MeSH

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.

Year introduced: 2002(1963)

A major gonadotropin secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and the LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. The alpha subunit is common in the three human pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.

Year introduced: 2004

The beta subunit of follicle stimulating hormone. It is a 15-kDa glycopolypeptide. Full biological activity of FSH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the FSHB gene causes delayed puberty, or infertility.

Year introduced: 2003

Cell surface proteins that bind FOLLICLE STIMULATING HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells.

Year introduced: 1987

Date introduced: August 25, 2010

nucleotide sequence given in first source

Date introduced: May 24, 1988

A protein extract of human menopausal urine in which LUTEINIZING HORMONE has been partially or completely removed. Urofollitropin represents FOLLICLE STIMULATING HORMONE from the urine.

Year introduced: 2006

The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.

Year introduced: 1989

a synthetic peptide encompassing the sequence of human FSH beta subunit, amino acids (51-65); induces uptake of calcium by liposomes

Date introduced: June 28, 1991

a synthetic peptide encompassing the sequence of human FSH beta subunit, amino acids (81-95); amino acid sequence given in first source

Date introduced: April 30, 1990

Receptors with a 6-kDa protein on the surfaces of cells that secrete LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE, usually in the adenohypophysis. LUTEINIZING HORMONE-RELEASING HORMONE binds to these receptors, is endocytosed with the receptor and, in the cell, triggers the release of LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE by the cell. These receptors are also found in rat gonads. INHIBINS prevent the binding of GnRH to its receptors.

Year introduced: 1994

Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.

Year introduced: 1967(1965)

contains Ser, Gly, Arg, Thr, Ala, Pro, Val, Lys, hexoses, & ethanolamine

Date introduced: August 6, 2004

a long-acting recombinant FSH like substance, consisting of the human FSH alpha-subunit and a hybrid beta-subunit that is composed of the human FSH beta-subunit and the C-terminus part (CTP) of the human HCG beta-subunit

Date introduced: October 18, 2001

induces uptake of calcium by liposomes

Date introduced: June 28, 1991

contains Ser, Gly, Arg, Thr, Ala, Pro, Val, Lys, hexoses, & ethanolamine

Date introduced: March 25, 1990

Date introduced: April 29, 2007

Date introduced: April 29, 2007

LRPR1 - Leucine-Rich Primary Response gene 1; from rat Sertoli cells; 746 amino acids, MW 85.6 kDa; RefSeq NM_012955

Date introduced: June 26, 1995

a synthetic peptide encompassing the discontinuous segments of the human FSH beta subunit, amino acids (33-53) and (81-95); has higher affinity for FSH receptor than either synthetic hFSH-beta-(33-53) or hFSH-beta-(81-95)

Date introduced: March 2, 1992