Histamine H1 Antagonists, Non-Sedating
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Year introduced: 2003
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Subheadings:
Tree Number(s): D27.505.519.625.375.425.400.500, D27.505.696.577.375.425.400.500
MeSH Unique ID: D039563
Entry Terms:
- Histamine H1 Antagonists, Non Sedating
- Second Generation H1 Antagonist
- H1 Antihistamines, Non-Sedating
- H1 Antihistamines, Non Sedating
- Non-Sedating H1 Antihistamines
- Second Generation Antihistamines
- Antihistamines, Second Generation
- Second Generation H1 Antagonists
- Second Generation Antihistamine
- Antihistamine, Second Generation
- Generation Antihistamine, Second
- Third Generation H1 Antagonists
- Third Generation H1 Antagonist
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