, Yan Y, Zhang Y, Wang Y. J Biol Chem. 2022 Nov; 298(11):102599. Epub 2022 Oct 14.
Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system. [Cell Mol Life Sci. 2022]
Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system.
Peischard S, Möller M, Disse P, Ho HT, Verkerk AO, Strutz-Seebohm N, Budde T, Meuth SG, Schweizer PA, Morris S, et al. Cell Mol Life Sci. 2022 Jul 21; 79(8):440. Epub 2022 Jul 21.

RefSeq alternative splicing
See 3 reference mRNA sequence splice variants for the HCN4 gene.
RefSeq protein product
See the reference protein sequence for potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (NP_005468.1).

Protein
Protein sequence from Nucleotide coding region
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GenScript latest version of gene cDNA ORF Clone [GenScript latest version of g...]
GenScript latest version of gene cDNA ORF Clone
HCN4 [Guide to Pharmacology]
HCN4
Guide to Pharmacology
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Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium chann...
Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA
gi|1519312820|ref|NM_005477.3|

Nucleotide

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Nucleotide