Platelet Glycoprotein GPIIb-IIIa Complex
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Year introduced: 1996(1987)
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Subheadings:
Tree Number(s): D09.400.430.890.625.785, D12.776.395.550.625.785, D12.776.543.550.625.785, D12.776.543.750.705.408.460.700, D12.776.543.750.705.675.784
MeSH Unique ID: D019039
Entry Terms:
- Platelet Glycoprotein GPIIb IIIa Complex
- Integrin alpha-IIb beta-3
- beta-3, Integrin alpha-IIb
- Integrin alpha IIb beta 3
- Glycoproteins IIb-IIIa
- Glycoproteins IIb IIIa
- Integrin alphaIIbbeta3
- alphaIIbbeta3, Integrin
- GPIIb-IIIa Receptors
- GPIIb IIIa Receptors
- Receptors, GPIIb-IIIa
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