Dactinomycin

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Year introduced: 1966

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Tree Number(s): D03.633.300.200, D04.345.566.252, D12.644.641.252

MeSH Unique ID: D003609

Registry Number: 1CC1JFE158

Entry Terms:

• Actinomycin D
• Meractinomycin
• Actinomycin
• Cosmegen
• Lyovac-Cosmegen
• LyovacCosmegen
• Lyovac Cosmegen
• Cosmegen Lyovac
• Lyovac, Cosmegen

Pharmacologic Action:

• Anti-Bacterial Agents
• Antibiotics, Antineoplastic
• Protein Synthesis Inhibitors
• Nucleic Acid Synthesis Inhibitors

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Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 3-Ring
Dactinomycin

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Chemicals and Drugs Category
Polycyclic Compounds
Macrocyclic Compounds
Peptides, Cyclic
Dactinomycin

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Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Peptides, Cyclic
Dactinomycin